A5100700757- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diet, Metabolism, and Disease
- RNA modifications and cancer
- Barrier Structure and Function Studies
- Cancer Immunotherapy and Biomarkers
- Regulation of Appetite and Obesity
- Pediatric health and respiratory diseases
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Endoplasmic Reticulum Stress and Disease
- Stress Responses and Cortisol
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Gastric Cancer Management and Outcomes
RMIT University
2016-2025
Zhejiang Center for Disease Control and Prevention
2016-2025
Nantong University
2023-2025
Southwest Medical University
2025
Huazhong University of Science and Technology
2019-2024
Tongji Hospital
2023-2024
National Clinical Research Center for Digestive Diseases
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
State Key Laboratory of Cardiovascular Disease
2024
West China Hospital of Sichuan University
2014-2024
Alcohol abuse triggers neuroinflammation, leading to neuronal damage and further memory cognitive impairment. Few satisfactory advances have been made in the management of alcoholic central nervous Therefore, novel more practical treatment options are urgently needed. Butyrate, a crucial metabolite short-chain fatty acids (SCFAs), has increasingly demonstrated protect against numerous metabolic diseases. However, impact butyrate on chronic alcohol consumption-induced system (CNS) lesions...
This research aimed to identify novel indicators for sepsis by analyzing RNA sequencing data from peripheral blood samples obtained patients (n = 23) and healthy controls 10). 5148 differentially expressed genes were identified using the DESeq2 technique 5636 limma method(|Log2 Fold Change|≥2, FDR < 0.05). A total of 1793 immune-related ImmPort database, with 358 in both groups. Next, a Biological association network was constructed, five key hub (CD4, HLA-DOB, HLA-DRB1, HLA-DRA, AHNAK)...
Endoplasmic reticulum (ER) stress is suggested to cause hepatic insulin resistance by increasing de novo lipogenesis (DNL) and directly interfering with signaling through the activation of c-Jun N-terminal kinase (JNK) IκB (IKK) pathway. The current study interrogated these two proposed mechanisms in a mouse model induced high fructose (HFru) diet treatment fenofibrate (FB) 100 mg/kg/day, peroxisome proliferator-activated receptor α (PPARα) agonist known reduce lipid accumulation while...
Aim To explore antidiabetic medicine prescribing to women before, during and after pregnancy in different regions of Europe. Methods A common protocol was implemented across seven databases Denmark, Norway, The Netherlands, Italy (Emilia Romagna/Tuscany), Wales the rest UK. Women with a starting ending between 2004 2010, (Denmark, 2004–2009; 2005–2010; Emilia Romagna, 2008–2010), which ended live or stillbirth, were identified. Prescriptions for medicines issued (UK) dispensed (non-UK)...
// Li-Juan Wang 1 , Chen-Chen He Xin Sui Meng-Jiao Cai Cong-Ya Zhou Jin-Lu Ma Lei Wu 1,2 Hao Su-Xia Han and Qing Zhu Department of Oncology, the First Affiliated Hospital Medical School Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China 2 Center Radiotherapy, Provincial Tumor Hospital, Correspondence to: Zhu, email: Keywords : Intrahepatic cholangiocarcinoma, miR-21, PTPN14, PTEN, tumorigenesis Received November 07, 2014 Accepted January 20, 2015 Published February 28, Abstract...
Increasing evidence indicates that activated microglia play an important role in the inflammatory response following traumatic brain injury (TBI). Inhibiting M1 and stimulating M2 have demonstrated protective effects several animal models of central nervous system diseases. However, it is not clear whether polarization to attenuates axonal TBI. In this study, we used a lateral fluid percussion device induce mice. Mice were randomly assigned sham, TBI, TBI + rosiglitazone (peroxisome...
