A5006706706- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Cancer Risks and Factors
- Pregnancy and preeclampsia studies
- Pharmaceutical studies and practices
- Pharmacological Effects and Toxicity Studies
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Intestinal Malrotation and Obstruction Disorders
- Influenza Virus Research Studies
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Pharmacovigilance and Adverse Drug Reactions
- Healthcare Systems and Practices
- Neonatal Respiratory Health Research
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Prenatal Substance Exposure Effects
- Management of metastatic bone disease
- Reproductive Health and Contraception
- Pediatric Urology and Nephrology Studies
- HIV-related health complications and treatments
- Foreign Body Medical Cases
Pharmacochimie et Pharmacologie pour le Développement
2016-2025
Inserm
2014-2025
Université Toulouse III - Paul Sabatier
2015-2025
Université de Toulouse
2014-2025
Sciences, Philosophie, Histoire
2021-2025
Centre Hospitalier Universitaire de Toulouse
2015-2024
Centre de recherche en Epidémiologie et Santé des Populations
2024
Laboratoire CarMeN
2022-2023
Hospices Civils de Lyon
2022-2023
Université Claude Bernard Lyon 1
2022-2023
ABSTRACT Background In Europe, the prevalence of congenital ocular anomaly (COA) is estimated at 3.7 per 10,000 births. While certain COAs have a genetic origin, cause for most patients remains unknown. The role medications administered during pregnancy in COA genesis humans unclear. Objective To investigate any association between fetal exposure first trimester to and occurrence COA. Methods We conducted case‐malformed‐control study using data on 298,351 cases registered as having anomalies...
In 2019, the Innovative Medicines Initiative (IMI) funded ConcePTION project—Building an ecosystem for better monitoring and communicating safety of medicines use in pregnancy breastfeeding: validated regulatory endorsed workflows fast, optimised evidence generation—with vision that there is a societal obligation to rapidly reduce uncertainty about medication breastfeeding. The present paper introduces set concepts used describe European data sources involved project illustrates Common Data...
Purpose Randomized, controlled trials showed that screening reduces breast cancer mortality rates, but some recent observational studies have concluded programmatic has had minor effect on rates. This apparent contradiction might be explained by the use of aggregated data in studies. We assessed long-term using individual-level data. Materials and Methods Using from mammography Copenhagen Danish national registers, we compared observed rate women invited to with expected absence screening....
We presented an adjustment method for the calculation of medication exposure trajectories based on number dispensed packs and type dispensations (occasional or regular). A comparative study EFEMERIS data was carried out using three different scenarios trajectory depending whether not periodicity were taken into account. The impact scenario highlighted global indicators Define-Daily Dose (DDD) all women exposed; changes in individual from one to another out; we also compared results a...
Abstract Purpose Antiretroviral drugs are recommended during pregnancy to achieve HIV viral suppression and reduce mother-to-child transmission. Congenital anomaly signals were reported after fetal exposure antiretroviral in several studies warranting further investigation. We aimed evaluate the risk of congenital anomalies using European registry data. Methods A case/non-case study was performed, EUROmediCAT central database. All anomalies, exposed any drugs, included from 1995 2019....
<b>Objective</b> To evaluate the possible effects of exposure to neuraminidase inhibitors during embryo-fetal life with respect adverse neonatal outcomes and congenital malformations. <b>Design</b> Population based multinational observational cohort study meta-analysis. <b>Setting</b> National registers covering information on maternal healthcare, births, prescriptions in Denmark, Norway, Sweden EFEMERIS database from Haute-Garonne district France. <b>Participants</b> All...
Objective: Asthma affects between 3% to 8% of pregnant women. Previous studies have suggested that women's prescriptions for asthma medications change during pregnancy. The aim was describe the prescription before and pregnancy in France. Methods: Women from EFEMERIS, a French database assessing drugs prescribed, dispensed reimbursed pregnancy, delivering July 2004 December 2012, were included. Women, who on at least two dates 3 months prior through delivery, considered. Results: 2,977 women...
Abstract Overdiagnosis is a harmful consequence of screening which particularly challenging to estimate. An unbiased setting measure overdiagnosis in breast cancer requires comparative data from screened and an unscreened cohort for at least 30 years. Such randomised will not become available, leaving us with observational over shorter time periods outcomes modelling. This collaborative effort the International Cancer Screening Network quantified variation estimated organised programmes...
