A5051185462- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Autism Spectrum Disorder Research
- Nuclear Receptors and Signaling
- Olfactory and Sensory Function Studies
- Genetic Neurodegenerative Diseases
- Market Dynamics and Volatility
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Ginkgo biloba and Cashew Applications
- Neurological and metabolic disorders
- Neurobiology of Language and Bilingualism
- Monetary Policy and Economic Impact
- Spinal Dysraphism and Malformations
- Lysosomal Storage Disorders Research
- Neurotransmitter Receptor Influence on Behavior
Yonsei University
2015-2025
Gangnam Severance Hospital
2022-2025
Inje University
2024
Wonju Severance Christian Hospital
2024
Severance Hospital
1997-2023
Catholic Kwandong University
2023
International St. Mary's Hospital
2023
Yonsei University Health System
2020-2021
Alzheimer Precision Medicine
2021
Sorbonne Université
2021
PURPOSE: To evaluate the effectiveness of three-phase spiral computed tomography (CT) for evaluation nodular hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Images obtained at CT in 45 patients with 81 HCCs were reviewed. 10-mm collimation and 10 mm/sec table speed during intravenous administration 2 mL/kg 68% nonionic contrast material a rate 3 mL/sec. Hepatic arterial-phase (AP), portal-phase (PP), delayed-phase (DP) images 25-30 seconds, 60-70 300 respectively, after injection...
Abstract This study aimed to investigate the cortical neural correlates of dementia conversion in Parkinson's disease with mild cognitive impairment (PD‐MCI). We classified 112 patients drug‐naïve early stage PD meeting criteria for PD‐MCI into either (PDD) converters ( n = 34) or nonconverters 78), depending on whether they developed within 4 years diagnosis. Cortical thickness analyses were performed 34 PDD and matched nonconverters. Additionally, a linear discriminant analysis was...
Parkinson's disease is a progressive neurodegenerative disorder characterized by the intracellular accumulation of insoluble alpha-synuclein aggregates into Lewy bodies and neurites. Increasing evidence indicates that progression results from spread pathologic through neuronal networks. However, exact mechanisms underlying propagation abnormal proteins in brain are only partially understood. The objective this study was first to describe long-term spatiotemporal distributions Lewy-related...
<h3>Objective</h3> To investigate the association between enlarged perivascular spaces (PVS) in basal ganglia (BG-PVS) and long-term motor outcomes Parkinson disease (PD). <h3>Methods</h3> We reviewed medical records of 248 patients with drug-naive early-stage PD (follow-up >3 years, mean age 67.44 ± 8.46 130 female) who underwent brain MRI dopamine transporter (DAT) scans at initial assessment. The number baseline BG-PVS was counted on axial T2-weighted images. Then, were divided into 2...
Abstract Dipeptidyl peptidase 4 (DPP4) inhibitors are widely used hypoglycaemic agents and improve glucose metabolism by enhancing the bioavailability of active glucagon-like peptide-1. In this study, we hypothesized that treatment with DPP4 may have beneficial effects on nigrostriatal dopamine longitudinal motor performance in diabetic patients Parkinson’s disease. We classified 697 drug naive de novo disease who had undergone transporter imaging into three groups according to a prior...
We evaluated the patterns of quantitative electroencephalography (EEG) in patients with Alzheimer's disease (AD), Lewy body (LBD), and mixed disease. Sixteen AD, 38 LBD, 20 disease, 17 control participants were recruited underwent EEG. The theta/alpha ratio theta/beta measured. relationship log-transformed (TAR) (TBR) group, presence AD clinical symptoms evaluated. Participants LBD groups had higher TBR all lobes except for occipital lobe than those group. was independently associated...
PURPOSE: To compare hepatic angiographic findings of small arterial-portal venous shunts with those other imaging modalities, and to determine whether these are related hepatocellular carcinoma. MATERIALS AND METHODS: At angiography in 223 patients, not directly carcinoma focal areas parenchymal contrast material enhancement more than 1 cm diameter were found 28 patients. These patients prospectively evaluated computed tomography (CT) during arterial portography (CTAP) (n = 12), CT after...
Olfactory dysfunction is common in Alzheimer's disease- and Lewy body-related disorders, but its neural correlates have not been clearly elucidated.We retrospectively recruited 237 patients with disease-related cognitive impairment (ADCI) 217 (LBCI). They were identically evaluated using the Cross-Cultural Smell Identification Test, neuropsychological tests, brain magnetic resonance imaging.LBCI had more severe olfactory than ADCI. Patients worse function both groups. In ADCI, lower Test...
