A5078595355- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Mental Health Research Topics
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Bipolar Disorder and Treatment
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
- Single-cell and spatial transcriptomics
- solar cell performance optimization
- Ion channel regulation and function
- Ion Transport and Channel Regulation
- Semiconductor Quantum Structures and Devices
- Biomedical Text Mining and Ontologies
- Molecular Biology Techniques and Applications
- Atomic and Subatomic Physics Research
- Nanowire Synthesis and Applications
- Alcoholism and Thiamine Deficiency
- Electricity Theft Detection Techniques
- Tryptophan and brain disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mentoring and Academic Development
Montreal Neurological Institute and Hospital
2020-2025
McGill University
2020-2025
Shanghai Sixth People's Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
University of Virginia
2008-2025
University of Science and Technology of China
2024
Changchun Institute of Applied Chemistry
2024
Chinese Academy of Sciences
2024
University of Toronto
2023-2024
Hospital for Sick Children
2023-2024
Abstract Imaging technologies are increasingly used to generate high-resolution reference maps of brain structure and function. Comparing experimentally generated these facilitates cross-disciplinary scientific discovery. Although recent data sharing initiatives increase the accessibility maps, often shared in disparate coordinate systems, precluding systematic accurate comparisons. Here we introduce neuromaps, a toolbox for accessing, transforming analyzing structural functional...
Abstract Functional interactions between brain regions can be viewed as a network, enabling neuroscientists to investigate function through network science. Here, we systematically evaluate 768 data-processing pipelines for reconstruction from resting-state functional MRI, evaluating the effect of parcellation, connectivity definition, and global signal regression. Our criteria seek that minimise motion confounds spurious test-retest discrepancies topology, while being sensitive both...
The wiring of the brain is organized around a putative unimodal-transmodal hierarchy. Here we investigate how this intrinsic hierarchical organization shapes transmission information among regions. positioning individual regions was quantified by applying diffusion map embedding to resting-state functional MRI networks. Structural networks were reconstructed from spectrum imaging and topological shortest paths all computed. Sequences nodes encountered along path then labeled their position,...
The relationship between structural and functional connectivity in the brain is a key question systems neuroscience. Modern accounts assume single global structure-function that persists over time. Here we study coupling from dynamic perspective, show it regionally heterogeneous. We use temporal unwrapping procedure to identify moment-to-moment co-fluctuations neural activity, reconstruct time-resolved patterns. find patterns of are region-specific. observe stable unimodal transmodal cortex,...
Imaging technologies are increasingly used to generate high-resolution reference maps of brain structure and function. Modern scientific discovery relies on making comparisons between new (e.g. task activations, group structural differences) these maps. Although recent data sharing initiatives have increased the accessibility such maps, often shared in disparate coordinate systems (or “spaces”), precluding systematic accurate among them. Here we introduce neuromaps toolbox, an open-access...
Glutamate is traditionally viewed as the first messenger to activate NMDAR (N-methyl-D-aspartate receptor)-dependent cell death pathways in stroke
Parkinson's disease is a progressive neurodegenerative disorder characterized by the intracellular accumulation of insoluble alpha-synuclein aggregates into Lewy bodies and neurites. Increasing evidence indicates that progression results from spread pathologic through neuronal networks. However, exact mechanisms underlying propagation abnormal proteins in brain are only partially understood. The objective this study was first to describe long-term spatiotemporal distributions Lewy-related...
Stroke prognosis is negatively associated with an elevation of serum bilirubin, but how bilirubin worsens outcomes remains mysterious. We report that post-, not pre-, stroke levels among inpatients scale infarct volume. In mouse models, increases neuronal excitability and ischemic infarct, whereas insults induce the release endogenous all which are attenuated by knockout TRPM2 channel or its antagonist A23. Independent canonical intracellular agonists, metabolic derivatives gate opening, A23...
The relationship between structural and functional connectivity in the brain is a key question connectomics. Here we quantify patterns of structure-function coupling across neocortex, by comparing estimated using diffusion MRI with both neurophysiological (MEG-based) haemodynamic (fMRI-based) recordings. We find that heterogeneous regions frequency bands. link generally stronger multiple MEG bands compared to resting state fMRI. Structure-function greater slower intermediate faster also...
The networked architecture of the brain promotes synchrony among neuronal populations and emergence coherent dynamics. These communication patterns can be comprehensively mapped using noninvasive functional imaging, resulting in connectivity (FC) networks. Despite its popularity, FC is a statistical construct operational definition arbitrary. While most studies use zero-lag Pearson's correlations by default, there exist hundreds pairwise interaction statistics broader scientific literature...
