A5017181809- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- TGF-β signaling in diseases
- Immune Response and Inflammation
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Immunodeficiency and Autoimmune Disorders
- MicroRNA in disease regulation
- Psoriasis: Treatment and Pathogenesis
- Monoclonal and Polyclonal Antibodies Research
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cytomegalovirus and herpesvirus research
- Inflammasome and immune disorders
- Virus-based gene therapy research
- Galectins and Cancer Biology
- IL-33, ST2, and ILC Pathways
- Complement system in diseases
University of North Carolina at Chapel Hill
2014-2024
UNC Lineberger Comprehensive Cancer Center
2010-2024
Segeberger Kliniken
2011-2020
Xuzhou Medical College
2014
Yale University
2005-2013
Indiana University School of Medicine
2010-2011
Bipar
2008
Howard Hughes Medical Institute
2005-2008
University of Colorado Health
2000-2004
University of Colorado Anschutz Medical Campus
2000
Regulatory T cells are critical for maintaining self-tolerance and to negatively regulate immune responses. Foxp3 is a regulatory cell-specific transcription factor that functions as the master regulator of development function cells. Here, we report generation mouse model, in which bicistronic reporter expressing red fluorescent protein has been knocked into endogenous locus. Using this assessed expression various lymphocyte compartments identified previously unreported Foxp3-expressing In...
Combining whole exome sequencing, transcriptome profiling, and T cell repertoire analysis, we investigate the spatial features of surgically-removed biopsies from multiple loci in tumor masses 15 patients with non-small lung cancer (NSCLC). This revealed that immune microenvironment has high heterogeneity such intratumoral regional variation is as large inter-personal variation. While local total mutational burden (TMB) associated T-cell clonal expansion, anti-tumor cytotoxicity does not...
Abstract Enhancer of zeste homolog (EZH2) is a key epigenetic regulator gene expression and frequently overexpressed in various cancer types, suggesting role oncogenesis. The therapeutic potential EZH2 inhibitors currently being explored, but their effect on antitumor immunity largely unknown. Here we report that suppressing activity using inhibitor GSK126 resulted increased numbers myeloid-derived suppressor cells (MDSC) fewer CD4+ IFNγ+CD8+ T cells, which are involved immunity. Addition...
The role of direct IL-10 signaling in different T cell subsets is not well understood. To address this, we generated transgenic mice expressing a dominant-negative receptor specifically cells (CD4dnIL-10Rα). We found that Foxp3-depleted CD45RBlo (regulatory [Treg cell]–depleted CD45RBlo) but CD45RBhi CD4+ are controlled directly by upon transfer into Rag1 knockout (KO) mice. Furthermore, the colitis induced Treg cell–depleted KO was characterized reduced Th1 and increased Th17 cytokine...
Enhancer of zeste homolog 2 (EZH2)-mediated trimethylation histone 3 lysine 27 (H3K27Me3) is critical for immune regulation. However, evidence lacking to address the effect EZH2 enzyme's activity on intestinal responses during inflammatory bowel disease (IBD). Here we report that suppressing ameliorates experimental inflammation and delayed onset colitis-associated cancer. In addition, identified an increased number functional MDSCs in colons, which are essential inhibitor activity....
As a hallmark of immunological aging, low-grade, chronic inflammation with accumulation effector memory T cells contributes to increased susceptibility many aging-related diseases. While the proinflammatory state aged indicates dysregulation immune homeostasis, whether and how aging drives regulatory cell (Treg) alters Treg function are not fully understood owing lack specific markers. Here, by combination cellular, molecular, bioinformatic approaches, we discovered that Tregs senesce more...
IL-10 is essential to maintain intestinal homeostasis. CD4+ T regulatory type 1 (TR1) cells produce large amounts of this cytokine and are therefore currently being examined in clinical trials as cell therapy patients with inflammatory bowel disease. However, factors molecular signals sustaining TR1 activity still need be identified optimize the efficiency ensure safety these trials. We investigated role signaling mature vivo. Double IL-10eGFP Foxp3mRFP reporter mice transgenic impairment...