Mutations in lysosomal genes increase the risk of neurodegenerative diseases, as is case for Parkinson's disease. Here, we found that pathogenic and protective mutations arylsulfatase A (ARSA), a gene responsible metachromatic leukodystrophy, storage disorder, are linked to Plasma ARSA protein levels were changed disease patients. deficiency caused increases α-synuclein aggregation secretion, propagation cells nematodes. Despite being protein, directly interacts with cytosol. The interaction...
Abstract This study aimed to investigate the potential beneficial effects of estrogen on nigrostriatal dopaminergic neuron degeneration in postmenopausal drug-naïve Parkinson’s disease (PD). Based ratio lifetime exposure length total and deprivation period, women with PD were divided into low (n = 31) high groups. We performed a comparative analysis striatal dopamine transporter (DAT) availability between two Additionally, we evaluated longitudinal change levodopa equivalent dose per month...
The endoplasmic reticulum (ER) is selectively degraded by ER-phagy to maintain cell homeostasis. α-synuclein accumulates in the ER, causing ER stress that contributes neurodegeneration Parkinson’s disease (PD), but role of modulation largely unknown. Here, we investigated mechanisms which recognizes for degradation ER. We found played an important and recovery function through interaction with FAM134B, where calnexin required selective FAM134B-mediated clearance via ER-phagy. Overexpression...
Abstract Patients with dementia Lewy bodies (DLB) show widespread brain metabolic changes. This study investigated whether hypo- and hypermetabolism in DLB have differential effects on cognition. We enrolled 55 patients (15 prodromal [MCI-LB] 40 probable DLB) 13 healthy controls who underwent 18 F-fluorodeoxyglucose positron emission tomography detailed neuropsychological tests. Metabolic indices reflecting associated changes regional cerebral glucose metabolism were calculated as follows:...
Parkinson disease (PD) is a multisystem disorder marked by progressive dopaminergic neuronal degeneration in the substantia nigra, as well nondopaminergic systems. Our aim was to investigate longitudinal changes <i>N</i>-(3-[<sup>18</sup>F]fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (<sup>18</sup>F-FP-CIT) binding at putamen, and raphe nuclei PD. <b>Methods:</b> This retrospective cohort study enrolled 127 patients with PD, who underwent <sup>18</sup>F-FP-CIT PET scans twice or...
To elucidate the role of basal forebrain (BF) in non-motor symptoms Parkinson's disease (PD), we investigated association sleep quality and cognition with BF volume functional connectivity. The gray matter anterior intermediate part (Ch4ai) lateral (Ch4al) nucleus basalis Meynert were negatively associated PSQI global score. posterior (Ch4p) was positively visuospatial, memory, executive functions. score correlated connectivity from Ch4al to cingulate, inferior parietal, temporal, medial...
The purpose of this study was to document the usefulness early triphasic image acquisition during gadolinium-enhanced multiphase dynamic MR imaging for detection contrast enhancement in small hepatocellular carcinoma.Dynamic performed 332 patients at 1.5 T using a T1-weighted fast low-angle shot sequence (TR range/TE, 113-130/4.1; flip angle, 80 degrees). With start bolus injection gadolinium dimeglumine (0.1 mmol/kg) into antecubital vein, three sets contrast-enhanced images entire liver...
Most clinical trials focus on amyloid-β positive (Aβ+) amnestic mild cognitive impairment (aMCI), but screening failures are high because only a half of patients with aMCI Aβ PET. Therefore, it becomes necessary for clinicians to predict which will have biomarker.We aimed compare factors, neuropsychological (NP) profiles, and apolipoprotein E (APOE) genotype between Aβ+ Aβ-aMCI develop clinically useful prediction model positivity PET (PET-Aβ+) in using nomogram.We recruited 523 who...
To investigate whether the patterns of striatal dopamine depletion on transporter (DAT) scans could provide information long-term prognosis in Parkinson disease (PD).We enrolled 205 drug-naive patients with early-stage PD, who underwent 18F-FP-CIT PET at initial assessment and received PD medications for 3 or more years. After quantifying DAT availability each subregion, factor analysis was conducted to simplify identification yield 4 subregion factors. We assessed effect these factors...