Objective To compare pregnancy outcome between women exposed and unexposed to oseltamivir during pregnancy. Design A comparative observational cohort study of Setting French prescription database ( EFEMERIS ) that includes data for pregnant was used. records prescribed dispensed reimbursed drugs outcomes in Haute‐Garonne, South West France. Population Women who delivered from 1 July 2004 31 December 2010. Methods The compared women. Two were individually matched, by maternal age, month, year...
Abstract Purpose The aim of this study was to develop a new pharmacoepidemiological method take into account intensity and evolution drug exposure, applied pregnant women. Methods Pregnant women were classified according their in three steps: Conversion prescription data exposure variables (using ATC‐DDD) Construction individual trajectories Clustering the R package Kml ) We psychotropic drugs prescribed during pregnancy. present involved women, included EFEMERIS database, who gave birth...
There are few published data about possible effects of veinotonics in pregnant women. The present study investigates potential adverse drug reactions pregnancy.EFEMERIS is a database including prescribed and dispensed reimbursed drugs during pregnancy (data from Caisse Primaire d'Assurance Maladie) outcomes Maternal Infant Protection Service Antenatal diagnostic Centre). Women who delivered 1 July 2004 to December 2007 Haute-Garonne were registered the French Health Insurance have been...
Abstract Purpose The aim of this study was to examine the potential benefit take into account duration and intensity drug exposure using recently published method based on individual trajectories. This approach used define profiles anxiolytics/hypnotics during pregnancy evaluate effect newborn health. Methods performed in EFEMERIS database (54 918 mother–children pairs). An estimation adaptation extrauterine life assessed several criteria especially cardio‐respiratory symptoms. A proxy...
The primary aim of breast cancer screening is to reduce mortality, but also has negative side-effects as overdiagnosis. To evaluate a programme, both benefits and harms should be considered. Published estimates the benefit-to-harm ratio, number deaths prevented divided by overdiagnosed cases, varied considerably. objective study was estimate ratio in Denmark. numbers cases [invasive ductal carcinoma situ (DCIS)] were estimated per 1,000 women aged 50-79, using national published for...
Aim The aim of this study was to evaluate the potential effect in utero exposure drugs with atropinic properties on infant psychological development using burden (AB) scales. Methods Women from EFEMERIS cohort, a French database including prescribed and dispensed reimbursed during pregnancy outcomes, delivering between 2004 2010 were included ( n = 43 740). Each drug classified as having no (score 0), few 1) or strong 3) properties. AB per woman calculated by adding scores pregnancy....
Abstract Background Although breast cancer screening reduces mortality at the population level, subgroups of women may benefit differently. We investigated impact health status on effect screening. Methods The study included 181 299 invited in two population‐based programs Denmark and 1 526 446 control subjects, followed from April 1981 to December 2014. Poisson regressions were used compare observed rate with expected absence among without chronic diseases. Chronic diseases defined as any...
Abstract Introduction Service breast cancer screening is difficult to evaluate because there no unscreened control group. Due a natural experiment, where 20% of women were offered in two regions up 17 years before other women, Denmark unique position. We utilized this opportunity assess outcome service screening. Materials and methods Screening was Copenhagen from 1991 Funen 1993 aged 50–69 years. used difference-in-differences methodology with study group screening; historical group;...
( BMJ . 2017;356:j629) Pregnant women are at increased risk of serious adverse effects from influenza. As a result, government agencies in the United States and Europe recommend neuraminidase inhibitors for treatment parturients with influenza as well prophylaxis pregnant exposed to virus. However, safety these drugs fetus has not been established. result 2009 H1N1 pandemic there was large increase number inhibitors. While previous observational studies have found any connection between...
The purpose of breast cancer screening is to reduce mortality. In order achieve this purpose, an X-ray search—a mammography examination—is made the tissue healthy women detect potential cancers that have not given rise symptoms. With early detection, a woman with can be offered more efficient treatment than it would otherwise had been possible. If works, screen-detected will better prognosis diagnosed symptoms cancer.