A5036526021- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Neurosurgical Procedures and Complications
- Mesenchymal stem cell research
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Cerebrovascular and Carotid Artery Diseases
- Neurobiology and Insect Physiology Research
- Pluripotent Stem Cells Research
- Acute Ischemic Stroke Management
- Neurogenesis and neuroplasticity mechanisms
- S100 Proteins and Annexins
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Herpesvirus Infections and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Bacterial Infections and Vaccines
- Glioma Diagnosis and Treatment
- Biomedical Ethics and Regulation
- Antibiotic Resistance in Bacteria
- Nerve injury and regeneration
- Invertebrate Immune Response Mechanisms
- Pelvic and Acetabular Injuries
- Intracranial Aneurysms: Treatment and Complications
First Affiliated Hospital Zhejiang University
2007-2024
Sun Yat-sen University
2019-2024
Zhejiang University
2008-2023
Sichuan University
2016-2023
Chinese People's Liberation Army
2022-2023
State Key Laboratory of Hydraulics and Mountain River Engineering
2023
Hunan Academy of Agricultural Sciences
2022-2023
Chinese PLA General Hospital
2023
People's Liberation Army 401 Hospital
2022
Medical University of South Carolina
2003-2021
Increasing evidence indicates that activated microglia play an important role in the inflammatory response following traumatic brain injury (TBI). Inhibiting M1 and stimulating M2 have demonstrated protective effects several animal models of central nervous system diseases. However, it is not clear whether polarization to attenuates axonal TBI. In this study, we used a lateral fluid percussion device induce mice. Mice were randomly assigned sham, TBI, TBI + rosiglitazone (peroxisome...
Gastrointestinal dysfunction is a common peripheral organ complication after traumatic brain injury (TBI), yet the underlying mechanism remains unknown. TBI has been demonstrated to cause gut microbiota dysbiosis in animal models, although impacts of on gastrointestinal were not examined. Bile acids are key metabolites between and host interactions. Therefore, aim this study was investigate mechanistic links them by detecting alterations bile acid profile TBI. For that, we established mice...
Exosomes derived from bone marrow mesenchymal stem cells can inhibit neuroinflammation through regulating microglial phenotypes and promoting nerve injury repair. However, the underlying molecular mechanism remains unclear. In this study, we investigated by which exosomes neuroinflammation. Our in vitro co-culture experiments showed that their promoted polarization of activated BV2 microglia to anti-inflammatory phenotype, inhibited expression proinflammatory cytokines, increased cytokines....
Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of cell procedures is an important task professional associations devoted therapy. The Chinese Branch the International Association Neurorestoratology (IANR) completed first set guidelines governing application neurorestoration in 2011. IANR and (CANR) collaborated propose current version "Clinical Therapy Guidelines Neurorestoration (IANR/CANR 2017)". council...
Abstract Traumatic brain injury (TBI) can result in progressive cognitive decline occurring for years after the initial insult, and which there is currently no pharmacological treatment. An ongoing chronic inflammatory response TBI thought to be an important factor driving this decline. Here, we investigate role of complement neuroinflammation up 6 months murine TBI. Male C57BL/6 mice were subjected open head using a controlled cortical impact device. At 2 post TBI, moved large cages with...
Abstract We study the last exit time that a spectrally negative Lévy process is below zero until it reaches positive level b , denoted by $g_{\tau_b^+}$ . generalize results of infinite-horizon explored Chiu and Yin (2005) incorporating random horizon $\tau_b^+$ which represents first passage above derive an explicit expression for joint Laplace transform utilizing hybrid observation scheme approach proposed Li, Willmot, Wong (2018). further optimal prediction in $L_1$ sense, find stopping...
Geniposide, a main iridoid glucoside component of gardenia fruit, has been shown to possess anti-inflammatory activity. However, its potential use for acute lung injury (ALI) not yet studied. The aim this study was evaluate the properties geniposide using mouse ALI model. induced by intranasal injection lipopolysaccharide (LPS). Pretreatment mice with (20, 40, or 80 mg/kg) resulted in marked reduction inflammatory cells and total protein concentration bronchoalveolar lavage fluid (BALF)...
Brainstem hemorrhage (mainly pontine caused by hypertension) has the clinical characteristics of acute onset, rapid progress, high mortality, and disability rate. Due to complexity brainstem's anatomical structure functional importance, it is generally recognized that brainstem treatment difficult risky, so been regarded as a restricted area surgery. However, in recent years, continuous progress being made many areas, including microsurgical technology, stereotactic robot-assisted surgery,...
ABSTRACT Monkeypox virus (MPXV) poses a global health threat. Droplet digital PCR (ddPCR) holds potential as an accurate diagnostic tool for clinical microbiology. However, there is limited literature on the applicability of ddPCR in settings. In this study, features patients with MPXV during initial outbreak China June 2023 were reviewed, and optimized method dilution and/or inhibitor removal was developed to enhance detection efficiency. Eighty-two samples tested from nine different...
Sphingomyelin synthase (SMS) produces sphingomyelin while consuming ceramide (a negative regulator of cell proliferation) and forming diacylglycerol (DAG) mitogenic factor). Therefore, enhanced SMS activity could favor proliferation. To examine if dysregulated contributes to leukemogenesis, we measured in several leukemic lines found that it is highly elevated K562 chronic myelogenous leukemia (CML) cells. The increased cells was caused by the presence Bcr-abl, a hallmark CML; stable...
Brain trauma or traumatic brain injury (TBI) is one of the leading causes death and disability worldwide. Along with conventional therapeutic strategies, neurorestorative treatments for TBI have been developed in recent decades. However, missing standards guidelines has become a growing issue both clinical practice fundamental research. Consequently, Chinese Association Neurorestoratology (Preparatory; CANR) China Committee International (IANR-China Committee) reached consensus to form...
Malignant middle cerebral artery (MCA) infarction is characterized by mortality rate of up to 80%. The aim this study was determine the value decompressive craniectomy in patients presenting malignant MCA compared with those receiving medical treatment alone.Patients treated our hospital between January 1996 and March 2004 were included retrospective analysis. National Institute Health Stroke Scale (NIHSS) used assess neurological status on admission at one week after surgery. All followed...
Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam1) can generate 38,016 different isoforms through largely stochastic, yet highly biased, alternative splicing. These are required for nervous functions. However, the functional significance of splicing bias remains unknown. Here, we provide evidence that Dscam1 is mushroom body (MB) axonal wiring. We mutant flies with normal overall protein levels and an identical number but global changes in exon 4 9 isoform (DscamΔ4D-/-...
Recent evidence suggests that there is a link between gut and brain via microbial, immune, endocrine neural signaling pathways, but the changes of gut-brain axis following trauma has not yet been clearly shown. The aim this study was to reveal microbiota transcriptomic profile cerebral cortex in traumatic injury (TBI) mice.A controlled cortical impact (CCI) device used establish TBI model. Behavioral testing histopathological analysis were performed. analyzed by 16S rRNA sequencing, gene...