A5035252914- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Plant-Microbe Interactions and Immunity
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Postharvest Quality and Shelf Life Management
- Plant Pathogens and Fungal Diseases
- Fibroblast Growth Factor Research
- Nanocomposite Films for Food Packaging
- Macrophage Migration Inhibitory Factor
- interferon and immune responses
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Hair Growth and Disorders
- Photoreceptor and optogenetics research
- Legume Nitrogen Fixing Symbiosis
- Redox biology and oxidative stress
- Allelopathy and phytotoxic interactions
- Weed Control and Herbicide Applications
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Plant Gene Expression Analysis
- Leaf Properties and Growth Measurement
Hebei Medical University
2019-2024
Second Hospital of Hebei Medical University
2019-2024
Jinzhong University
2021
Shanxi Agricultural University
2017
Hebei Provincial Center for Disease Control and Prevention
2016
Shandong University
2012-2014
Haploinsufficiency of the protein kinase Tbk1 has shown to cause both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, pathogenic mechanisms are unclear. Here we show that conditional neuronal deletion in leads cognitive locomotor deficits mice. Tbk1-NKO mice exhibited numerous neuropathological changes, including neurofibrillary tangles, abnormal dendrites, reduced dendritic spine density, cortical synapse loss. The Purkinje cell layer cerebellum presented...
Abstract Glioblastoma (GBM) is the most common malignant diffuse glioma of brain. Although immunotherapy with immune checkpoint inhibitors (ICIs), such as programmed cell death protein (PD)‐1/PD ligand‐1 inhibitors, has revolutionized treatment several cancers, clinical benefit in GBM patients been limited. Lymphocyte‐activation gene 3 (LAG‐3) binding to human leukocyte antigen‐II (HLA‐II) plays an essential role triggering CD4 + T exhaustion and could interfere efficiency anti‐PD‐1...
In order to assess its response the herbicide, sethoxydim (SEY), seedlings of two foxtail millet (Setaria italica) hybrids were exposed 0.75, 1.5, 3, and 6 L(SEY active ingredient, ai) ha-1 for 7 15 d. Our results showed that SEY reduced photosynthesis oxidative stress in hybrid (Zhangza) at dosage below 1.5 L(ai) (i.e., recommended dosage), whereas it caused death Jingu 21 all treatment dosages. addition, we further explored effect on PSI PSII; a greater tolerance also ability recover....
Abstract Fibroblast growth factor 9 (FGF9) has long been assumed to modulate multiple biological processes, yet very little is known about the impact of FGF9 on neurodevelopment. Herein, we found that loss Fgf9 in olig1 progenitor cells induced epilepsy mice, with pathological changes cortex. Then depleting different neural populations revealed was associated GABAergic neurons. CKO neuron (CKO VGAT ) mice exhibited not only most severe seizures, but also retardation and highest mortality....
TANK binding kinase 1 (TBK1) is an important that involved in innate immunity and tumor development. Macrophage colony‐stimulating factor (M‐CSF) regulates the differentiation function of macrophages towards immunosuppressive M2 phenotype glioblastoma multiforme microenvironment. The role TBK1 macrophages, especially regulating macrophage polarization response to M‐CSF stimulation, remains unclear. Here, we found high expression human glioma‐infiltrating myeloid cells phosphorylated was...
The aim of this study was to conduct a bibliometric analysis the relevant literature on Duchenne muscular dystrophy (DMD) ascertain its current status, identify key areas research and demonstrate evolution field.
Foxtail millet (Setaria italica (L.) P. Beauvois) is a high-nutrition food source.It commonly consumed in Africa, Asia, Central America, and South America.The key to popularize high-quality foxtail accordance with local conditions quantifying the impacts of cultivation on its quality.Here, we determined effects different fertilizer levels nitrogen (N), tetraphosphorus decaoxide (P2O5), potassium oxide (K2O), tribenuron-methyl (TBM) herbicide, selenium (Se) quality Jingu 54 using quadratic...