A5075552286- Immune Response and Inflammation
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Systemic Lupus Erythematosus Research
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Peripheral Neuropathies and Disorders
- Autophagy in Disease and Therapy
- Nicotinic Acetylcholine Receptors Study
- Immune Cell Function and Interaction
- interferon and immune responses
- Macrophage Migration Inhibitory Factor
- Immunodeficiency and Autoimmune Disorders
- Ichthyology and Marine Biology
- Lipid metabolism and disorders
- Sarcoma Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Meningioma and schwannoma management
- Connexins and lens biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Lipids, and Metabolism
- Vagus Nerve Stimulation Research
- IL-33, ST2, and ILC Pathways
Nanjing Medical University
2018-2025
Jiangsu Province Hospital
2025
Nanjing Agricultural University
2020-2024
University of Delaware
2018-2024
Zunyi Medical University
2020-2024
Anhui Medical University
2021-2024
First Affiliated Hospital of Anhui Medical University
2024
Thomas Jefferson University
2022-2023
Shandong University
2021-2022
Chinese University of Hong Kong
2022
Purpose: Lens epithelial cell (LEC) conversion to myofibroblast is responsible for fibrotic cataract surgery complications including posterior capsular opacification. While transforming growth factor beta (TGFβ) signaling important, the mechanisms by which TGFβ pathway activated post (PCS) are not well understood. Methods: RNA-seq was performed on LECs obtained from a mouse model at time of and 24 hours later. Bioinformatic analysis with iPathwayGuide. Expression dynamics were determined...
Immune cells infiltrate the peripheral nervous system (PNS) after injury and with autoimmunity, but their net effect is divergent. After injury, immune are reparative, while in inflammatory neuropathies (e.g., Guillain Barré Syndrome chronic demyelinating polyneuropathy), proinflammatory promote autoimmune demyelination. An understanding of cell phenotypes that distinguish these conditions may, therefore, reveal new therapeutic targets for switching from an role to a reparative state. In...
This study aims to investigate the associations between MTNR1B rs724030 A>G variant and prediabetes risk, along with their correlations clinical features, including plasma glucose serum insulin levels during oral tolerance test (OGTT), islet function, resistance, lipid levels. In particular, we investigated whether there are sex dimorphisms in impact of this on function/insulin resistance. We included 3415 glucose-tolerant healthy 1744 individuals based OGTT. Binary logistic regression was...
p38 MAPK (mitogen-activated protein kinase) is a critical regulator in lung inflammation. It can be inactivated by DUSP1 (dual-specificity phosphatase 1) which was identified as putative target of miR-429. miR-429 mimics directly targeted to the 3′-UTR gene encoding may result translational attenuation DUSP1. Moreover, phosphorylation prolonged after mimic treatment. Additionally, expression sensitive LPS (lipopolysaccharide) stimulation and increased production pro-inflammatory cytokines....
Chronic inflammatory demyelinating polyneuropathy (CIDP) and Guillain-Barre syndrome (GBS) are neuropathies that affect humans characterized by peripheral nerve myelin destruction macrophage-containing immune infiltrates. In contrast to the traditional view is simply target of autoimmunity, we report here Schwann cells exacerbate autoimmune process through extracellular matrix (ECM) protein induction. a spontaneous (SAPP) mouse model neuropathy CIDP biopsies, ECM periostin (POSTN) was...
Ischemic stroke is a leading cause of death and disability worldwide. However, the time window for quickly dissolving clots restoring cerebral blood flow, using tissue-type plasminogen activator treatment rather limited, resulting in many patients experiencing long-term functional impairments if not death. This study aims to determine roles cranial bone transport (CBT), novel, effective, simple surgical technique, recovery ischemic middle artery occlusion (MCAO) rat model.CBT was performed...
Significance Archaeorhynchus spathula is a basal member of the Ornithuromorpha, lineage that includes neornithines. Although this fifth reported specimen, unlike others it preserves significant soft tissue, revealing tail morphology previously unknown in Mesozoic birds and an exceptional occurrence fossilized lung tissue. This identification based on topographical location anatomical features revealed mainly by scanning electron microscopy. A structure similar to neornithines indicates...
Abstract Background Secondary brain damage caused by the innate immune response and subsequent proinflammatory factor production is a major contributing to high mortality of intracerebral haemorrhage (ICH). Nucleotide-binding oligomerization domain 1 (NOD1)/receptor-interacting protein 2 (RIP2) signalling has been reported participate in inflammatory response. Therefore, we investigated role NOD1/RIP2 mice with collagenase-induced ICH cultured primary microglia challenged hemin. Methods...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) has been shown to have protective effects against atherosclerosis. However, whether TRAIL any on expression of macrophage scavenger receptors and lipid uptake not yet studied. Macrophage lines RAW264.7 THP-1, mouse primary peritoneal macrophages, were cultured in vitro treated with recombinant human TRAIL. Real-time PCR western blot performed measure mRNA protein expressions. Foam cell formation was assessed by...
Abstract Chronic inflammatory demyelinating polyneuropathy (CIDP) is a debilitating condition caused by autoimmune demyelination of peripheral nerves. CIDP associated with increased IL-10, cytokine well-described anti-inflammatory effects. However, the role IL-10 in unclear. In this study, we demonstrate that paradoxically exacerbates autoimmunity against IL-10–deficient mice, protection from neuropathy was an accrual highly activated CD4+ T cells draining lymph nodes and absence...
Intraluminal thrombus (ILT) signal intensity on MRI has been studied as a potential marker of abdominal aortic aneurysm (AAA) progression.1) To characterize the relationship between ILT and AAA diameter; 2) to evaluate change over time; 3) assess features growth.Prospective.Eighty patients were imaged, subset (n = 41) followed with repeated for 16 ± 9 months.3D black-blood fast-spin-echo sequence at 3 T.ILT was designated "bright" if greater than 1.2 times that adjacent psoas muscle. AAAs...