A5040928701- Immunotherapy and Immune Responses
- Immune cells in cancer
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Monoclonal and Polyclonal Antibodies Research
- Multiple Myeloma Research and Treatments
- Phagocytosis and Immune Regulation
- Cancer Cells and Metastasis
- Macrophage Migration Inhibitory Factor
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Pregnancy and preeclampsia studies
- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- Glioma Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Chemokine receptors and signaling
- Neonatal Respiratory Health Research
Research Institute of Fundamental and Clinical Immunology
2016-2025
Russian Academy of Sciences
2007-2020
Cellular Research (United States)
2020
Institute of Immunology
2012-2014
Academy of Medical Sciences
2002-2014
Our objective was to evaluate the safety and clinical efficacy of autologous M2 macrophage transplantation in nonacute stroke patients. We also evaluated whether intrathecal administration macrophages influences production cytokines by peripheral blood cells levels correlate with severity responsiveness cell therapy. In this study, 13 patients (12 males 1 female a median age 63 years) diagnosed ischemic (n = 10) or hemorrhagic 3) were subjected therapy (study group). On average, 21.9 × 10(6)...
Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of cell procedures is an important task professional associations devoted therapy. The Chinese Branch the International Association Neurorestoratology (IANR) completed first set guidelines governing application neurorestoration in 2011. IANR and (CANR) collaborated propose current version "Clinical Therapy Guidelines Neurorestoration (IANR/CANR 2017)". council...
Rearrangement of the immune system during pregnancy is a strictly controlled, dynamic process in which first and third trimesters are, respectively, pro-inflammatory, anti-inflammatory periods. However, monocyte involvement regulating pro/anti-inflammatory balance remains poorly understood. The functional phenotype monocytes known to depend on their subsets assessed by CD14 CD16 expression, associated with expression M1(CCR2)- M2(CD206) molecules, pro- activity, respectively. Here we have...
In this part of the study, first component concept “natural genome reconstruction” is being proven. It was shown with mouse and human model organisms that CD34+ hematopoietic bone marrow progenitors take up fragments extracellular double-stranded DNA through a natural mechanism. known process internalization involves glycocalyx structures, which include glycoproteins/protein glycans, glycosylphosphatidylinositol-anchored proteins scavenger receptors. The bioinformatic analysis conducted...
Despite the end of COVID-19 pandemic, there still remain risks new aggressive strains coronavirus. As human population increases progressively, it is mandatory to ensure both preventive measures and an immediate response emerging infectious threats. Another essential component for rapidly restraining a possible pandemic development anticoronaviral therapeutics. In present study, capabilities Gc protein-derived macrophage-activating factor (GcMAF) are characterized. It demonstrated that...
It has been established previously that up to 40% of mouse CD34+ hematopoietic stem cells are capable internalizing exogenous dsDNA fragments both in vivo and ex vivo. Importantly, when mice treated with a combination cyclophosphamide dsDNA, the repair interstrand crosslinks progenitors is attenuated, their pluripotency altered. Here we show for first time among various actively proliferating mammalian cell populations there subpopulations fragments. In context cancer, such...
Abstract It was shown that IgGs from the sera of 2–7‐month‐old control non‐autoimmune (CBA x C57BL)F1 and BALB/c mice 2–3‐month‐old autoimmune prone MRL‐lpr/lpr (conditionally healthy mice) are catalytically inactive. During spontaneous development deep systemic lupus erythematosus (SLE)‐like pathology a specific reorganization immune system these leads to conditions associated with production hydrolyzing DNA, ATP polysaccharides low catalytic activities pre‐diseased mice).A significant...
Recent studies demonstrated that myeloid-derived suppressor cells (MDSCs) are involved in the pathogenesis and progression of multiple myeloma (MM). Nevertheless, data on quantitative functional changes MDSCs during standard MM treatment remain poorly understood. Here, we determined monocytic (M-MDSC; CD14
Macrophages are the immune cells of high-immunological plasticity, which can exert both pro- and anti-inflammatory activity, as well repolarize their phenotype to opposite or neutral one. In this regard, M2 macrophages tumor-associated stroma (TAS) a promising therapeutic target in treating malignant neoplasms. Using FACS assay, we have estimated CD11b+/Ly-6G+/Ly-6C+ fraction from peritoneum TAS intact healthy mice those with developed Lewis carcinoma, untreated treated according Karanahan...
Currently, there is a lack of effective therapeutic methods to restore neurological function for chronic complete spinal cord injury (SCI) by conventional treatment. Neurorestorative strategies with positive preclinical results have been translated the clinic, and some patients gotten benefits their quality life has improved. These include cell therapy, neurostimulation or neuromodulation, neuroprosthesis, neurotization nerve bridging, neurorehabilitation. The aim this consensus 31 experts...
Stem cell-based therapy is considered to be a new approach for the treatment of cerebral palsy (CP). Given potent anti-inflammatory activity and high regenerative potential M2 macrophages, these cells may an alternative source cell transplantation. To evaluate safety efficacy autologous we conducted pilot clinical trial in 21 children with severe CP. The primary outcome measure was safety, which included assessment mortality any cause, immediate adverse reactions, serious effects...
// Ekaterina A. Potter 1 , Evgenia V. Dolgova Anastasia S. Proskurina Alexandra M. Minkevich Yaroslav R. Efremov 1, 2 Oleg Taranov 3 Vladimir Omigov Valeriy P. Nikolin Nelly Popova Sergey I. Bayborodin Alexander Ostanin 4 Elena Chernykh Nikolay Kolchanov Mikhail Shurdov 5 Bogachev Institute of Cytology and Genetics, Siberian Branch the Russian Academy Sciences, Novosibirsk 630090, Russia Department Natural State University, The Research Center Virology Biotechnology VECTOR, 630559, Clinical...
Immature hematopoietic progenitors are a constant source for renewal of hemocyte populations and the basic component tissue cell repair apparatus. A unique property these cells internalizing extracellular double-stranded DNA has been previously shown. The leukostimulatory effect demonstrated in our pioneering studies was considered to be due feature this cell. In present research, we have analyzed effects genome reconstructor preparation (DNAgr), DNAmix, human recombinant angiogenin on both...
Systemic lupus erythematosus (SLE) is an immune-mediated disease that responsive to suppression or modulation of the immune system. Patients with SLE who experience persistent multiorgan dysfunction, despite standard doses intravenous cyclophosphamide (Cy), represent a subset patients at high risk early death. We investigated efficacy and toxicity high-dose immunosuppression autologous hematopoietic stem cell transplantation (SCT) treat such patients. Six (all female, age 15-29 years) severe...
Abstract Background Immunization of mice with tumor homogenate after combined treatment cyclophosphamide (CP) and double-stranded DNA (dsDNA) preparation is effective at inhibition growth challenged the treatment. It was assumed that this might be due to activation antigen-presenting cells. The purpose develop improved antitumor strategy using mice. We studied action cytostatics doxorubicin (Dox) plus CP subsequent dsDNA on growth. Methods Three-month old CBA/Lac were used in experiments....
The phenotypic and functional features of human M2 macrophages, in particular, their immunosuppressive activity, can considerably vary depending on polarizing stimulus. This study was aimed at the investigation cytokine production pro-apoptogenic/inhibitory molecule expression macrophages generated with GM-CSF using either standard conditions (M1) or deficiency serum/growth factors (M2-LS cells). In contrast to M1, M2-LS cells were characterized by an enhanced content CD206(+), B7-H1(+),...