A5038846608- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- HIV-related health complications and treatments
- HIV Research and Treatment
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- Trace Elements in Health
- Nitric Oxide and Endothelin Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Virus-based gene therapy research
- Chemokine receptors and signaling
- Signaling Pathways in Disease
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Cellular Mechanics and Interactions
- Neuroendocrine Tumor Research Advances
- Atherosclerosis and Cardiovascular Diseases
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Axon Guidance and Neuronal Signaling
- Immune Cell Function and Interaction
- Neuroblastoma Research and Treatments
Stony Brook School
2025
Stony Brook University
2025
Baylor College of Medicine
2015-2024
Michael E. DeBakey VA Medical Center
2009-2024
University of Electronic Science and Technology of China
2024
Zhejiang University
2024
First Affiliated Hospital Zhejiang University
2024
University of Science and Technology of China
2020
Children's Cancer Center
2016
China Medical University
2013
Despite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors (KRASi) remains a major barrier progress. Here, we report proteostasis reprogramming as key convergence point of multiple KRASi-resistance mechanisms. Inactivation oncogenic down-regulated both the heat shock response and inositol-requiring enzyme 1α (IRE1α) branch unfolded protein response, causing severe disturbances. However, IRE1α was selectively reactivated an ER stress–independent manner acquired...
Objective— Recent studies have illustrated that mesenchymal stem cells possess the potential to differentiate along an endothelial lineage, but effect of shear on differentiation is unknown. Thus, we developed in vitro stress system examine relationship between and a murine embryonic progenitor cell line, C3H/10T1/2. Methods Results— The parallel plate fluid was used. Shear significantly induced expression mature cell–specific markers CH3H/10T1/2 such as CD31, von Willebrand factor, vascular...
Zinc is an essential trace element and catalytic/structural component used by many metalloenzymes transcription factors. Recent studies indicate a possible correlation of zinc levels with the cancer risk; however, exact role transporters in progression unknown. We have observed that transporter, ZIP4 (SLC39A4), was substantially overexpressed 16 17 (94%) clinical pancreatic adenocarcinoma specimens compared surrounding normal tissues, mRNA expression significantly higher human cells than...
Resistin is a newly discovered adipocyte-derived cytokine that may play an important role in insulin resistance, diabetes, adipogenesis, inflammation, and cardiovascular disease. However, it largely unknown whether resistin impairs endothelial functions by affecting the nitric oxide synthase (eNOS) system. In this study, we determined effect of human recombinant protein on eNOS expression regulation coronary artery cells (HCAECs). When were treated with clinically relevant concentrations (40...
Abstract Background Trop2 is a cell-surface glycoprotein overexpressed by variety of epithelial carcinomas with reported low to restricted expression in normal tissues. Expression has been associated increased tumor aggressiveness, metastasis and decreased patient survival, but the signaling mechanisms mediated are still unknown. Here, we studied effects murine (mTrop2) exerted on cellular functions some activated this oncogene. Results mTrop2 significantly cell proliferation at serum...
Given the high fatality rate of pancreatic cancer, an effective treatment for this devastating disease is urgently needed. We have shown that mesothelin expression was higher in human cancer cells than duct epithelial cells, and mRNA substantially overexpressed 18 21 (86%) clinical adenocarcinoma specimens when compared with surrounding normal tissues. However, biological functions tumor progression are not clearly understood. Here we studied effects overexpression cell proliferation...
Abstract Background Previous studies showed that mesothelin (MSLN) plays important roles in survival of pancreatic cancer (PC) cells under anchorage dependent/independent conditions as well resistance to chemotherapy. The recent success intratumorally-injected adeno-encoded, chemo/radiation-inducible-promoter driven hTNF-α, (TNFerade) + gemcitabine pre-clinical models PC have renewed interest use TNF-α a therapeutic component. To help find additional factors which might affect the therapy,...
Abstract BACKGROUND Although overexpression of cyclophilin A (CypA) is associated with several types cancer, its role in pancreatic cancer has not been studied. In this study the expression CypA and receptor CD147 on was determined as well effect exogenous cell proliferation. METHODS The human lines tissues real‐time reverse transcriptase polymerase chain reaction (RT‐PCR), Western blot, immunostaining. Cell proliferation response to performed by [ 3 H]thymidine incorporation assay....
Objective— Although HIV protease inhibitors have been successfully used against infection, many metabolic side effects and premature cardiovascular diseases are often associated with this therapy. The mechanisms of these complications not clear. In study, we investigated the effect inhibitor ritonavir on human endothelial cell cultures. Methods Results— By using nonradioactive proliferation cytotoxicity assays, cells treated showed a significant decrease in viability an increase time-...