A5029059009- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Pharmacological Effects of Natural Compounds
- Case Reports on Hematomas
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Bone fractures and treatments
- Management of metastatic bone disease
- Monoclonal and Polyclonal Antibodies Research
- Elbow and Forearm Trauma Treatment
- Acne and Rosacea Treatments and Effects
- Plant Toxicity and Pharmacological Properties
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Surgery and Rehabilitation
- Advanced Radiotherapy Techniques
- Pain Mechanisms and Treatments
- Alcohol Consumption and Health Effects
- Bone Tissue Engineering Materials
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- Gout, Hyperuricemia, Uric Acid
- Gut microbiota and health
- Stoma care and complications
- Cerebral Palsy and Movement Disorders
- Biochemical effects in animals
Huizhou Central People's Hospital
2012-2025
Third Affiliated Hospital of Southern Medical University
2023-2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2023-2024
Academy of Medical Sciences
2023-2024
Peking University
2016-2024
Peking University Cancer Hospital
2019-2024
Guangxi Medical University
2024
China Tobacco Guangxi Industrial (China)
2023
Guangdong Medical College
2020-2021
City Clinical Hospital
2021
Background: In spinal cord injury (SCI), systemic inflammation and the death of nerve cells in are life threatening. The connection between gut microbiota signaling pathways has been a hot research topic recent years. Toll-like receptor 4/Myeloid differentiation factor 88 (TLR4/MyD88) pathway is closely related to inflammatory response. This study explored whether imbalance could affect TLR4/MyD88 regulate SCI provide new basis for treatment. Methods: An model was constructed influence on...
Our group previously investigated the levels of anti-Gal and anti-nonGal IgM IgG in a cohort 75 healthy humans various backgrounds, found some significant differences related to factors such as age, gender, ABO blood group, diet, vaccination history, geographic location during childhood. We have now expanded our (n = 84) investigate anti-Neu5Gc anti-nonGal/nonNeu5Gc antibodies humans. Anti-nonGal human binding pRBCs pAECs from GTKO/CD46 GTKO/CD46/Neu5GcKO pigs were measured by flow...
Abstract Introduction Lung cancer is a common malignant tumor, and different types of immune cells may have effects on the occurrence development lung subtypes, including squamous cell carcinoma (LUSC) adenocarcinoma (LUAD). However, causal relationship between phenotype still unclear. Methods This study utilized comprehensive dataset containing 731 phenotypes from European Bioinformatics Institute (EBI) to evaluate potential LUSC LUAD using inverse variance weighted (IVW) method in...
The current optimization of implantable electrodes focuses on reducing impedance and improving anti-inflammatory properties. fabrication nanostructures electrode surfaces is a promising strategy for while also minimizing interference from the array immune cells that cause foreign body reactions. Electrochemical deposition common method creating nanostructures. However, generation impurities are difficult to remove during preparation process unavoidable. Herein, we develop simple, economical,...
Background: Spinal cord injury (SCI) damages the autonomic nervous system and affects homeostasis of gut microbiota. Ursolic acid (UA) is a candidate drug for treating due to its neuroprotective antioxidant functions. The purpose our study was investigate role UA on SCI mechanism. Methods: administered mice solvent corn oil used as control. weight recorded daily. Mice feces were collected 21 days after surgery 16S rRNA-amplicon sequencing untargeted metabolomics analysis. expressions NF-κB,...
The aim of the study was to compare effectiveness and safety solifenacin succinate tablets alone or combined with local estrogen for overactive bladder treatment in postmenopausal women.This multicenter, randomized, open, parallel-controlled clinical trial enrolled 104 women between January 2012 August 2013. Participants meeting inclusion criteria were randomized 1:1 12 weeks group A (solifenacin 5 mg qd + promestriene vaginal capsules intravaginally) B qd). Before after treatment, symptoms...
The fermentation medium of Micromonospora Y15 was optimized to enhance the production antimicrobial metabolites with activity tested against Listeria monocytogenes. First, optimal components (carbon source, nitrogen source and inorganic salt) were determined by single factor experiment. Second, Plackett–Burman experiment used screen significant factors. Third, steepest ascent undertaken figure out region Finally, central composite conducted optimize final components. results suggested that...