Abstract Background and Objective Asthma‐COPD overlap (ACO) is characterized by patients exhibiting features of both asthma COPD. Currently, there no specific treatment for ACO. This study aimed to investigate the therapeutic potential targeting CD131, a shared receptor subunit IL‐3, IL‐5 GM‐CSF, in ACO development preventing acute viral exacerbations. Methods A two‐hit mouse model was established house dust mite (HDM) allergen sensitization asthma, elastase emphysema. In separate model,...
High-carbohydrate (mainly fructose) consumption is a major dietary factor for hepatic insulin resistance, involving endoplasmic reticulum (ER) stress and lipid accumulation. Because autophagy has been implicated in ER stress, the present study investigated role of high-fructose (HFru) diet-induced resistance male C57BL/6J mice. The results show that chronic HFru feeding induced glucose intolerance impaired signaling transduction liver, associated with accumulation lipids. Intriguingly, was...
Abstract The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In present study, bioinformatical analysis transcriptomic data from oyster Crassostrea gigas and further biological validation revealed that TNF (CgTNF-1 CGI_10018786) could activate transcription factors NF-κB HSF (heat shock factor) through MAPK signaling pathway, then regulate apoptosis, redox reaction, neuro-regulation protein folding haemocytes....
Objectives To investigate the factors associated with age at natural menopause in a large population of Chinese adult women. Methods This cross-sectional study was part baseline survey China Kadoorie Biobank Zhejiang Province. A total 17,076 postmenopausal women were included present study. Relevant data socio-demographic, lifestyle, dietary and reproductive characteristics collected. Multinomial logistic regression models used to examine adjusted odds ratios (ORs) their 95% confidence...
Abstract Hepatocellular carcinoma (HCC) is the most common type of liver cancer with poor clinical outcomes. Long non-coding RNAs (lncRNAs) are extensively involved in tumorigenesis and progression HCC. However, more investigations should be carried out on novel lncRNAs their effects Here we identified a lncRNA KDM4A-AS1, which was aberrantly overexpressed HCC tissues, associated unfavorable features prognosis patients. KDM4A-AS1 promoted cell proliferation, migration, invasion vitro...
Background: In spinal cord injury (SCI), systemic inflammation and the death of nerve cells in are life threatening. The connection between gut microbiota signaling pathways has been a hot research topic recent years. Toll-like receptor 4/Myeloid differentiation factor 88 (TLR4/MyD88) pathway is closely related to inflammatory response. This study explored whether imbalance could affect TLR4/MyD88 regulate SCI provide new basis for treatment. Methods: An model was constructed influence on...
Abstract Background: HR+/HER2– mBC, the most common subset of breast cancer, is treated with sequential endocrine therapy + targeted agents followed by single-agent chemotherapy (CT), increasingly shorter benefit duration each subsequent treatment. High Trop-2 expression observed in cancer regardless subtype. SG a Trop-2-directed antibody-drug conjugate approved for pre-treated metastatic triple-negative cancer. In phase 3 TROPiCS-02 study, showed both significant progression-free survival...
Background and Purpose Matrine is a small molecule drug used in humans for the treatment of chronic viral infections tumours liver with little adverse effects. The present study investigated its therapeutic efficacy insulin resistance hepatic steatosis high‐fat‐fed mice. Experimental Approach C57BL / J 6 mice were fed chow or high‐fat diet 10 weeks then treated matrine metformin 4 weeks. effects on lipid metabolism glucose tolerance evaluated. Key Results Our results first showed that...
Formyl peptide receptor 2/lipoxin A4 (LXA4) (Fpr2/ALX) co-ordinates the transition from inflammation to resolution during acute infection by binding distinct ligands including serum amyloid A (SAA) and Resolvin D1 (RvD1). Here, we evaluated proresolving actions of aspirin-triggered RvD1 (AT-RvD1) in an coinfection pneumonia model. Coinfection with Streptococcus pneumoniae influenza virus (IAV) markedly increased pneumococcal lung load neutrophilic phase. Fpr2/ALX transcript levels were lungs...