A5081595760- Dementia and Cognitive Impairment Research
- Pain Mechanisms and Treatments
- Pain Management and Placebo Effect
- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Systemic Lupus Erythematosus Research
- Alzheimer's disease research and treatments
- Dysphagia Assessment and Management
- Airway Management and Intubation Techniques
- Peripheral Neuropathies and Disorders
- Neurological disorders and treatments
- Contact Dermatitis and Allergies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Musculoskeletal pain and rehabilitation
- Ginkgo biloba and Cashew Applications
- Mental Health Research Topics
- Obsessive-Compulsive Spectrum Disorders
- Tracheal and airway disorders
- Botulinum Toxin and Related Neurological Disorders
- Ocular Diseases and Behçet’s Syndrome
- Skin and Cellular Biology Research
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Hormonal and reproductive studies
Hanyang University
2007-2024
Boramae Medical Center
2019
Objective: The aim was to investigate the white matter abnormalities of drug‐naïve patients with obsessive–compulsive disorder (OCD) using diffusion tensor‐imaging and changes in after pharmacotherapy. Method: Thirteen OCD 13 age‐ sex‐matched healthy comparison subjects were examined structural magnetic resonance imaging. Measurements made before 12 weeks citalopram treatment. Results: Compared controls, showed significant increases fractional anisotropy (FA) corpus callosum, internal...
Background and purpose We investigated changes in deep gray matter ( DGM ) volume its relationship to cognition clinical factors a large cohort of patients with neuromyelitis optica spectrum disorder NMOSD compared them results from multiple sclerosis MS ). Methods Brain magnetic resonance imaging (3 Tesla) data 91 , 52 44 healthy controls HCs were prospectively evaluated. Differences volumes among groups. The relationships between atrophy variables also analysed. Results Patients exhibited...
Background and purpose To evaluate whether white matter hyperintensities ( WMH s) may act as an independent predictor for progression of cognitive status, the authors analyzed longitudinal effects WMHs on dysfunction in non‐demented patients with Parkinson's disease (PD). Methods A total 111 PD were enrolled, including subjects mild impairment MCI , n = 65) cognitively normal CN 46). These individuals classified converters 22) or non‐converters 43) 18) 28) based they subsequently diagnosed...
Background and purpose The occult changes in normal‐appearing white matter ( NAWM ) were investigated compared amongst patients with neuromyelitis optica spectrum disorder NMOSD ), multiple sclerosis MS healthy controls HC s) by applying tract‐based spatial statistics to diffusion tensor imaging DTI data. Methods Diffusion was performed a 3‐T scanner 93 , 53 43 s. Voxel‐wise statistical analyses of the data using statistics. Results Compared s, had significantly lower mean global fractional...
Background and purpose Recent studies have demonstrated that Alzheimer's disease ( AD ) subcortical vascular dementia SV aD) white matter WM microstructural changes. However, previous on aD rarely eliminated the confounding effects of patients with mixed cerebrovascular pathologies. Therefore, our aim was to evaluate divergent topography changes in pure aD. Methods Patients who were clinically diagnosed prospectively recruited. Forty Pittsburgh compound B (PiB) positive [PiB(+) ] without...
Although the exact mechanism of TENS pain relief is unknown, it believed that impulses interrupt nociceptive signals at dorsal horn spinal cord.To evaluate hypotheses during caused by noxious stimuli, brain responses, temporal summation and functional connectivity are modulated TENS, mechanisms differ between men women.During fMRI scanning, same stimuli were delivered to each participant in pain-only pain+TENS conditions. In condition, presented without TENS. participants received...
To clarify whether subtyping of amnestic and non-amnestic mild cognitive impairment (MCI) is clinically relevant in Parkinson's disease (PD) by analyzing patterns neuroimaging longitudinal changes.We performed comparative analyses cortical thickness, hippocampal volume, white matter integrity resting-state functional connectivity between the patients with de-novo PD MCI (PD-aMCI) (n = 50) (PD-naMCI) subtypes. Additionally, we assessed rate decline each domain over time dementia conversion...
Background This study investigated whether pain and pain‐related unpleasantness ratings were altered by blood testosterone levels. We also activation of brain regions that represent intensity [primary somatosensory cortex (S1)] [perigenual ACC (pACC) orbitofrontal (OFC)] affected Methods Twenty‐six healthy men recruited. Blood levels measured before fMRI scanning. The participants classified into two groups (high vs. low testosterone) according to their level (each group n = 13). middle...
Background and purpose Studies on cortical involvement its relationship with cognitive function in patients neuromyelitis optica spectrum disorder (NMOSD) remain scarce. The objective of this study was to compare thickness magnetic resonance imaging (MRI) between NMOSD multiple sclerosis (MS) investigate clinical features function. Methods This observational 91 NMOSD, 52 MS 44 healthy controls conducted from 1 December 2013 30 April 2015 at the institutional referral center. Three tesla MRI...
Background and purpose Smoking is a major risk factor for cognitive decline dementia. However, the exact pathobiology of smoking remains unknown. The effects on cortical thickness as biomarker neurodegeneration or white matter hyperintensities lacunes biomarkers cerebrovascular burden were concurrently evaluated. Methods Our study included 977 cognitively normal men who visited health promotion centre underwent medical check‐ups, including 3.0 T magnetic resonance imaging. Participants...
Summary The aim of this study was to evaluate the effectiveness cricoid and paralaryngeal force for oesophageal entrance occlusion during induction anaesthesia. Seventy‐four patients were included in randomised, crossover study. relative position glottis outer anteroposterior diameter upper assessed at baseline, after application 30 N force, rate with direct laryngoscopy. changed 45 out 74 anaesthesia laryngoscopy compared awake state. decreased mean ( SD ) a similar degree (8.5 (2.1) mm 6.4...
Background We hypothesize that pain and brain responses are affected by changes in the presentation sequence of noxious stimuli are, overall, identical intensity duration. Methods During functional magnetic resonance imaging ( fMRI ) scanning, 21 participants experienced three patterns stimulation: Up‐type (step‐up stimulation, 15 s), Down‐type (step‐down Down–up‐type (decreasing increasing pattern s). The total duration stimulation were identical, but sequences different. Results Pain...
Synopsis A new abrasion tool (US patent US7087063 B2) has been developed for collecting skin epidermal samples. This device includes a central shaft that holds the probe in split chuck. Of variety of designs tested, laser‐cut hollow tube (HT) abraded basal layer epidermis most consistently, resulting representative Compared with traditional clinical methods, method allows high‐throughput collection minimal invasiveness to volunteer subjects. large number samples have collected various...
Stress is a complex factor that simultaneously triggers both psychological and physiological changes in humans. However, research on the relationship between aspects of stress has been limited. This study assessed factors related to using questionnaires evaluated reactivity recovery based examined characteristics. We administered including Perceived Scale (PSS) Connor-Davidson Resilience (CD-RISC) group 56 police officers. also performed stress-inducing experiments, which consisted Trier...