A5006129354- GDF15 and Related Biomarkers
- Nutrition and Health in Aging
- Biomarkers in Disease Mechanisms
- Connective Tissue Growth Factor Research
- RNA modifications and cancer
- Graphene and Nanomaterials Applications
- Heat shock proteins research
- Macrophage Migration Inhibitory Factor
- Cardiac Fibrosis and Remodeling
- Heavy Metal Exposure and Toxicity
- Genetics, Aging, and Longevity in Model Organisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Nanoparticles: synthesis and applications
- Galectins and Cancer Biology
- Inflammation biomarkers and pathways
- Cardiovascular Effects of Exercise
- Endoplasmic Reticulum Stress and Disease
- S100 Proteins and Annexins
Minzu University of China
2024
Chengdu Sport University
2020-2023
Hong Kong University of Science and Technology
2022
University of Hong Kong
2022
Pathologic cardiac remodeling and dysfunction are the most common complications of type 2 diabetes. Physical exercise is important in inhibiting myocardial pathologic restoring function The mitochondrial-derived peptide MOTS-c has exercise-like effects by improving insulin resistance, combatting hyperglycemia, reducing lipid accumulation. We investigated transcriptomic profiling aerobic on properties a rat model diabetes which was induced feeding high fat sugar diet combined with an...
Cardiac structure remodeling and dysfunction are common complications of diabetes, often leading to serious cardiovascular events. MOTS-c, a mitochondria-derived peptide, regulates metabolic homeostasis by accelerating glucose uptake improving insulin sensitivity. Plasma levels MOTS-c decreased in patients with diabetes. can improve vascular endothelial function, making it novel therapeutic target for the We investigated effects on cardiac function analyzed transcriptomic characteristics...
Abstract Cardiac remodeling is a physiological adaptation to aerobic exercise and which characterized by increases in ventricular volume the number of cardiomyocytes. The mitochondrial derived peptide MOTS-c functions as an important regulator physical capacity performance. Exercise elevates levels endogenous circulation myocardium, while can significantly enhance capacity. However, effects combined with on cardiac structure function are unclear. We used pressure–volume conductance catheter...
Myocardial remodeling and dysfunction are commonly observed in type 2 diabetes mellitus (T2DM). Aerobic exercise can partly alleviate diabetes-induced myocardial through its antioxidant actions. MOTS-c is a potential mimic. This study aimed to investigate the effects of on improving diabetic heart function mechanism identify whether improved defenses due aerobic exercise. Herein, we established rat model T2DM induced by high-fat diet combined with low-dose streptozotocin injection....
Physical exercise plays an important role in the management and prevention of diabetes. The mitochondrial-derived peptide MOTS-c can improve insulin resistance, decrease elevated blood glucose, reduce lipid accumulation. However, it is unknown if alone or combined with treatment affects cardiac function PURPOSE: To determine exercise-like effects on structure METHODS: Forty male Sprague-Dawley (SD) rats were randomly divided into four groups: control (C), diabetes (D), plus intervention (DE)...
PURPOSE: To explore the effects and molecular mechanisms of MOTS-c on diabetic myocardial damage. METHODS: Thirty male Sprague-Dawley (SD) rats were randomly divided into three groups: control (C), diabetes (D), plus MOTS-C intervention (DM). Type 2 was induced by a high-sugar high-fat diet combined with low-dosage streptozotocin (30 mg/kg, i.p.) injection. All in DM group injected (0.5 mg/kg/day for 8 weeks. Pathological changes tissues observed using hematoxylin-eosin (HE) staining...
PURPOSE: To evaluate the role of heat shock protein 27 (HSP27) in effect aerobic exercise on cardiac diastolic dysfunction type 2 diabetic rats. METHODS: Forty male Sprague-Dawley rats were randomly divided into four groups: control (C), (A), diabetes (D), and plus (DA). Type was induced by feeding with a high-fat high-sugar diet for 7 weeks followed single intraperitoneal injection streptozotocin (30mg/kg) Aerobic performed rodent treadmill at 21m/min 60 min, 5 days per week 8 weeks....
The heart is a highly adaptable organ that responds to changes in functional requirements due exposure internal and external stimuli. Physical exercise has unique stimulatory effects on the myocardium both healthy individuals those with health disorders, where are primarily determined by intensity recovery time of exercise. We investigated time-dependent different intensities myocardial transcriptional expression rats. Moderate induced more differentially expressed genes than high exercise,...
Mitochondrial dysfunction is considered as a major contributor to cardiac systolic and diastolic in diabetes. As newly identified mitochondria derived peptide, MOTS-c plays vital role the regulation of metabolic homeostasis was shown be closely related type 2 diabetes (T2D). We hypothesized that could prevent myocardial mitochondrial damage improve structure function T2D. PURPOSE: To explored effects molecular mechanisms on METHODS: Thirty male Sprague Dawley rats were randomly divided into...
The mitochondrial-derived peptide MOTS-c is an important cyto-protector in helping maintain mitochondrial function and cellular viability, regulating metabolic homeostasis. It to understand the effects of different exercise modalities on levels various physiological systems order identify its role as a signal physical exercise. PURPOSE: To explore comparative moderate-intensity aerobic resistance serum, skeletal muscle heart. METHODS: Thirty male Sprague-Dawley (SD) rats were randomly...