A5100724921- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Cancer-related Molecular Pathways
- Gene expression and cancer classification
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Cutaneous Melanoma Detection and Management
- Cancer Mechanisms and Therapy
- Coenzyme Q10 studies and effects
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- Cancer Immunotherapy and Biomarkers
- Mesenchymal stem cell research
- Neuroblastoma Research and Treatments
- PARP inhibition in cancer therapy
- Viral-associated cancers and disorders
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Drug Transport and Resistance Mechanisms
Central South University
2024
National Institute of Environmental Health Sciences
2015-2023
Research Triangle Park Foundation
2023
Binzhou Medical University
2018-2022
Guangdong Pharmaceutical University
2020-2022
Binzhou University
2018-2022
Zhejiang University
2014-2021
Sichuan University
2021
Hebei Medical University
2021
Second Hospital of Hebei Medical University
2021
Abstract Background & aims Immunotherapy with hepatitis B virus (HBV)-specific TCR redirected T (HBV-TCR-T) cells in HBV-related hepatocellular carcinoma (HBV-HCC) patients after liver transplantation was reported to be safe and had potential therapeutic efficacy. We aim investigate the safety of HBV-TCR-T-cell immunotherapy advanced HBV-HCC who not met criteria for transplantation. Methods enrolled eight adoptively transferred short-lived autologous expressing HBV-specific perform an...
Quantifying cell-type proportions and their corresponding gene expression profiles in tissue samples would enhance understanding of the contributions individual cell types to physiological states tissue. Current approaches that address heterogeneity have drawbacks. Experimental techniques, such as fluorescence-activated sorting, single RNA sequencing are expensive. Computational use data from heterogeneous promising, but most current methods estimate either or cell-type-specific by requiring...
Aim: Aberrant epigenetic events are important contributors to the pathogenesis of different types cancers and dietary botanicals with properties can influence early cancer development leading prevention effects. We sought investigate potential combinatorial effects bioactive components including green tea polyphenols (GTPs) broccoli sprouts (BSp) on neutralizing aberrations during breast tumorigenesis. Materials & methods: The were evaluated in a transformation cellular system mouse...
DNASE1L3, an enzyme highly expressed in DCs, is functionally important for regulating autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3 leads development diseases both humans mice. However, despite the well-established causal relationship between immunity, little known about involvement regulation antitumor foundation modern immunotherapy. In this study, we identify as a potentially new regulator immunity tumor suppressor colon cancer. humans, downregulated...
Primary and metastatic melanoma tumors share the same cell origin, making it challenging to identify genomic biomarkers that can differentiate them. themselves be heterogeneous, reflecting ongoing changes as they progress toward metastasizing. We developed a computational method explore this heterogeneity predict progression of primary tumors. applied our separately gene expression microRNA (miRNA) data from ~450 skin cutaneous (SKCM) samples Cancer Genome Atlas (TCGA). Metastatic scores...
Due to the poor prognosis of advanced metastatic melanoma, it is crucial find early biomarkers that help identify which melanomas will metastasize. By comparing gene expression data from primary and cutaneous melanoma samples The Cancer Genome Atlas (TCGA), we identified GPC6 among a set genes whose levels can distinguish between regional cutaneous/subcutaneous metastases. Glypicans are thought play role in tumor growth by regulating signaling pathways Wnt, Hedgehogs, fibroblast factors...
Treating colorectal cancer (CRC) continues to be a clinical challenge. Coptisine, an alkaloid derived from Coptis chinensis Franch. shows toxic effects on CRC cells, but its underlying mechanism remains elusive. MFG-E8 is involved in tumor growth and progression. Herein, we evaluated the of coptisine CRC, explored mechanism. The expression adjacent normal colon tissue samples patients was detected. cells HCT116 vitro were by CCK-8, adhesion transwell assays. A xenograft model used assess...
The application of hepatitis B virus (HBV)–T‐cell receptor (TCR) T‐cell immunotherapy in patients with HBV‐related hepatocellular carcinoma (HBV‐HCC) has been apathetic, as the expression HBV antigens by both normal HBV‐infected hepatocytes and HCC cells HBV‐DNA integration increases risk on‐target off‐tumor severe liver inflammatory events. To increase safety this immunotherapeutic approach, we developed messenger RNA (mRNA) HBV‐TCR‐redirected T that—due to transient nature mRNA—are...
