A5102849835- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Peptidase Inhibition and Analysis
- Macrophage Migration Inhibitory Factor
- Cardiac Structural Anomalies and Repair
- Epigenetics and DNA Methylation
- Hair Growth and Disorders
- Inflammation biomarkers and pathways
- RNA Research and Splicing
- Autoimmune and Inflammatory Disorders Research
- CRISPR and Genetic Engineering
- Neonatal Respiratory Health Research
- NF-κB Signaling Pathways
- Erythrocyte Function and Pathophysiology
- Fibroblast Growth Factor Research
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
Second Hospital of Hebei Medical University
2019-2024
Hebei Medical University
2019-2024
Haploinsufficiency of the protein kinase Tbk1 has shown to cause both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, pathogenic mechanisms are unclear. Here we show that conditional neuronal deletion in leads cognitive locomotor deficits mice. Tbk1-NKO mice exhibited numerous neuropathological changes, including neurofibrillary tangles, abnormal dendrites, reduced dendritic spine density, cortical synapse loss. The Purkinje cell layer cerebellum presented...
Neutrophils, underestimated in multiple sclerosis (MS), are gaining increased attention for their significant functions patients with MS and the experimental autoimmune encephalomyelitis (EAE) animal model. However, precise role of neutrophils cervical lymph nodes (CLNs), primary CNS-draining where response is initiated during progression EAE, remains poorly understood.
Abstract Background Duchenne muscular dystrophy (DMD) is an X-linked, incurable, degenerative neuromuscular disease that exacerbated by secondary inflammation. N 6 -methyladenosine (m A), the most common base modification of RNA, has pleiotropic immunomodulatory effects in many diseases. However, role m A immune microenvironment DMD remains elusive. Methods Our study retrospectively analyzed expression data 56 muscle tissues from patients and 26 non-muscular individuals. Based on single...