A5007706730- Neural dynamics and brain function
- Neuroscience and Music Perception
- Multisensory perception and integration
- EEG and Brain-Computer Interfaces
- Visual perception and processing mechanisms
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Animal Vocal Communication and Behavior
- Face Recognition and Perception
- Hearing Loss and Rehabilitation
- Anesthesia and Neurotoxicity Research
- Neurobiology and Insect Physiology Research
- Noise Effects and Management
- Photoreceptor and optogenetics research
- Cephalopods and Marine Biology
- Craniofacial Disorders and Treatments
- Anatomy and Medical Technology
- Action Observation and Synchronization
Yale University
2021-2025
University of New Haven
2021-2023
University of Pennsylvania
2011-2018
University of Arizona
2008
University of Virginia
2008
The full neural circuits of conscious perception remain unknown. Using a visual task, we directly recorded subcortical thalamic awareness potential (TAP). We also developed unique paradigm to classify perceived versus not stimuli using eye measurements remove confounding signals related reporting on experiences. fMRI, discovered three major brain networks driving independent report: first, increases in signal detection regions visual, fusiform cortex, and frontal fields; arousal/salience...
Although recent work has made headway in understanding the neural temporospatial dynamics of conscious perception, much that focused on visual paradigms. To determine whether there are shared mechanisms for perceptual consciousness across sensory modalities, here we test within auditory domain. Participants completed an threshold task while undergoing intracranial electroencephalography. Recordings from >2,800 grey matter electrodes were analyzed broadband gamma power (a range which reflects...
A fundamental problem in hearing is detecting a "target" stimulus (e.g., friend's voice) that presented with noisy background the din of crowded restaurant). Despite its importance to hearing, relationship between spiking activity and behavioral performance during such "detection-in-noise" task has yet be fully elucidated. In this study, we recorded primary auditory cortex (A1) while rhesus monkeys detected target was noise background. Although some neurons were modulated, response typical...
During visual conscious perception, the earliest responses linked to signal detection are little known. The current study aims reveal cortical neural activity changes in stages of perception using recordings from intracranial electrodes. Epilepsy patients (N=158) were recruited a multi-center collaboration and completed word recall task. Broadband gamma (40-115Hz) was extracted with band-pass filter power calculated across subjects on common brain surface. Our results show early increases...
The specific contribution of core auditory cortex to perception –such as categorization– remains controversial. To identify a the primary (A1) perception, we recorded A1 activity while monkeys reported whether temporal sequence tone bursts was heard having "small" or "large" frequency difference. We found that had frequency-tuned responses habituated, independent content, this unfolded over time. also firing rate modulated by monkeys' reports and differences; modulation correlated with their...
Startle reflexes employ specialized neuronal circuits and synaptic features for rapid transmission of information from sense organs to responding muscles. Successful excitation these pathways requires the coincidence sensory input at central contacts with giant fiber targets. Here we describe a pathway feature in crayfish tailflip reflex: A position-dependent linear gradation axonal conduction velocities that can ensure coincident arrival impulses near-field hydrodynamic sensilla along...
Adaptive behavior depends on an animal's ability to ignore uninformative stimuli, such as repeated presentations of the same stimulus, and, instead, detect informative, novel stimuli in its environment. The primate prefrontal cortex (PFC) is known play a central role this ability. However, neural mechanisms underlying differentiate between and are not clear. We hypothesized that coupling different frequency bands local field potential (LFP) underlies PFC's differentiating stimuli....
The earliest cortical neural signals following consciously perceived visual stimuli in humans are poorly understood. Using intracranial electroencephalography, we investigated activity changes associated with the stages of stimulus detection during conscious perception. Participants (N = 10; 1,693 electrode contacts) completed a continuous performance task where subjects were asked to press button when they saw target letter among series nontargets. Broadband gamma power (40-115 Hz) was...
Abstract Consciousness is not explained by a single mechanism, rather it involves multiple specialized neural systems overlapping in space and time. We hypothesize that synergistic, large-scale subcortical cortical attention signal processing networks encode conscious experiences. To identify brain activity perception without overt report, we classified visual stimuli as perceived or using eye measurements. Report-independent event-related potentials functional magnetic resonance imaging...
Conscious perception of visual stimuli involves large-scale brain networks with multiple activation-deactivation dynamics. Previous works have shown that early detection may be switched off about 200ms to 300ms after presentation a stimulus. We hypothesize these deactivations represent selective control mechanism the conserve resources for post-perceptual processing. To this end, we used attentional blink as behavioral measure mechanism. showed is more likely occur when previous stimulus was...
Abstract The origins of awareness action (AoA), the ability to report an just performed, remain elusive. Differing theories ascribe AoA pre-action, efferent motor/volitional mechanisms versus post-action, afferent sensory/perceptual neural mechanisms. To study these two types and others, we developed a paradigm where very similar aware unaware actions occur repeatedly. Aware demonstrated larger neurophysiological signals both preceding following movement. differences included well-known...
Abstract Understanding the neural basis of consciousness is a fundamental goal neuroscience. Many studies tackling this question have focused on conscious perception, but these been largely vision-centric, with very few involving tactile perception. Therefore, we developed novel threshold perception task, which used in conjunction high-density scalp electroencephalography and eye-metric recordings. Participants were delivered threshold-level vibrations to one four non-thumb fingers, asked...
Abstract Although recent work has made significant headway in understanding the temporal and spatial dynamics of neural mechanisms conscious perception, much that focused on visual paradigms. To determine whether there are shared for perceptual consciousness across sensory modalities, here we developed a task to test within auditory domain. Participants (n=31) completed an threshold while undergoing intracranial electroencephalography (icEEG) intractable epilepsy. Intracranial recordings...
Abstract The neural mechanisms of visual conscious perception have been investigated for decades. However, the spatiotemporal dynamics associated with earliest responses following consciously perceived stimuli are still poorly understood. Using a dataset intracranial EEG recordings, current study aims to investigate activity changes stages perception. Subjects (N=10, 1,693 grey matter electrode contacts) completed continuous performance task in which individual letters were presented series...
Abstract Understanding consciousness is one of the most important and challenging questions in modern science. Existing theories have pursued single unifying mechanisms but do not succeed explaining consciousness. Importantly, neural circuits that distinguish messages arrive from outside world attain remained unknown. Here we identify signals throughout entire brain at high spatiotemporal resolution specifically related to To accomplish this, combined a large sample size electrical...