A5050773090- Congenital Anomalies and Fetal Surgery
- Prenatal Screening and Diagnostics
- Pregnancy and Medication Impact
- Cleft Lip and Palate Research
- Folate and B Vitamins Research
- Urological Disorders and Treatments
- Congenital Heart Disease Studies
- Pregnancy and preeclampsia studies
- Congenital Diaphragmatic Hernia Studies
- Health, Environment, Cognitive Aging
- Tracheal and airway disorders
- Pharmacological Effects and Toxicity Studies
- Esophageal and GI Pathology
- Craniofacial Disorders and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Health
- Cardiovascular Issues in Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Genomics and Rare Diseases
- Gestational Diabetes Research and Management
- Fetal and Pediatric Neurological Disorders
- Neonatal Respiratory Health Research
- Urinary and Genital Oncology Studies
- Environmental Justice and Health Disparities
- Congenital heart defects research
Istituto di Fisiologia Clinica
2016-2025
National Research Council
2016-2025
Fondazione Toscana Gabriele Monasterio
2014-2024
Regione Toscana
2011-2024
Indianapolis Zoo
2023
Triangle
2023
Committee on Publication Ethics
2023
University of Groningen
2016-2023
University Medical Center Groningen
2018-2023
Otto-von-Guericke University Magdeburg
2018-2023
Objectives To assess international trends and patterns of prenatal diagnosis critical congenital heart defects (CCHDs) their relation to total live birth CCHD prevalence mortality. Setting Fifteen defect surveillance programmes that participate in the International Clearinghouse for Birth Defects Surveillance Research from 12 countries Europe, North South America Asia. Participants Live births, stillbirths elective terminations pregnancy fetal anomaly diagnosed with 1 selected CCHD,...
Abstract Objectives To assess at a population‐based level the frequency with which severe structural congenital malformations are detected prenatally in Europe and gestational age detection, to describe regional variation these indicators. Methods In period 1995–1999, data were obtained from 17 European registries of (EUROCAT). Included all live births, fetal deaths terminations pregnancy diagnosed one or more following malformations: anencephalus, encephalocele, spina bifida, hydrocephalus,...
We studied 5,449 cases of cleft lip (CL) with or without palate (CL/P) identified between 1980 and 2000 from the EUROCAT network 23 registers (nearly 6 million births) in 14 European countries. investigated specific types defects associated clefts. Among CL/P (prevalence = 9.1 per 10,000), 1,996 (36.6%) affected only 3,453 (63.4%) involved CL (CLP). A total 3,860 (70.8%) occurred as isolated anomalies 1,589 (29.2%) were other such multiple congenital unknown origin (970), chromosomal (455)...
Abstract BACKGROUND: The aim of this study was to examine trends Down syndrome (DS) in relation maternal age and termination pregnancies (ToP) 20 registries the International Clearinghouse for Birth Defects Surveillance Research (ICBDSR). METHODS: Trends births with DS (live‐born stillborn), ToP DS, (percentage mothers older than 35 years) were examined by year over a 12‐year period (1993–2004). total mean number covered 1550,000 annually. RESULTS: percentage years increased from 10.9% 1993...
Background Surveillance of congenital anomalies is important to identify potential teratogens. Methods This study analysed the prevalence 61 anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980–2012). Live births, fetal deaths and terminations pregnancy for were with multilevel random-effects Poisson regression models. Results Seventeen had statistically significant trends from 2003–2012; 12 increasing 5 decreasing. Conclusions The annual severe heart...
<h3>Abstract</h3> <h3>Objective</h3> To investigate whether exposure to metformin during the first trimester of pregnancy, for diabetes or other indications, increases risk all specific congenital anomalies. <h3>Design</h3> Population based exploratory case-control study using malformed controls. Cases 29 subgroups non-genetic anomalies, and anomalies combined, were compared with controls (all genetic syndromes). <h3>Setting</h3> 11 EUROmediCAT European anomaly registries surveying 1 892 482...
