A5101522866- Hearing, Cochlea, Tinnitus, Genetics
- Neonatal Health and Biochemistry
- Cancer-related molecular mechanisms research
- Hearing Loss and Rehabilitation
- Heat shock proteins research
- Neuroscience of respiration and sleep
- Erythrocyte Function and Pathophysiology
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Radiopharmaceutical Chemistry and Applications
- Microtubule and mitosis dynamics
- Hearing Impairment and Communication
- Neuroscience and Neural Engineering
- Ferroptosis and cancer prognosis
- Occupational Health and Performance
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Barrier Structure and Function Studies
- Biochemical and Molecular Research
- Extracellular vesicles in disease
- Heme Oxygenase-1 and Carbon Monoxide
- Immune Response and Inflammation
- Receptor Mechanisms and Signaling
- Conducting polymers and applications
- Cancer, Lipids, and Metabolism
Moderna Therapeutics (United States)
2022-2024
Shanghai Sixth People's Hospital
2017-2023
XinHua Hospital
2020-2023
Shanghai Jiao Tong University
2015-2023
Renji Hospital
2023
Tianjin University
2022
CSPC Pharmaceutical Group
2022
APLA Health
2022
First Affiliated Hospital of Xinjiang Medical University
2022
Xinjiang Medical University
2022
Stroke prognosis is negatively associated with an elevation of serum bilirubin, but how bilirubin worsens outcomes remains mysterious. We report that post-, not pre-, stroke levels among inpatients scale infarct volume. In mouse models, increases neuronal excitability and ischemic infarct, whereas insults induce the release endogenous all which are attenuated by knockout TRPM2 channel or its antagonist A23. Independent canonical intracellular agonists, metabolic derivatives gate opening, A23...
Propionic acidemia (PA) is an ultrarare disorder caused by deficiency of the mitochondrial enzyme, propionyl-CoA carboxylase (PCC), composed PCCA and PCCB subunits. An enzyme replacement therapy being developed using dual messenger RNA (mRNA) lipid nanoparticles (LNPs) encapsulating mRNAs encoding subunits PCC enzyme. We herein report on development a translational semimechanistic pharmacokinetic (PK) PK/pharmacodynamic (PD) model to quantify relationship between mRNA components mRNA-3927...
Abstract Heart failure (HF) is a complex, progressive disorder that associated with substantial morbidity and mortality on global scale. Relaxin‐2 naturally occurring hormone may have potential therapeutic benefit for patients HF. To investigate the of relaxin in treatment HF, mRNA‐0184, novel, investigational, lipid nanoparticle (LNP)–encapsulated mRNA therapy encodes human relaxin‐2 fused to variable light chain kappa (Rel2‐vlk) was developed. A translational semi‐mechanistic population...
Abstract Neonatal brain is particularly vulnerable to pathological levels of bilirubin which elevates and overloads intracellular Ca 2+ , leading neurotoxicity. However, how voltage-gated calcium channels (VGCCs) are functionally involved in excess influx remains unknown. By performing voltage-clamp recordings from bushy cells the ventral cochlear nucleus (VCN) postnatal rat pups (P4-17), we found total current density was more than doubled over P4-17, but relative weight VGCC subtypes...
Abstract The biomedical application of corannulene π ‐bowls is historically limited by low solubility and bioavailability despite the potential in their unique electronic properties for new functional materials. Herein, unexpected role molecular mechanism Corranulene are uncovered applications as an effective anticancer agent Warburg effect mediated selective tumor targeting. triazolyl monosaccharides Cor‐sugars exhibit highly potent cytotoxicity against human cancer cells effectively...
Nicotinamide adenine dinucleotide (NAD+) is an important molecule with extensive biological functions in various cellular processes, including protection against cell injuries. However, little known regarding the roles of NAD+ neuronal excitation and excitotoxicity associated many neurodegenerative disorders diseases. Using patch-clamp recordings, we studied its potential effects on principal neurons ventral cochlear nucleus (VCN), which particularly vulnerable to bilirubin excitotoxicity....