Background: Published data indicate that thyroid stimulating hormone receptor (TSHR) activities are associated with osteoporosis in some patients. Aim: This study aimed to elucidate whether a given polymorphism of the TSHR gene is osteoporosis. Materials and Methods: One hundred fifty subjects were recruited this study. The diagnosis was performed quantitative ultrasound system. examined by polymerase chain reaction-restriction fragment length polymorphism. Results: results showed nucleotide...
Intervertebral disc degeneration is the main cause of lumbago disease, in which extracellular matrix structure and moisture nucleus pulposus lost continuously. In this study, we aimed to detect differential expression silence mating type information regulation 2 homolog 1 (SIRT1) metalloproteinase-1 (MMP-1) human intervertebral cells explore effects SIRT1 MMP-1 on development degeneration. specimens from 41 patients who underwent lumbar protrusion resection at HuiZhou Municipal Central...
Abstract Background Osteoarthritis (OA), a refractory disease, is one of the leading contributors for disability worldwide. Since chondrocyte only resident cell in cartilage, this study aims to explore roles miR-129-3p and CPEB1 apoptosis knee joint fracture-induced OA. Methods Cartilage was collected from 20 OA patients who underwent total replacement (OA group) with contusion (normal group). Then, levels cartilage were quantified by qRT-PCR. Primary rat chondrocytes isolated identified...
The aim of this study was to explore the role hsa_circRNA_0000205 (circ_0000205) in chondrocyte injury osteoarthritis (OA) and underlying mechanism. Expression circ_0000205, microRNA (miR)-766-3p a disintegrin metalloproteinase with thrombospondin motif (ADAMTS)-5 detected by quantitative real time (qRT)-polymerase chain reaction (PCR) Western blot assays. Cell proliferation, apoptosis, extracellular matrix (ECM) synthesis were examined 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium...
Abstract The aim of this study was to evaluate the effects polymorphisms in excision repair cross-complementation group 1 (ERCC1) and alpha-fetoprotein (AFP) genes their haplotypes on susceptibility hepatocellular carcinoma (HCC), decipher association between single-nucleotide (SNPs) clinicopathologic characteristics HCC. Peripheral blood DNA extracted from 206 subjects. SNaPshot technique used for genotyping 5 SNP sites ERCC1 rs735482, rs1046282, rs3212948, AFP rs737241, rs4024 genotypes....
Rheumatic arthritis (RA) is an autoimmune disease with bad effects. Recent researches have shown that circular RNAs (circRNAs) could affect the progress of RA, but mechanism still indistinct. In this work, we explored roles circ_0025908 in RA.
Taurine up-regulated gene 1 (TUG1) is a cancer-associated long noncoding RNA (lncRNA) and engages in the development of spinal cord injury (SCI), suffering neuropathological disorder. However, regulatory role TUG1 acute SCI (ASCI) still underdetermined. RT-qPCR western blot analysis were applied to measure expression TUG1, microRNA-338 (miR-338), Bcl2-interacting killer (BIK), cleaved caspase 3 (c-caspase 3) hypoxia-inducible factor-1 alpha (HIF-1α) ASCI rats hypoxic cells. Cell death was...
The rate of failure internal fixation for femoral neck fractures has remained largely unchanged over the past 30 years. current study attempted to identify controllable variables influencing fractures.The included 190 patients aged from 20 65 with fracture caused by low energy violent injuries (fall standing height), who were treated multiple cannulated screws period 2005-2019 at a single centre. Kaplan-Meier (KM) survival analysis was firstly utilized evaluate potential interaction between...
Magnesium (Mg) is a promising biodegradable metal for orthopedic applications, and plasma electrolytic oxidation (PEO) has been widely studied as corrosion protection coating on Mg-based implants. However, the porous structures easily formed cracks in fluid are disadvantageous long-term protection. In this study, SiO2 layer was deposited PEO-treated Mg to inhibit formation of PEO prevent permeation corrosive fluid. The did not alter surface morphology but considerably enhanced its...
494 Background: Tumor mutation burden (TMB) has been established as a biomarker for response to immune therapy and prognosis in various cancers. However, the correlation between TMB microenvironment remains unwell studied, especially urothelial carcinoma. This study was aimed investigate relationship other immunotherapy related biomarkers, including genetic alterations, APOBEC signature, microsatellite instability (MSI), PD-L1 expression cell infiltration Methods: 131 patients with carcinoma...
To investigate perspectives and changes in treatment selection by Chinese surgeons since introduction of the watch-and-wait approach after neoadjuvant therapy for rectal cancer.