A5101828428- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Natural Antidiabetic Agents Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Diet and metabolism studies
- Rheumatoid Arthritis Research and Therapies
- Epigenetics and DNA Methylation
- Spondyloarthritis Studies and Treatments
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Bioactive natural compounds
- Regulation of Appetite and Obesity
- Liver Disease and Transplantation
- Psoriasis: Treatment and Pathogenesis
- Biochemical Acid Research Studies
- FOXO transcription factor regulation
- Fibroblast Growth Factor Research
- Muscle metabolism and nutrition
- Autophagy in Disease and Therapy
RMIT University
2012-2024
The First Affiliated Hospital, Sun Yat-sen University
2023
Sun Yat-sen University
2023
Wuyi University
2023
Wuyi University
2018-2022
Guangdong University of Technology
2019-2020
RMIT Europe
2015
High-carbohydrate (mainly fructose) consumption is a major dietary factor for hepatic insulin resistance, involving endoplasmic reticulum (ER) stress and lipid accumulation. Because autophagy has been implicated in ER stress, the present study investigated role of high-fructose (HFru) diet-induced resistance male C57BL/6J mice. The results show that chronic HFru feeding induced glucose intolerance impaired signaling transduction liver, associated with accumulation lipids. Intriguingly, was...
Background and Purpose Matrine is a small molecule drug used in humans for the treatment of chronic viral infections tumours liver with little adverse effects. The present study investigated its therapeutic efficacy insulin resistance hepatic steatosis high‐fat‐fed mice. Experimental Approach C57BL / J 6 mice were fed chow or high‐fat diet 10 weeks then treated matrine metformin 4 weeks. effects on lipid metabolism glucose tolerance evaluated. Key Results Our results first showed that...
The present study investigated the effects of matrine on non-alcoholic steatohepatitis (NASH) in mice induced by a methionine choline-deficient (MCD) diet and mechanism involved. was performed C57B/6J fed MCD for 6 weeks to induce NASH with or without treatment (100 mg/kg/day diet). Metformin used (250 diet) as comparator mechanistic investigation. Administration significantly reduced MCD-induced elevations plasma ALT AST but changing body liver fat content. Along alleviating injury,...
Our recent study (referred as Study 1) showed that the triterpenoid oleanolic acid (OA) was able to produce a sustained correction of hyperglycemia beyond treatment period in type 2 diabetes (T2D) mice with liver responsible site. To follow up previous observations, present 2) investigated possible role acetylation FoxO1 and associated events this therapeutic memory by characterizing pathways regulating status during post-OA treatments. OA (100 mg/kg/day for 4 weeks, treatment) reduced T2D...
Albiflorin (AF) is a small molecule (MW 481) isolated from Paeoniae radix, plant used as remedy for various conditions with pathogenesis shared by metabolic diseases. Reported here our characterization of its therapeutic profiles in three mouse models distinctive pathological features syndrome (MetS). Our results firstly showed that AF alleviated high fat (HF) induced obesity and associated glucose intolerance, suggesting efficacy MetS. In the type 2 diabetes (T2D) model combination HF low...
Consumption of diet rich in fat and cigarette smoking (CS) are independent risk factors non-alcoholic steatohepatitis (NASH), they often occur together some populations. The present study investigated the mechanisms high-fat (HFD) CS, individually combination, on pathogenesis NASH mice. C57BL/6 male mice were subjected to either a low-fat chow (CH) or HFD with without mainstream CS-exposure (4 cigarettes/day, 5 days/ week for 14 weeks). alone caused hepatosteatosis (2.5-fold increase TG...
Background SOX17 has been identified as a critical factor in specification of human primordial germ cells, but whether regulates development cells after sex differentiation is poorly understood. Methods We collected specimens gonadal ridge from an embryo (n=1), and ovaries foetuses (n=23) adults (n=3). Germ were labelled with SOX17, VASA (classic marker), phosphohistone H3 (PHH3, mitosis marker) synaptonemal complex protein 3 (SCP3, meiosis marker). Results was detected both cytoplasm...
Diets(饮食) rich in fat are a major(主要) cause(原因) of metabolic disease(疾病), and nutritional(营养) food has been widely(广泛) used(使用) to counteract the disorders such(这样) as obesity(肥胖) fatty(脂肪) liver(肝). The present study investigated effects oleuropein-enriched extract(提取物) from Jasminum grandiflorum L. flowers (OLE-JGF) high-fat diet(饮食) (HFD)-fed mice oleic acid(酸) (OA)-treated AML-12 cells. Treatment(治疗) HFD-fed with 0.6% OLE-JGF for 8 weeks significantly reduced body liver(肝) weights, well...
Abstract Cigarette smoking (CS) is known to reduce body weight and this often masks its real effect on insulin action. The present study tested the hypothesis that CS can divert lipid deposition muscles offset supposed benefit of reduced gain signalling in major site for glucose tolerance (or action). was conducted mice exposed chronic followed by either a chow (CH) diet or high-fat (HF) diet. increased triglyceride (TG) levels both plasma muscle despite adiposity. led intolerance CH-fed...
Postnatal overconsumption of fat is believed to increase the susceptibility metabolic disease in later life. Here we examined whether prior exposure high (HF) adulthood may also accelerate development disorders mice. Adult mice (12 weeks) were pre-exposed two episodes an HF diet each for 2 weeks followed by washout with a low-fat diet. The then fed same 6 weeks. Unexpectedly, exposures significantly alleviated body weight gain, visceral adiposity and glucose/insulin intolerance during period...