The present study aimed to investigate the effect of Buyang Huanwu decoction (BYHWD) on tumor growth, metastasis and angiogenesis in nude mice bearing human hepatocellular carcinoma (HCC) HCCLM3 xenografts. A total 96 xenografts were randomly divided into four groups: BYHWD group (LB), Yi‑qi (LY), Huo‑xue (LH) model (LM). Each these groups was three subgroups (n=8), which observed days 21, 25, 38 following treatment, respectively. weights, volumes pulmonary metastases recorded. expression...
In developing sensory systems, elaborate morphological connectivity between peripheral cells and first-order central neurons emerges via genetic programming before the onset of activities. However, how acquire capacity to interface with remains elusive. By making patch-clamp recordings from mouse brainstem slices, we found that a subset in cochlear nuclei, first station receive acoustic impulses, exhibits spontaneous firings (SFs) as early at birth, fraction such increases during prehearing...
Abstract Neonatal jaundice is prevalent among newborns and can lead to severe neurological deficits, particularly sensorimotor dysfunction. Previous studies have shown that bilirubin (BIL) enhances the intrinsic excitability of central neurons this potentially contribute their overexcitation, Ca 2+ overload, neurotoxicity. However, cellular mechanisms underlying elevated neuronal remain unknown. By performing patch-clamp recordings from neonatal in rat medial vestibular nucleus (MVN), a...
Objective: To investigate the hearing protection outcomes of different drug-eluting analog electrode arrays implanted into guinea pig cochleae. Methods: Sixty pigs were randomly divided a negative control group and five experimental groups separately with blank (drug carrier), dexamethasone (DXM), aracytine (Ara-C), Ara-C+DXM, nicotinamide adenine dinucleotide (NAD+) eluting arrays. Micro CT was used to supervise surgical procedure. Auditory brainstem response (ABR) thresholds measured...
To investigate the clinical characteristics and prognosis of nasopharyngeal carcinoma (NPC) in children adolescents different age groups.The data 51 patients with NPC aged ≤ 18 years who were treated Xinhua Hospital Affiliated to Shanghai Jiao Tong University School Medicine from January 2012 May 2017 retrospectively analyzed. The divided into group (≤12 old) adolescent (12-18 12 old as boundary. characteristics, diagnosis, treatment, groups compared.The symptoms first diagnosis mainly nasal...
Hepatocellular carcinoma (HCC) is the third most common cancer worldwide, and invasion metastasis are leading causes of death. Astragaloside IV (AS-IV), a kind traditional Chinese medicine, has been widely used in therapy. Cell Counting Kit-8, tube formation, Transwell analyses were performed to determine cell proliferation, invasion, angiogenesis human umbilical vein endothelial cells (HUVECs) under treatment Hep3B or SK-Hep1 cells-derived exosomes with without AS-IV treatment. Then, Rab27a...
PURPOSE: To evaluate the role of heat shock protein 27 (HSP27) in effect aerobic exercise on cardiac diastolic dysfunction type 2 diabetic rats. METHODS: Forty male Sprague-Dawley rats were randomly divided into four groups: control (C), (A), diabetes (D), and plus (DA). Type was induced by feeding with a high-fat high-sugar diet for 7 weeks followed single intraperitoneal injection streptozotocin (30mg/kg) Aerobic performed rodent treadmill at 21m/min 60 min, 5 days per week 8 weeks....
Background: We aimed to investigate the demographic situation relating people with hearing loss in Xinjiang, largest province China. The may vary between regions and races. Methods: conducted a population-based study. analyzed data obtained from 3931 impairments (i.e., Han or Uyghur ethnic groups) including children adults. accounted for survey design sampling size order ensure that estimates were regionally representative. Basic characteristics determined, an distribution analysis was based...
Abstract Background: Claudin 18 is a member of the claudin family tight junction tetraspan cell surface proteins. The 18.2 isoform (CLDN18.2) expressed in healthy gastric mucosa cells and largely absent from other normal adult types. In contrast to low expression tissues, CLDN18.2 highly overexpressed many cancer types including pancreatic malignancies at high frequencies (50-80%). tumor-normal differential make it an attractive target for both therapeutic monoclonal antibodies (mAbs)...