A5100409227- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Nerve injury and regeneration
- RNA modifications and cancer
- Marine Bivalve and Aquaculture Studies
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Neonatal Health and Biochemistry
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Fibroblast Growth Factor Research
- Microbial Metabolites in Food Biotechnology
- Inflammasome and immune disorders
- Cancer-related gene regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Glaucoma and retinal disorders
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Endometriosis Research and Treatment
- Flavonoids in Medical Research
Dalian Medical University
2005-2025
First Affiliated Hospital of Dalian Medical University
2005-2025
Kunming Medical University
2020-2025
Shanghai Sixth People's Hospital
2011-2025
Shanghai Jiao Tong University
2017-2025
Peking University
2021-2025
Beijing Jishuitan Hospital
2021-2025
Capital Medical University
2025
Second Hospital of Hebei Medical University
2013-2024
Hofstra University
2023-2024
Improving the quality of hospital antibiotic use is a major goal WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification could facilitate simple stewardship interventions that are widely applicable globally. We aimed present data on patterns paediatric AWaRe be used for local national interventions.1-day point prevalence survey prescription were combined from two independent networks: Global Antimicrobial...
Ubiquitin-proteasome pathway (UPS) and autophagy-lysosome (ALP) are the two major protein degradation pathways, which critical for proteostasis. Growing evidence indicates that proteasome inhibition-induced ALP activation is an adaptive response. Transcription Factor EB (TFEB) a master regulator of ALP. However, characteristics TFEB its role in not fully investigated. Here we reported half-life around 13.5 h neuronal-like cells, degraded through both non-neuronal cells. Moreover, impairment...
Abstract Cancer-associated fibroblasts (CAFs) contribute to tumour epithelial-mesenchymal transition (EMT) via interaction with cancer cells. However, the molecular mechanisms underlying tumour-promoting EMT of CAFs in lung adenocarcinoma (ADC) remain unclear. Here, we observed that isolated from ADC promoted production stromal cell-derived factor-1 (SDF-1) conditioned medium (CM). CAF-derived SDF-1 enhanced invasiveness and by upregulating CXCR4, β-catenin, PPARδ, while downregulating these...
Objective: Oridonin (Ori) is a diterpene compound that has multiple biological properties. Here, our study was conducted to observe the therapeutic effect of Ori on depression as well uncover mechanism. Methods: Lipopolysaccharide (LPS)-induced models were established both in C57BL/6 mice and primary astrocytes, which treated with Ori, autophagy agonist Rapamycin (Rap) inhibitor 3-Methyladenine (3-MA). The depressive-like behaviors assessed behavioral tests. Autophagy evaluated hippocampus...
Haploinsufficiency of the protein kinase Tbk1 has shown to cause both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, pathogenic mechanisms are unclear. Here we show that conditional neuronal deletion in leads cognitive locomotor deficits mice. Tbk1-NKO mice exhibited numerous neuropathological changes, including neurofibrillary tangles, abnormal dendrites, reduced dendritic spine density, cortical synapse loss. The Purkinje cell layer cerebellum presented...
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is an important mediator of neuroinflammatory responses that regulates inflammatory injury following cerebral ischemia and may be a potential target. Salidroside (Sal) has good anti-inflammatory effects; however, it remains unclear whether Sal can regulate NLRP3 activation through the Toll-like 4 (TLR4)/nuclear factor kappa B (NF-κB) signaling pathway after to alleviate injury.We established oxygen-glucose...
Epigallocatechin-3-gallate (EGCG) is a major component of green tea polyphenols which displays potential properties anticancer and neuroprotection. Here we show that protection motor neuron by EGCG associated with regulating glutamate level in organotypic culture rat spinal cord. In this model, blocked excitotoxicity caused threohydroxyaspartate, an inhibitor transporter. This property may be not due to its intrinsic antioxidative activity, because another antioxidant could regulate under...
Mild TBI is often accompanied by visual system dysfunction and injury, which at least partly caused microglial neuroinflammatory processes initiated the injury. Using our focal cranial blast mouse model of closed-skull mild TBI, we evaluated ability cannabinoid type-2 (CB2) receptor inverse agonist SMM-189, biases microglia from harmful M1 state to beneficial M2 state, mitigate injury after TBI. Male C57BL/6 or Thy1-EYFP reporter mice received a closed-head either 0-psi (sham) 50-psi left...
Abstract Aberrant microglial activation and neuroinflammation is a pathological hallmark of amyotrophic lateral sclerosis (ALS). Fractalkine (CX3CL1) mostly expressed on neuronal cells. The fractalkine receptor (CX3CR1) predominantly microglia. Many progressive neuroinflammatory disorders show disruption the CX3CL1/CX3CR1 communication system. But exact role in ALS pathology remains unknown. F1 nontransgenic/CX3CR1 +/− females were bred with SOD1 G93A /CX3CR1 males to produce F2 −/− , +/+ ....
Stem cells have been confirmed to be involved in the occurrence and development of diabetic retinopathy; however, underlying mechanisms remain unclear. In this study, we used Citespace software visually analyze 552 articles exploring stem cell-based treatment retinopathy over past 20 years, which were included Web Science Core Collection. We found following: (1) a co-citation analysis references cited by all indicated 15 clusters. cluster #0, representing cell field, some highly landmark...