Hypospadias is a common congenital malformation. The prevalence of hypospadias has large geographical variation, and recent studies have reported both increasing decreasing temporal trends. It unclear whether associated with maternal age. To analyze the trends total hypospadias, isolated multiple anomalies, known cause, severity subtypes in Europe over 10-year period to investigate age hypospadias. We included all children born from 2001 2010 who were registered 23 EUROCAT registries....
Maternal pregestational diabetes is a well-known risk factor for congenital anomalies. This study analyses the spectrum of anomalies associated with maternal using data from large European database population-based surveillance anomalies.Data 18 EUROCAT registries in 1990-2005. All malformed cases occurring to mothers (diabetes cases) were compared all same registry areas without (non-diabetes cases).There 669 and 92,976 non cases. Odds ratios pregnancies relative non-diabetes comparing each...
Objective To explore the prescribing patterns of selective serotonin reuptake inhibitors ( SSRI s) before, during and after pregnancy in six European population‐based databases. Design Descriptive drug utilisation study. Setting Six electronic healthcare databases Denmark, Netherlands, Italy (Emilia Romagna/Tuscany), Wales rest UK . Population All women with a ending live or stillbirth starting between 2004 2010. Methods A common protocol was implemented across to identify prescriptions...
Aim To explore antidiabetic medicine prescribing to women before, during and after pregnancy in different regions of Europe. Methods A common protocol was implemented across seven databases Denmark, Norway, The Netherlands, Italy (Emilia Romagna/Tuscany), Wales the rest UK. Women with a starting ending between 2004 2010, (Denmark, 2004–2009; 2005–2010; Emilia Romagna, 2008–2010), which ended live or stillbirth, were identified. Prescriptions for medicines issued (UK) dispensed (non-UK)...
Abstract The aim of the study is to determine prevalence, outcomes, and survival (among live births [LB]), in pregnancies diagnosed with trisomy 13 (T13) 18 (T18), by congenital anomaly register region. Twenty‐four population‐ hospital‐based birth defects surveillance registers from countries, contributed data on T13 T18 between 1974 2014 using a common data‐reporting protocol. mean total prevalence (i.e., LB, stillbirths, elective termination pregnancy for fetal anomalies [ETOPFA]) ETOPFA (...
ABSTRACT Background In Europe, the prevalence of congenital ocular anomaly (COA) is estimated at 3.7 per 10,000 births. While certain COAs have a genetic origin, cause for most patients remains unknown. The role medications administered during pregnancy in COA genesis humans unclear. Objective To investigate any association between fetal exposure first trimester to and occurrence COA. Methods We conducted case‐malformed‐control study using data on 298,351 cases registered as having anomalies...
The aim of this study was to examine the prevalence trisomies 18 and 13 in Europe associated anomalies. Twenty‐five population‐based registries 16 European countries provided data from 2000–2011. Cases included live births, fetal deaths (20+ weeks’ gestation), terminations pregnancy for anomaly (TOPFAs). anomalies reported births. trisomy were 4.8 (95%CI: 4.7–5.0) 1.9 1.8–2.0) per 10,000 total Seventy three percent cases with or resulted a TOPFA. Amongst 468 born babies 18, 80% (76–83%) had...
<b>Objectives</b> To provide contemporary estimates of the prevalence microcephaly in Europe, determine if diagnosis is consistent across and evaluate whether changes would be detected using current European surveillance performed by EUROCAT (the Surveillance Congenital Anomalies). <b>Design</b> Questionnaire population based observational study. <b>Setting</b> 24 registries covering 570 000 births annually 15 countries. <b>Participants</b> Cases not associated with a...
BackgroundPregnant women with asthma need to take medication during pregnancy.ObjectiveWe sought identify whether there is an increased risk of specific congenital anomalies after exposure antiasthma in the first trimester pregnancy.MethodsWe performed a population-based case-malformed control study testing signals identified literature review. Odds ratios (ORs) main groups were calculated for each 10 signal compared registrations nonchromosomal, nonsignal as registrations. In addition,...