Carthamus tinctorius L. is a traditional Chinese medicine that activates blood circulation and dissipates stasis, has been extensively used as antitumor treatment in clinical setting single or compound preparation form. However, empirical evidence better understanding of the possible mechanisms involved are still required. Here, we investigated role safflower yellow (SY), active ingredient C. tinctorius, pulmonary metastasis breast cancer, underlying mechanism action. EGF-meditated time-...
Lung cancer is the top killer worldwide.Tyrosine kinase inhibitors (TKIs), for example erlotinib, are commonly used to target epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (ADC).Autophagy a cellular response stress, serving as protective mechanism during anticancer therapy.The tumor microenvironment (TME) composed of non-tumor cells that include fibroblasts.Our study aimed investigate effect TME on autophagy and TKI sensitivity.Following cell sorting after direct...
Neurogenic locus notch homolog protein (Notch) signaling mediates intracellular communication and may regulate cell fate decisions, including proliferation, differentiation, apoptosis. Mesenchymal stem cells (MSCs) possess immunomodulatory properties the potential for use in replacement treatments. The aim of present study was to evaluate therapeutic effects human placenta‑deviated MSCs (hPMSCs) asthma investigate mechanisms Notch mediated by transplanted MSCs. A Sprague‑Dawley rat ovalbumin...
High-risk endometrial cancers (ECs), including high-grade EC, serous carcinoma (SC), clear cell carcinoma, and carcinosarcoma, account for 50% of deaths due to ECs. Therapies these are limited, patient-derived tumor xenograft (PDTX) models useful tools preclinical drug evaluation, biomarker identification, personalized medicine strategies. Here, we used compared 2 methods establish PDTX models.Fresh tissues collected from 18 primary high-risk EC patients (10 ECs, 6 SCs, 1 carcinosarcoma)...
Colorectal cancer (CRC) is one of the leading causes cancer-related death worldwide. Decylubiquinone (DUb), a coenzyme Q10 analog, was reported to inhibit breast growth and metastasis by us. However, influence DUb on CRC remains unclear. Herein, we found that significantly inhibited in patient-derived xenograft (PDX) CT26 models. further identified suppress cell proliferation, colony formation, migration invasion dose-dependent manner, while not inhibiting apoptosis from flow cytometry...
Abstract Summary: Elucidation of human disease similarities has provided new insights into etiology, classification and drug repositioning. Since dysfunctional regulation would be manifested as the decoupling expression correlation, similarity (DS) in terms mechanism (DRM) could estimated by using a differential coexpression based approach, which is described companion paper. Due to lack tools for estimating DS from viewpoint DRM public domain, we implemented an R package ‘DSviaDRM’ identify...
Abstract Background Breast cancer is the most common among women in China. Amplification of Human epidermal growth factor receptor type 2 (HER2) gene present and overexpressed 18–20% breast cancers historically has been associated with inferior disease-related outcomes. There increasing interest de-escalation therapy for low-risk disease. This study analyzes cost-effectiveness Doxorubicin/ Cyclophosphamide/ Paclitaxel/ Trastuzumab (AC-TH) Docetaxel/Carboplatin/Trastuzumab(TCH) from payer...
Abstract Background Chemo-resistance is still a major obstacle in leukemia treatment. Accumulating evidence indicates that cancer-associated fibroblasts (CAFs), the most abundant stromal cells tumor microenvironment (TME), play crucial role cancer progression and response to chemotherapy. To Figure out of leukemia-associated (LAFs) relapsed/refractory leukemia, we constructed first fibroblastic cell line, HXWMF-1. Methods A culture technique was used establish line. Molecular cellular...
Waldenstrom's macroglobulinemia (WM), a lymphoplasmacytic lymphoma and immunoglobulin M (IgM) monoclonal gammopathy, is subtype of plasma cell disorder, an indolent mature B-cell neoplasm associated with bone marrow involvement1. Pure red aplasia (PRCA) characterised by the near complete absence erythroid precursors in but normal megakaryocytes granulocytes2. About 80% cases WM are complicated normocytic normochromic anaemia, while PRCA, unusual cause anaemia patients chronic...