A5009196377- Spinal Cord Injury Research
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Biomedical Ethics and Regulation
- RNA Interference and Gene Delivery
- Telomeres, Telomerase, and Senescence
- Cervical and Thoracic Myelopathy
- High Altitude and Hypoxia
- Olfactory and Sensory Function Studies
- Spinal Dysraphism and Malformations
- Organ and Tissue Transplantation Research
- Pain Mechanisms and Treatments
- Advanced biosensing and bioanalysis techniques
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cancer, Hypoxia, and Metabolism
- Pluripotent Stem Cells Research
- Cancer Research and Treatments
- Mesenchymal stem cell research
- Healthcare and Venom Research
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Bioactive natural compounds
First Affiliated Hospital of Henan University of Science and Technology
2022-2025
Luoyang Orthopedic-Traumatological Hospital of Henan Province
2013-2021
Luoyang Central Hospital Affiliated to Zhengzhou University
2006
Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of cell procedures is an important task professional associations devoted therapy. The Chinese Branch the International Association Neurorestoratology (IANR) completed first set guidelines governing application neurorestoration in 2011. IANR and (CANR) collaborated propose current version "Clinical Therapy Guidelines Neurorestoration (IANR/CANR 2017)". council...
Objectives To investigate the safety and therapeutic efficacy of autologous olfactory ensheathing cell (OEC) transplantation in cervical spinal cord injury (SCI). Methods Patients with SCI >6 months’ duration were treated OECs, injected into area surrounding under magnetic resonance imaging guidance, twice a week for 4 weeks. evaluated before treatment at 3, 6, 12 24 months post-treatment, using American Spinal Injury Association (ASIA) Impairment Scale, ASIA sensory motor score...
The aim of the study was to analyze clinical efficacy and safety olfactory ensheathing cell (OEC) transplantation for treating patients with chronic, complete spinal cord injury (SCI). Six six chronic injuries were recruited treated autologous OEC followed 24 months. scores from before after analyzed. This a self-control experiment. There significant amelioration in standard neurological classification made by America Spinal Cord Injury Association (ASIA) International...
The aim of the present study was to evaluate expression vascular endothelial growth factor (VEGF) and hypoxia inducible factor‑1 (HIF‑1), investigate role HIF‑1/VEGF signaling pathway following spinal cord injury (SCI). A total 90 12‑week‑old Sprague Dawley rats were randomly divided into three groups: Sham group (operation without SCI); control (SCI ML228 treatment); treatment receiving treatment). administered as it is an activator HIF‑1α. groups subjected hemisection motor activity...
Olfactory ensheathing cell and spinal cord injury obvious difference between preoperation postoperation measures (P < 0.05).No fevers, infections, functional deteriorations, or deaths were seen.Thus, transplantation of olfactory cells promoted neurofunctional recovery in patients with malignant injuries, this therapeutic method was safe.
We investigated local changes in BMP-2/4 expression rat spinal cords 1 week following injury to study the damage effects of cord (SCI). Sprague Dawley rats (45, 4 months old) were randomized into three groups comprising 15 each: a SHAM group, an SCI without noggin group (SCIO), and with (SCID). The SCIO SCID subjected hemisection, motor activity was assessed using BBB score. Expression each injured section examined by hematoxylin eosin staining, immunohistochemistry, western blot. There no...
Currently, there are many different standards for the quality control of olfactory ensheathing cell (OEC) culture prepared from human bulb and mucosa. It is challenging to compare clinical results OEC treatment hospitals. Based on various standards, Chinese Association Neurorestoratology (CANR; Preparatory) China Committee International (IANR-China Committee) organized professional experts in this field evaluate data develop a standard applications, including donor evaluation, sample...
To investigate the effectiveness of treatment locked lower cervical fracture and dislocation with anterior fusion internal fixation combined release interlocking facet through Luschka joint lamina space.Twelve patients were analyzed retrospectively between January 2013 June 2015. There 7 males 5 females, aged 25-59 years an average age 38.4 years. The disease duration was 9.6 hours to 100 days 7.3 days. 8 cases unilateral locking 4 bilateral locking; old injury fresh injury. injured segments...