A5024669370- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Radiation Dose and Imaging
- Musculoskeletal pain and rehabilitation
- Gastrointestinal motility and disorders
- Anesthesia and Pain Management
- Radioactive contamination and transfer
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Graphite, nuclear technology, radiation studies
- Pediatric Pain Management Techniques
- Nuclear and radioactivity studies
- Pain Management and Placebo Effect
- Dermatology and Skin Diseases
- Advanced Radiotherapy Techniques
- Menopause: Health Impacts and Treatments
- Stress Responses and Cortisol
- Myofascial pain diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Ion channel regulation and function
- Diet and metabolism studies
- Radiation Detection and Scintillator Technologies
- Menstrual Health and Disorders
- Radioactivity and Radon Measurements
- Acupuncture Treatment Research Studies
- Advanced X-ray and CT Imaging
University of Maryland, Baltimore
2015-2024
Seattle University
2022
Christie's
2011
Pacific Northwest National Laboratory
1988-2010
University of Baltimore
2007
Battelle
2001-2004
Washington State University
2003
Society for Neuroscience
2003
Institute of Neurobiology
2002
United States Department of Commerce
1988-2001
In September 2006, members of the Sex, Gender and Pain Special Interest Group International Association for Study met to discuss following: (1) what is known about sex gender differences in pain analgesia; (2) are “best practice” guidelines research with respect gender; (3) crucial questions address near future? The resulting consensus presented herein includes input from basic science, clinical psychosocial researchers, as well recognized experts sexual differentiation reproductive...
The rat lumbosacral spinal cord was immunocytochemically stained for Fos-like immunoreactivity following repetitive colorectal distention (CRD) to 20, 40 or 80 mm Hg. Following all 3 pressures, immunoreactive (Fos-ir) nuclei were observed primarily in laminae I-II, V-VII and X, although some labeled III-IV. Eighty Hg CRD resulted significantly more Fos-ir than 20 CRD. Morphological examination of the colon revealed clear signs inflammation but not Acute is a non-noxious stimulus, suggesting...
Objective. A series of experiments were designed to develop and validate an animal model lumbar radiculopathy, More specifically, these investigations introduced a chronic neuropathic pain in the rat associated with clinically relevant nerve root trauma end evaluated ability effect symptoms begin understand underlying neurochemical neurophysiologic factors neurologic abnormalities. Summary Background Data. search literature suggested that studies first attempt distinguish elucidate en...
Abstract Visceral pain is a prevalent clinical problem and one of the most common ailments for which patients seek medical attention. Recent studies have described many physiological properties visceral afferents, but not much known regarding their anatomical characteristics. To determine spinal distribution neurochemical phenotype colonic afferents in rodents, Alexa Fluor‐conjugated cholera toxin‐β (CTB) was injected subserosally into proximal distal portions descending colon Sprague Dawley...
That substance P (SP) contributes in some way to spinal nociceptive processing has been known for many years. However, the contribution of SP and NK-1 receptors generation maintenance inflammatory hyperalgesia or persistent chemical is not clear. The purpose this study was test hypothesis that but using two models pain: carrageenan, which allows testing acute noxious thermal mechanical stimuli, formalin, a model spontaneous pain. Intrathecal pretreatment with receptor antagonist CP-96,345...
Many gastrointestinal pain syndromes are more prevalent in women than men, suggesting a gonadal steroid influence. We characterized the effects of estrogen on two responses to colorectal distention (CRD) rat: visceromotor reflex (vmr) and L6–S1 dorsal horn neuron activity (ABRUPT SUSTAINED neurons). Ovariectomized rats were injected with estrogen, innocuous noxious intensities CRD measured between 4 hr 14 d after injection compared ovariectomized intact, cycling rats. Plasma levels...
This study was performed to determine the impact of inflammatory mediator prostaglandin E 2 (PGE ) on biophysical properties tetrodotoxin resistant voltage-gated Na + currents (TTX-R I in colonic dorsal root ganglion (DRG) neurons. TTX-R studied DRG neurons from thoracolumbar (TL: T 13 –L and lumbosacral (LS: L 6 –S retrogradely labeled following injection DiIC 18 (DiI) into wall descending colon adult male rats. had a high threshold for activation [ V 0.5 conductance-voltage ( G-V) curve =...
Spinal cord application of the κ-opioid receptor agonists dynorphin (50 nmol) or (1S,2S)U-50,488H (0.19–1.9 μmol) produced changes in excitability some superficial dorsal horn nociceptive neurons. One-third cells exhibited expansion their receptive fields as defined using mechanical stimuli following a spinal κ agonist (dynorphin U-50,488H); field expansions were same order those observed immediately after conditioning electrical stimulus applied to peripheral nerve. In addition, U-50,488H...
1. Recordings were made from individual sensory neurons with an A-delta peripheral conduction velocity, either intrasomally in the L7 dorsal root ganglion, or extracellularly Lissauer's Tract close to entry zone. The spinal projection of these afferents was assessed by their antidromic response stimulation columns (DC) (LT) at L5/L6 border. adequate stimulus also ascertained. 2. A-delta-fibers could be divided into two groups: high-threshold mechanoreceptors skin muscle (HTMRs) and...
Central or systemic administration of agonists directed at the mu delta opiate receptors generally produce a greater degree analgesia in males than females. To date, most studies examining sex-based differences opioid have used acute noxious stimuli (i.e., tail-flick and hot plate test); thus potential dimorphic response centrally acting opiates alleviation persistent inflammatory pain is not well established. In present study, right hind paw withdrawal latency (PWL) to radiant thermal was...
Abstract This study determined the extent of rostral projection calcitonin gene‐related peptide‐like immunoreactive (CGRP‐IR) primary afferents in cat lumbosacral spinal cord. To do this we examined distribution CGRP‐like immunoreactivity (CGRP‐LI) contralateral and ipsilateral to multiple dorsal rhizotomies. In cord, CGRP‐IR fibers dwere mostly observed Lissauer's tract, columns, laminae I, II, V. Fewer were III, IV, VI area around central canal. The location CGRP‐LI suggests that arose...
Pain symptoms in several chronic pain disorders women, including irritable bowel syndrome, fluctuate with the menstrual cycle suggesting a gonadal hormone component. In female rats, estrogens modulate visceral sensitivity although underlying mechanism(s) are unknown. present study effects of 17-beta estradiol on N-methyl-D-aspartate (NMDA) receptor signaling colorectal nociceptive processing spinal cord were examined. Estrogen alpha and NR1 subunit NMDA co-expressed dorsal horn neurons,...
We previously reported that 17β-estradiol (E2) is pronociceptive in a visceral pain model the rat. Subcutaneously (s.c.) administered E2 reversed decrease colorectal distention (CRD)-evoked visceromotor response produced by ovariectomy (OVx) and CRD-induced nociceptive responses were greater proestrous rats compared with met/diestrous rats. The site of action, type estrogen receptors activated, possible intracellular signaling pathway involved are yet to be established. In present study,...
<h3>Objective</h3> Epigenetic mechanisms are potential targets to relieve somatic pain. However, little is known whether epigenetic regulation interferes with visceral Previous studies show that oestrogen facilitates This study aimed determine histone hyperacetylation in the spinal cord could attenuate oestrogen-facilitated <h3>Design</h3> The effect of deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on magnitude visceromotor response (VMR) colorectal distention was examined...