A5087781186- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Nutrition and Health in Aging
- Ultrasound in Clinical Applications
- Medical Imaging and Pathology Studies
- COVID-19 diagnosis using AI
- Respiratory Support and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Tuberculosis Research and Epidemiology
- Spine and Intervertebral Disc Pathology
- Cancer-related molecular mechanisms research
- Voice and Speech Disorders
- Radiomics and Machine Learning in Medical Imaging
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- MicroRNA in disease regulation
- Occupational and environmental lung diseases
- Peptidase Inhibition and Analysis
- Advanced X-ray and CT Imaging
- Sarcoidosis and Beryllium Toxicity Research
- Mycobacterium research and diagnosis
- Inflammasome and immune disorders
China-Japan Friendship Hospital
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
National Clinical Research Center for Digestive Diseases
2021-2024
Sun Yat-sen University
2014-2024
Academy of Medical Sciences
2023-2024
Capital Medical University
2021-2024
Third Affiliated Hospital of Sun Yat-sen University
2014-2024
National Clinical Research
2023-2024
Respiratory Clinical Trials
2024
Fu Wai Hospital
2023
Abstract Background Reduced exercise tolerance is an important clinical feature of chronic obstructive pulmonary disease (COPD) and associated with poor prognosis. The 6-min walk test (6MWT) widely used to assess capacity; however, it not commonly administered in primary medical institutions because requires a suitable site professional training. Ultrasound has great potential for evaluating skeletal muscle dimensions COPD. However, whether ultrasound can predict impaired unclear. Methods...
A comparative study of the five-repetition sit-to-stand test and 30-second to assess exercise tolerance in COPD patients Qin Zhang,1 Yan-xia Li,2 Xue-lian Li,3 Yan Yin,1 Rui-lan Li,1 Xin Qiao,1 Wei Hai-feng Ma,1 Wen-hui Yu-feng Han,1 Guang-qiao Zeng,4 Qiu-yue Wang,1 Jian Kang,1 Gang Hou1 1Institute Respiratory Disease, First Hospital China Medical University, Shenyang, China; 2Department Medicine, Dalian Dalian, 3Department Epidemiology, School Public Health, 4State Key Laboratory National...
Background and Objective: Anxiety/depression tuberculosis are global public health problems. The incidence of psychiatric morbidities is high among patients. However, little known about the prevalence anxiety depression Chinese pulmonary (PTB) patients, especially those with tracheobronchial (TBTB). goal present study was to explore associated factors depressive symptoms PTB patients without TBTB. Methods: A cross-sectional survey from three hospitals in Liaoning, China, conducted using a...
Peroxisome proliferator-activated receptor-gamma (PPARγ) is a ligand-activated transcription factor that exerts multiple biological effects. Growing evidence suggests PPARγ plays an important role in inflammation; however, the effects of this on inflammation caused by smoking are unclear.We measured expression inflammatory cytokines (leukotriene B4, LTB4 and interleukin 8, IL-8), toll-like receptors (TLR2 TLR4) alveolar macrophages (AMs) harvested from rats exposed to cigarette smoke (CS)...
Chronic obstructive pulmonary disease (COPD) is a complex and persistent lung lack of biomarkers. The aim this study to screen verify effective biomarkers for medical practice.Differential expressed genes analysis weighted co-expression network were used explore potential biomarker. Gene Ontology (GO) enrichment, Kyoto Encyclopedia Genes Genomes (KEGG) set enrichment (GSEA) mechanism. CIBERSORTx website was evaluate tissue-infiltrating immune cells. Enzyme-linked immunosorbent assay (ELISA)...
Purpose: Skeletal muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD) and associated a poor prognosis. Abnormal quantity of the lower limbs manifestation skeletal COPD. Shear wave ultrasound elastography (SWE) novel possible tool to evaluate qualitative parameters. This study explores feasibility SWE measure stiffness rectus femoris evaluates its value predicting sarcopenia Methods: Ultrasound examination was performed determine mean elasticity index...
Abstract Background Skeletal muscle dysfunction is an important co‐morbidity in patients with chronic obstructive pulmonary disease (COPD) and significantly associated increased mortality. Oxidative stress has been demonstrated trigger for COPD‐related skeletal dysfunction. Glycine‐histidine‐lysine (GHK) active tripeptide, which a normal component of human plasma, saliva, urine; promotes tissue regeneration; acts as anti‐inflammatory antioxidant properties. The purpose this study was to...
Oxidative stress and chronic inflammation play key roles in the pathogenesis of obstructive pulmonary disease (COPD). Astaxanthin (AXT) is a keto-carotenoid with variety biological functions, including antioxidant anti-inflammatory effects This study aimed to explore protective role underlying mechanism AXT COPD. In this study, we found alleviated emphysema CS-exposed mouse model regulated expression MMP-9/TIMP-1. And, attenuates CSE-induced small airway fibrosis. Meanwhile, inhibited...
Osteoarthritis (OA) is a chronic degenerative joint disorder in which genetic, hormonal, mechanical and ageing factors affect its progression. Current studies are focusing on chondrocytes as key mediator of OA at cellular level. however, the mechanism underlying chondrocyte apoptosis remains unclear. PUMA pro-apoptotic member BH3-only subgroup Bcl-2 family involved large number physiological pathological processes. In present study, we examined whether has role IL-1β-induced c-Jun N-terminal...
Mechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed investigate effects of high compression on NP and underlying molecular mechanism this process. Rat cells seeded in decalcified bone matrix were subjected non-compression (control) or (2% 20% deformation, 1.0 Hz, 6 hours/day). The reactive oxygen species (ROS) scavenger N-acetylcysteine (NAC) p38 MAPK inhibitor SB203580 used roles ROS...
Sarcopenia is common in patients with chronic obstructive pulmonary disease (COPD) and mainly caused by systemic inflammation. Resistin acts as a proinflammatory cytokine involved the activation of multiple inflammatory signaling pathways. The aim this study was to determine relationship between resistin levels inflammation assess clinical value circulating for sarcopenia COPD.
Silicosis is the most common type of pneumoconiosis, having a high incidence in workers chronically exposed to crystalline silica (CS). No specific medication exists for this condition. GHK, tripeptide naturally occurring human blood and urine, has antioxidant effects. We aimed investigate therapeutic effect GHK-Cu on silicosis its potential underlying molecular mechanism. An experimental mouse model was established observe effects lung inflammation fibrosis. Moreover, alveolar macrophages...