Blood perfusion delivers oxygen and nutrients to all cells, making it a fundamental feature of brain organization. How cerebral blood maps onto micro-, meso- macro-scale structure function is therefore key question in neuroscience. Here we analyze pseudo-continuous arterial spin labeling (ASL) data from 1,305 healthy individuals the HCP Lifespan studies (5-100 years) reconstruct high-resolution normative map. At cellular molecular level, co-localizes with granular layer IV, biological...
Objective Controversy remains as to which obesity measures better predict type 2 diabetes (T2D) risk in overweight or obese individuals. The objective of this study is determine commonly used reflect beta cell function and T2D participants with validate the findings using prospective cohort data.
The spatial patterning of gene expression shapes cortical organization and function. macaque is a fundamental model organism in neuroscience, but the translational potential rests on assumption that it good proxy for patterns corresponding proteins (vertical translation) orthologous human genes (horizontal translation). Here, we systematically benchmark regional cortex against (i) receptor density vivo ex microstructure (ii) expression. We find moderate cortex-wide correspondence between...
Bilirubin, an endogenous metabolite with many significant physiological roles, particularly anti-inflammatory properties, shows great promise as a treatment for inflammatory diseases. However, the binding targets and downstream signaling mechanisms of bilirubin remain unclear. Here, by using quantitative phosphorylation proteomics several powerful chemical biology techniques such Cellular Thermal Shift Assay (CETSA), molecular docking, MicroScale Thermophoresis (MST), it is identified...
The intrinsic dynamics of neuronal circuits shape information processing and cognitive function. Combining non-invasive neuroimaging with anaesthetic-induced suppression provides a unique opportunity to understand how local mediate the link between neurobiology organism's functional repertoire. To address this question, we compile dataset multi-scale neural activity during wakefulness anesthesia encompassing human, macaque, marmoset, mouse nematode. We then apply massive feature extraction...
Objectives: The function of the Hypothalamic–Pituitary–Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA measures between subjects methadone stabilization and drug-free detoxification with healthy controls. Methods: Sixty heroin dependent patients received either non-opiate treatment (NOT) benzodiazepines clonidine (n = 30) or (MT, n 30), their serum levels corticotropin releasing hormone (CRH), adrenocorticotropic (ACTH), cortisol (COR) were measured to...
The brain is a complex network of interconnected and interacting neuronal populations. Global efforts to understand the emergence behavior effect perturbations depend on accurate reconstruction white matter pathways, both in humans model organisms. An emerging animal for next-generation applied neuroscience common marmoset ( Callithrix jacchus). A recent open respository retrograde anterograde tract tracing presents an opportunity systematically study architecture (Marmoset Brain...
Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here we report that bilirubin (BIL)-dependent cell death auditory brainstem of neonatal mice both sexes significantly attenuated by ZD7288, blocker hyperpolarization-activated cyclic nucleotide-gated (HCN) channel mediated current (I
We addressed the link between excessive exposure to insulin and mitochondrion-derived oxidative stress in this study found that prolonged increased mitochondrial cholesterol cultured hepatocytes mice stimulated production of reactive oxygen species (ROS) decreased reduced glutathione disulfide ratio hepatocytes. Exposure isolated hepatic mitochondria alone promoted ROS emission. The induced by was prevented inhibition synthesis with simvastatin. further membrane potential came from...
Abstract The brain’s structural connectivity supports the propagation of electrical impulses, manifesting as patterns coactivation, termed functional connectivity. Functional emerges from underlying sparse connections, particularly through polysynaptic communication. As a result, connections between brain regions without direct links are numerous, but their organization is not completely understood. Here we investigate links. We develop simple, data-driven method to benchmark with respect...
The wiring of the brain is organized around a putative unimodal-transmodal hierarchy. Here we investigate how this intrinsic hierarchical organization shapes transmission information among regions. positioning individual regions was quantified by applying diffusion map embedding to resting state functional MRI networks. Structural networks were reconstructed from spectrum imaging and topological shortest paths all computed. Sequences nodes encountered along path labelled their position,...
Abstract Functional interactions between brain regions can be viewed as a network, empowering neuroscientists to leverage network science investigate distributed function. However, obtaining from functional neuroimaging data involves multiple steps of manipulation, which drastically affect the organisation and validity estimated its properties. Here, we provide systematic evaluation 576 unique data-processing pipelines for connectomics resting-state MRI, obtained all possible recombinations...
ABSTRACT A significant challenge in bipolar disorder (BD) is to understand the neural substrates of emotional fluctuations (i.e., episode phases) along spectrum including manic (BipM), depressive (BipD), and remission states (rBD). Here, We constructed intrinsic functional connectome for 117 subjects with BD (BipM: 38, BipD: 42, rBD: 37) 35 healthy controls, then associated connectivities identify common specific patterns, finally probed their biological underpinnings. uncovered altered...