A5108058498- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Advanced Vision and Imaging
- Advanced Image and Video Retrieval Techniques
- Video Surveillance and Tracking Methods
- Robotics and Sensor-Based Localization
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Advanced Measurement and Detection Methods
- RNA modifications and cancer
- Quinazolinone synthesis and applications
- Infrared Target Detection Methodologies
- Synthesis and biological activity
- Genetic factors in colorectal cancer
- Cancer therapeutics and mechanisms
- Gastrointestinal Tumor Research and Treatment
- Image Retrieval and Classification Techniques
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
Shenyang Institute of Automation
2016-2025
Chinese Academy of Sciences
2010-2025
China Medical University
2016-2025
First Hospital of China Medical University
2016-2025
Changsha Medical University
1993-2025
Northwestern Polytechnical University
2024-2025
University of Tsukuba
2025
Institute of High Energy Physics
2024-2025
Xi'an Jiaotong University
2013-2024
Air Force Medical University
2023-2024
Purpose There is currently no standard treatment strategy for patients with advanced metastatic gastric cancer experiencing progression after two or more lines of chemotherapy. We assessed the efficacy and safety apatinib, a novel vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor, in gastroesophageal junction adenocarcinoma whom at least prior chemotherapy had failed. Patients Methods This was randomized, double-blind, placebo-controlled phase III trial. from 32 centers...
Purpose: The third-generation EGFR tyrosine kinase inhibitor osimertinib is approved to treat patients with T790M-positive non-small cell lung cancer (NSCLC) who have developed resistance earlier-generation drugs. Acquired C797S mutation has been reported mediate in some patients. However, the remaining mechanisms are largely unknown.Experimental Design: We performed profiling using targeted next-generation sequencing (NGS) for 416 cancer-relevant genes on 93 osimertinib-resistant patients'...
Practical applications of lithium-sulfur batteries are simultaneously hindered by two serious problems occurring separately in both electrodes, namely, the shuttle effects lithium polysulfides and uncontrollable growth dendrites. Herein, to explore a facile integrated approach tackle as well guarantee efficient charge transfer, we used two-dimension hexagonal VS2 flakes building blocks assemble nanotowers on separators, forming symmetrical double-side-modified polypropylene separator without...
The CHOICE-01 study investigated the efficacy and safety of toripalimab in combination with chemotherapy as a first-line treatment for advanced non-small-cell lung cancer (NSCLC).Patients (N = 465) treatment-naive, NSCLC without EGFR/ALK mutations were randomly assigned 2:1 to receive 240 mg (n 309) or placebo 156) once every 3 weeks 4-6 cycles, followed by maintenance plus standard care. Stratification factors included programmed death ligand-1 expression status, histology, smoking status....
Background and AimsArtificial intelligence (AI)–assisted colonoscopy improves polyp detection characterization in colonoscopy. However, data from large-scale multicenter randomized controlled trials (RCT) an asymptomatic population are lacking.MethodsThis RCT aimed to compare AI-assisted with conventional for adenoma population. Asymptomatic subjects 45–75 years of age undergoing colorectal cancer screening by direct or fecal immunochemical test were recruited 6 referral centers Hong Kong,...
J o u r n a l P e -p f patients in the iruplinalkib group (median PFS, 27.7 months [95% CI, crizotinib group; HR, 0.34 [98.02% 0.23-0.52];p<0.0001).The ORR assessed by IRC was 93.0% (95% 87.5-96.6) and 89.3% 83.1-93.7) group.The intracranial 90.9% (10/11, 95% 58.7-99.8) 60.0% (9/15, 32.3-83.7) for with measurable baseline CNS metastases.Incidence of grade 3 or 4 treatment-related adverse events 51.7% 49.7% group.Interpretation: Iruplinalkib demonstrated significantly improved PFS antitumor...
Epidermal growth factor receptor (EGFR) mutations are the strongest response predictors to EGFR tyrosine kinase inhibitors (TKI) therapy, but knowledge of mutation frequency on lung adenocarcinoma is still limited retrospective studies. The PIONEER study (NCT01185314) a prospective molecular epidemiology in Asian patients with newly diagnosed advanced adenocarcinoma, aiming prospectively analyze status IIIB/IV treatment-naïve adenocarcinomas Asia. We report mainland China subset results....
The incipient features in the vibration signal are a typical signature of rolling bearing faults, and their extraction is vital for early-stage fault diagnosis, yet quite challenging given complexity noisy signal. Therefore, weighted frequency domain energy operator (FDEO) spectral method based on soft thresholding fast iterative filtering (FIF) proposed this work. Firstly, FIF technique to improve equivalent filter properties such as continuity transition band lengths. Secondly, an...
Time series prediction problems can play an important role in many areas, and multi-step ahead time forecast, like river flow stock price could help people to make right decisions. Many predictive models do not work very well predictions. LSTM (Long Short-Term Memory) is iterative structure the hidden layer of recurrent neural network which capture long-term dependency series. In this paper, we try model different types data patterns, use RNN for prediction, compare result with other...