A5100630787- Immune Response and Inflammation
- Oral microbiology and periodontitis research
- Immune cells in cancer
- Gastrointestinal motility and disorders
- Glioma Diagnosis and Treatment
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protease and Inhibitor Mechanisms
- Invertebrate Immune Response Mechanisms
- Endometriosis Research and Treatment
- Infant Health and Development
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Vagus Nerve Stimulation Research
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Nanoplatforms for cancer theranostics
- Hedgehog Signaling Pathway Studies
- Ginseng Biological Effects and Applications
- Arsenic contamination and mitigation
- Asthma and respiratory diseases
Nanjing Medical University
2015-2025
Second Affiliated Hospital of Dalian Medical University
2024-2025
Dalian Medical University
2024-2025
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
Shanghai Jiao Tong University
2007-2024
Second Affiliated Hospital of Harbin Medical University
2014-2024
Harbin Medical University
2013-2024
Jiangsu Province Hospital
2014-2024
Command Hospital
2024
Abstract Alternatively activated macrophages (AAM) play a crucial role in type 2 immunity. Mice deficient ST2, receptor for the latest member of IL-1 family, IL-33, have impaired immune responses. We therefore reasoned that IL-33/ST2 signaling may be involved differentiation and activation AAM during airway inflammation. report here IL-33 changed quiescent phenotype alveolar toward an expressed mannose receptor, IL-4Rα, produced high levels CCL24 CCL17 IL-13-dependent manner IL-33-induced...
Periodontitis is a bacterially induced chronic inflammatory disease. Toll-like receptors (TLRs), which could recognize microbial pathogens, are important components in the innate and adaptive immune systems. Both qualitatively quantitatively distinct responses might result from different bacteria stimulation triggering of TLRs. This study explores interaction Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans (previously...
The host immune response affects pathogen virulence in Clostridium difficile infection (CDI). Thus, cytokine responses to CDI likely are associated with disease initiation and progression. Understanding the molecular drivers of inflammation biochemical markers severity is important for developing novel therapies predicting prognosis. In this study, we investigated production patients evaluated potential cytokines serve as biomarkers predictors severity. systemic profiles 36 (20 severe...
Using inducible nitric oxide (NO) synthase (iNOS) knockout mice (iNOS-/-), we tested the hypotheses that 1) lack of iNOS attenuates cardiac remodeling and dysfunction improves reserve postmyocardial infarction (MI), an effect is partially mediated by reduction oxidative stress due to reduced interaction between NO reactive oxygen species (ROS); 2) cardioprotection afforded deletion eliminated Nomega-nitro-L-arginine methyl ester (L-NAME) inhibition endothelial NOS (eNOS) neuronal (nNOS). MI...
Zhao L. Zhou Y, Xu Sun Li L, Chen W. Effect of non-surgical periodontal therapy on the levels Th17/Th1/Th2 cytokines and their transcription factors in Chinese chronic periodontitis patients. J Clin Periodontol 2011; doi: 10.1111/j.1600-051X.2011.01712.x. Abstract Aim: A new subset CD4+ T cells, Th17, has been recently discovered independent from Th1/Th2 paradigm. The aim this study was to investigate effects expression factors, Th17 cell vibration Materials methods: (IL-17,...
Summary Aims Mcl‐1, an antiapoptotic member of the Bcl‐2 family, is overexpressed in human glioblastoma, conferring a survival advantage to tumor cells. The mechanisms underlying its dysregulation have not been clarified. In this study, we explored involvement micro‐RNAs that acted as endogenous sequence‐specific suppressors gene expression. Methods and results Using computational TCGA analysis, identified miR‐139 being downregulated glioblastoma comparison with brain tissue, well possessing...
Interleukin-17 (IL-17 or IL-17A), a pleiotropic cytokine produced by T helper (Th) 17 cells, is involved in the pathogenesis of various autoimmune and inflammatory disorders, including periodontitis. Although ability pro-inflammation periodontitis have been widely investigated, other biological functions IL-17, its role bone remodeling underlying molecular mechanism, not well clarified. In present study, IL-17 could significantly enhance expression receptor activator for nuclear factor-κB...
Few studies have associated microRNAs (miRNAs) with the hedgehog (Hh) pathway. Here, we investigated whether targeting smoothened (SMO) miR-326 would affect glioma biological behavior and stemness. To investigate expression of SMO in specimens cell lines, utilized quantitative real-time (qRT)-PCR, Western blot, immunohistochemistry, fluorescence situ hybridization. The luciferase reporter assay was used to verify relationship between miR-326. We performed counting kit-8, transwell, flow...
