A5100653048- Metabolomics and Mass Spectrometry Studies
- Pharmacogenetics and Drug Metabolism
- Cholinesterase and Neurodegenerative Diseases
- HIV-related health complications and treatments
- Mass Spectrometry Techniques and Applications
- Nitric Oxide and Endothelin Effects
- Ginseng Biological Effects and Applications
- Computational Drug Discovery Methods
- Foot and Ankle Surgery
- Liver Disease Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- RNA Research and Splicing
- Drug Transport and Resistance Mechanisms
- Aortic aneurysm repair treatments
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Diabetic Foot Ulcer Assessment and Management
- Pharmaceutical Economics and Policy
- HIV/AIDS drug development and treatment
- Epigenetics and DNA Methylation
- Aortic Disease and Treatment Approaches
- HIV Research and Treatment
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
Northeast Ohio Medical University
2021-2024
Xiangya Hospital Central South University
2020-2024
Hainan University
2022-2024
Central South University
2020-2024
Yangzhou University
2023-2024
Ningbo University
2024
Lanzhou University of Technology
2024
BGI Group (China)
2024
Hunan University of Science and Technology
2022-2024
Ningbo University Affiliated Hospital
2024
Zinc is an essential trace element and catalytic/structural component used by many metalloenzymes transcription factors. Recent studies indicate a possible correlation of zinc levels with the cancer risk; however, exact role transporters in progression unknown. We have observed that transporter, ZIP4 (SLC39A4), was substantially overexpressed 16 17 (94%) clinical pancreatic adenocarcinoma specimens compared surrounding normal tissues, mRNA expression significantly higher human cells than...
Resistin is a newly discovered adipocyte-derived cytokine that may play an important role in insulin resistance, diabetes, adipogenesis, inflammation, and cardiovascular disease. However, it largely unknown whether resistin impairs endothelial functions by affecting the nitric oxide synthase (eNOS) system. In this study, we determined effect of human recombinant protein on eNOS expression regulation coronary artery cells (HCAECs). When were treated with clinically relevant concentrations (40...
Clopidogrel pharmacotherapy is associated with substantial interindividual variability in clinical response, which can translate into an increased risk of adverse outcomes. Clopidogrel, a recognized substrate hepatic carboxylesterase 1 (CES1), undergoes extensive hydrolytic metabolism the liver. Significant expression and activity CES1 exists, attributed to both genetic environmental factors. We determined whether inhibition <i>CES1</i> polymorphisms would significantly influence...
Immunogenic cell death (ICD) has been classified as a form of regulated (RCD) that is sufficient to activate an adaptive immune response. Accumulating evidence demonstrated the ability ICD reshape tumor microenvironment through emission danger signals or DAMPs, which may contribute immunotherapy. Currently, identification ICD-associated biomarkers stratify patients according their benefit from immunotherapy would be great advantage. Here, we identified two subtypes by consensus clustering....
Abstract Background tRNA-derived fragments (tRFs) have been shown to critical regulatory roles in cancer biology. However, the contributions of tRFs colorectal (CRC) remain largely unknown. Methods tRF3008A (a tRFRNA derived from tRNA Val ) was identified by RNA sequencing and validated quantitative reverse transcription PCR. The role CRC progression assessed both vitro vivo, its downstream target genes were cells. pull-down with mass spectrometry AGO-RIP used confirm interaction AGO...
Tumor microenvironment (TME) heterogeneity leads to a discrepancy in survival prognosis and clinical treatment response for patients with HCC. The applications of documented molecular subtypes are constrained by several issues.
The key feature of metabolic syndrome, a cluster and cardiovascular disorders, is systemic insulin resistance, which associated with dysregulated endothelial nitric-oxide synthase (eNOS). Stress signaling induced by inflammation can inhibit signaling. However, molecular mechanisms for the cross-talk between stress resistance are only partially understood. Resistin, an adipokine/cytokine, involved in inflammatory processes that could lead to status vascular diseases. In current study, we...
Thoracic aortic dissection (TAD) is characterized by dysregulated extracellular matrix. Little known about the alterations of collagen and stimulators synthesis, eg, connective tissue growth factor (CTGF), in patients with TAD. In this study, we examined their roles TAD.Surgical specimens wall TAD (n=10) controls were tested for types I III CTGF expression. When compared controls, protein levels type significantly increased 3.2-, 3.7-, 5.3-fold, respectively (P<0.05 all). Similar patterns...
Early diagnosis of diabetic nephropathy (DN) is difficult although it crucial importance to prevent its development. To probe potential markers and the underlying mechanism DN, an animal model db/db mice, was used serum urine metabolites were profiled using gas chromatography/time-of-flight mass spectrometry. Metabolic patterns evaluated based on data. Principal component analysis data revealed obvious metabonomic difference between mice controls, showed distinctly different metabolic during...
Previous expression quantitative trait loci (eQTL) studies have identified thousands of genetic variants to be associated with gene at the mRNA level in human liver. However, protein often correlates poorly levels. Thus, (pQTL) study is required identify that regulate livers.
Histone acetylation plays an important role in chromatin remodeling and gene expression. The molecular mechanisms involved cell-specific expression of endothelial nitric-oxide synthase (eNOS) are not fully understood. In this study we investigated whether histone deacetylation was repression eNOS non-endothelial cells. Induction by deacetylase (HDAC) inhibitors trichostatin A (TSA) sodium butyrate observed all four different types cells examined. Chromatin immunoprecipitation assays showed...
Mesenchymal stem cells (MSCs) exhibit immunosuppressive efficacy and significantly inhibit the formation of atherosclerosis (AS) plaque in apolipoprotein E-knockout (apoE(-/-)) mice. Of note, largest lymphoid organ, skin, provides a readily accessible ideal source tissue for isolation MSCs: skin-derived MSCs (S-MSCs). However, effect mechanism therapeutic properties S-MSCs progression AS are unclear. We therefore investigated direct S-MSC treatment atherosclerotic apoE(-/-) Fifty mice were...