A5101930576- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- MicroRNA in disease regulation
- Plant responses to water stress
- Phytochemistry and Bioactive Compounds
- Phytochemical Studies and Bioactivities
- Medicinal Plants and Bioactive Compounds
- Bone Metabolism and Diseases
- Pharmacological Effects of Natural Compounds
- Plant-Microbe Interactions and Immunity
- Legume Nitrogen Fixing Symbiosis
- Traditional Chinese Medicine Analysis
- Mycorrhizal Fungi and Plant Interactions
- Fungal Biology and Applications
- Photosynthetic Processes and Mechanisms
- Dental Implant Techniques and Outcomes
- Cerebrospinal fluid and hydrocephalus
- Microbial Natural Products and Biosynthesis
- Plant Pathogenic Bacteria Studies
- Toxin Mechanisms and Immunotoxins
- Spinal Dysraphism and Malformations
- Plant-based Medicinal Research
- Genetic diversity and population structure
- Biochemical and Molecular Research
- Kruppel-like factors research
Shanghai University of Sport
2025
Chinese University of Hong Kong
2021-2025
Prince of Wales Hospital
2022-2025
Chinese Academy of Sciences
2025
Baylor College of Medicine
2010-2024
Columbia University Irving Medical Center
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Hebei Medical University
2024
State Key Laboratory for Innovation and Transformation of Luobing Theory
2024
Dalian University
2024
Despite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors (KRASi) remains a major barrier progress. Here, we report proteostasis reprogramming as key convergence point of multiple KRASi-resistance mechanisms. Inactivation oncogenic down-regulated both the heat shock response and inositol-requiring enzyme 1α (IRE1α) branch unfolded protein response, causing severe disturbances. However, IRE1α was selectively reactivated an ER stress–independent manner acquired...
Abstract Loss of protein function is a driving force ageing. We have identified peptidyl-prolyl isomerase A (PPIA or cyclophilin A) as dominant chaperone in haematopoietic stem and progenitor cells. Depletion PPIA accelerates cell found that proteins with intrinsically disordered regions (IDRs) are frequent substrates. IDRs facilitate interactions other nucleic acids can trigger liquid–liquid phase separation. Over 20% substrates involved the formation supramolecular membrane-less...
While most commonly associated with its role in gibberellin phytohormone biosynthesis, ent-kaurene also serves as an intermediate more specialized diterpenoid metabolism, exemplified by the than 800 known derived natural products. Among these are maize kauralexins. However, no synthases (KSs) have been identified from maize. The gibberellin-deficient dwarf-5 (d5) mutant has a loss of KS activity. relevant genetic lesion previously mapped, and was found here to correlate location KS-like gene...
Among their responses to microbial infection, plants deploy an arsenal of natural antibiotic products. Historically these have been identified on the basis activity in vitro, which leaves open question relevance defense planta. The vast majority such products from important crop plant rice (Oryza sativa) are diterpenoids whose biosynthesis proceeds via either ent- or syn-copalyl diphosphate (CPP) intermediates, were isolated against fungal blast pathogen Magnaporthe oryzae. However, gene for...
Bacterial interactions with plants are accompanied by complex signal exchange processes. Previously, the nitrogen-fixing symbiotic (rhizo)bacterium Bradyrhizobium japonicum was found to carry adjacent genes encoding two sequentially acting diterpene cyclases that together transform geranylgeranyl diphosphate ent-kaurene, olefin precursor gibberellin plant hormones. Species from three other major genera of rhizobia were have homologous terpene synthase genes. Cloning and functional...
Abstract INTRODUCTION Alzheimer's disease (AD) is a progressive neurodegenerative and the leading cause of dementia. Recent research highlights meningeal lymphatics as key regulators in neurological diseases, suggesting that enhancing their drainage function could be potential therapeutic strategy for AD. Our proof‐of‐concept study demonstrated cranial bone transport can improve lymphatic promote ischemic stroke recovery. METHODS This defined maneuver (CBM) technique. After osteotomy, small...