The aim of this study was to investigate the effect downregulating Hedgehog pathway by GANT61 on human glioma cells, examine consequent changes temozolomide (TMZ)-induced effects and explore molecular mechanisms.The cytotoxicity a Gli1/2 inhibitor, examined both alone in combination with TMZ cell lines. mRNA protein expression alterations were determined quantitative real-time polymerase chain reaction (qRT-PCR) Western blot, respectively. CCK-8 assay detected proliferative capability....
Abstract The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In present study, bioinformatical analysis transcriptomic data from oyster Crassostrea gigas and further biological validation revealed that TNF (CgTNF-1 CGI_10018786) could activate transcription factors NF-κB HSF (heat shock factor) through MAPK signaling pathway, then regulate apoptosis, redox reaction, neuro-regulation protein folding haemocytes....
Glioblastoma multiform (GBM) is the most common malignant primary brain tumor in adults. Radiotherapy plus concomitant and adjuvant TMZ chemotherapy current standard of care for patients with GBM. Matrix metalloproteinases (MMPs), a family zinc-dependent endopeptidases, are key modulators invasion metastasis due to their ECM degradation capacity. The aim present study was identify informative MMP member terms prognostic predictive ability GBM.The mRNA expression profiles all genes were...
Background/Aims: The gut-vascular barrier (GVB) has recently been depicted to dampen the bacterial invasion of bloodstream. intestinal mucosa is a tissue rich in small vessels including capillaries. In this study, protective effect berberine on GVB bowel was investigated. Methods: rat cecal ligation and puncture (CLP) sepsis model employed evaluate serum endotoxin level vascular permeability Evans blue vivo. microvascular endothelial cells (RIMECs) treated by lipopolysaccharide (LPS) were...
Mitochondrial abnormality has been shown in many kidney disease models. However, its role the pathogenesis of chronic diseases (CKDs) is still uncertain. In present study, a mitochondrial complex I inhibitor rotenone was applied to mice subjected unilateral ureteral obstruction (UUO). Following 7-days treatment, remarkable attenuation tubular injury detected by PAS staining. line with improvement morphology, remarkably blunted fibrotic response as downregulation fibronectin (FN), plasminogen...
Abstract Periodontal biotype is used to describe the morphological characteristics of periodontal tissues and closely related health prognosis many dental treatments. This study was undertaken explore distribution in a young Chinese population evaluate accuracy different methods for gingival thickness (GT) measurement. A total 372 teeth from 31 periodontally healthy subjects were included. GT measured simultaneously by probe transparency, transgingival probing cone-beam computed tomography...
β-elemene, extracted from herb medicine Curcuma wenyujin has potent anti-tumor effects in various cancer cell lines. However, the activity of β-elemene against glioma cells remains unclear. In present study, we assessed on human and explored underlying mechanism.Human U87 were used. Cell proliferation was determined with MTT assay colony formation to detect effect at different doses times. Fluorescence microscopy used observe apoptosis Hoechst 33258 staining change cycling analyzed by flow...
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Lung cancer is one of the more common malignant tumors posing a great threat to human life, and it very urgent find safe effective therapeutic drugs. The antitumor effect ginsenosides has been reported be treatment with strong high safety profile. This paper aimed investigate inhibitory ginsenoside Rb1 on 95D NCI-H460 lung cells its pathway promote apoptosis. We performed CCK-8 assay, fluorescence staining flow cytometry, scratch healing Transwell assay detect effects different...
This study aimed to observe the effects of initial periodontal therapy on level neutrophil extracellular traps (NETs) in gingival crevicular fluid (GCF) patients with severe periodontitis and analyze factors related formation NETs. Thirty-one stage Ⅲ-Ⅳ were recruited. Clinical parameters, including plaque index (PLI), (GI), probing depth (PD), clinical atta-chment loss (CAL), recorded before 6-8 weeks after therapy. Levels NETs GCF detected by immunofluorescence staining. Quantities total...
Hepatocellular carcinoma (HCC) early identification is crucial for improving patient outcomes. Current screening methods are often complex and costly. This study developed a simplified, cost-effective HCC model using serum marker data. A diverse population from two Chinese hospitals was recruited, including cancer patients, hospital healthy individuals. two-stage created: LASSO logistic regression preliminary screening, followed by incorporating alpha-fetoprotein (AFP). The model's...