Ischemic stroke is a leading cause of death and disability worldwide. However, the time window for quickly dissolving clots restoring cerebral blood flow, using tissue-type plasminogen activator treatment rather limited, resulting in many patients experiencing long-term functional impairments if not death. This study aims to determine roles cranial bone transport (CBT), novel, effective, simple surgical technique, recovery ischemic middle artery occlusion (MCAO) rat model.CBT was performed...
Osteoporosis, a common systematic bone homeostasis disorder related disease, still urgently needs innovative treatment methods. Several natural small molecules were found to be effective therapeutics in osteoporosis. In the present study, quercetin was screened out from library of molecular compounds by dual luciferase reporter system. Quercetin upregulate Wnt/β-catenin while inhibiting NF-κB signaling activities, and thereby rescuing osteoporosis-induced tumor necrosis factor alpha (TNFα)...
Summary Both plants and fungi produce ent ‐kaurene as a precursor to the gibberellin plant hormones. A number of rhizobia contain functionally conserved, sequentially acting ‐copalyl diphosphate synthases (CPS KS, respectively), which are found within well‐conserved operon that may lead production gibberellins. Intriguingly, rice bacterial leaf streak pathogen Xanthomonas oryzae pv. oryzicola (Xoc) contains homologous operon. Here, we report biochemical characterization encoded CPS KS ,...
Abstract Aberrant epigenetic reprogramming represents a hallmark of renal cell carcinoma (RCC) tumorigenesis and progression. Whether there existed other vulnerabilities that could serve as therapeutic targets remained unclear promising. Here, we combined the clustered regularly interspaced short palindromic repeats functional screening results multiple RCC datasets to identify JMJD6 potent target in RCC. expression correlated with poor survival outcomes patients promoted progression vitro...
Osteoporotic fracture has been regarded as one of the most common bone disorders in aging society. The natural herb-derived small molecules were revealed potential treatment approaches for osteoporotic healing. Sesamin is a member lignan family, which possesses estrogenic activity and plays significant role modulating homeostasis. Our previous study reported promoting effect sesamin on postmenopausal osteoporosis treatment. However, healing not well studied yet. In this study, we further...
Cerebral edema, erupting simultaneously with severe ischemic stroke, might lead to increased intracranial pressure, cerebral herniation, and ultimately death. Studies conducted previously by our team have demonstrated the fact that bloodletting puncture at hand twelve Jing-well points (HTWP) could alleviate which mainly results from disruption of blood-brain barrier (BBB). The study, therefore, was first designed demonstrate whether BBB-protection serves an important role in edema-relief...
As one of the leading causes bone fracture in postmenopausal women and older men, osteoporosis worldwide is attracting more attention recent decades. Osteoporosis a common disease mainly resulting from an imbalance formation resorption. Pharmaceutically active compounds that both activate osteogenesis, while repressing osteoclastogenesis hold potential being therapeutic medications for treatment. In present study, sesamin, bioactive ingredient derived seed Sesamum Indicum, was screened out...
A new quinazolinone alkaloid, named peniquinazolinone (1), as well eleven known compounds, 2-(2-hydroxy-3-phenylpropionamido)-N-methylbenzamide (2), viridicatin (3), viridicatol (4), (±)-cyclopeptin (5a/5b), dehydrocyclopeptin (6), cyclopenin (7), cyclopenol (8), methyl-indole-3-carboxylate (9), 2,5-dihydroxyphenyl acetate (10), methyl m-hydroxyphenylacetate (11), conidiogenone B (12), was isolated from the endophytic Penicillium sp. HJT-A-6 derived stem of Rhodiola tibetica. The chemical...
Two new steroidal saponins were isolated from the fruits of Tribulus terrestris L. Their structures elucidated by spectroscopic and chemical analysis as (23S,24R,25R)-5α-spirostane-3β,23,24-triol-3-O-{α-l-rhamnopyranosyl-(1 → 2)-[β-d-glucopyranosyl-(1 4)]-β-d-galactopyranoside} (1) (23S,24R,25S)-5α-spirostane-3β,23,24-triol-3-O-{α-l-rhamnopyranosyl-(1 (2).