A5065405207- Muscle activation and electromyography studies
- Muscle Physiology and Disorders
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Advanced Sensor and Energy Harvesting Materials
- Cerebral Palsy and Movement Disorders
- Spinal Cord Injury Research
- Stroke Rehabilitation and Recovery
- Balance, Gait, and Falls Prevention
- Musculoskeletal pain and rehabilitation
- Exercise and Physiological Responses
- Sports Performance and Training
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nutrition and Health in Aging
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Neurogenetic and Muscular Disorders Research
- Genetic Neurodegenerative Diseases
- Sports injuries and prevention
- Botulinum Toxin and Related Neurological Disorders
- Tissue Engineering and Regenerative Medicine
- Planarian Biology and Electrostimulation
- Effects of Vibration on Health
- Children's Physical and Motor Development
- Prosthetics and Rehabilitation Robotics
Ludwig Boltzmann Institute for Digital Health and Prevention
2004-2024
Ludwig Boltzmann Institute for Cancer Research
2019-2023
Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation
2013-2022
Universitätsklinikum St. Pölten
2022
University of Iceland
2020
National University Hospital of Iceland
2020
University of Padua
2009-2020
Wilhelminen Hospital
2009-2019
St. Pölten University of Applied Sciences
2017-2019
Weatherford College
2019
Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is unknown. Here, we find that sedentary not active humans display an age-related decline in the mitochondrial protein, optic atrophy 1 (OPA1), associated with muscle loss. In adult mice, acute, muscle-specific deletion of Opa1 induces a precocious phenotype and premature death. Conditional inducible alters morphology function DNA content. Mechanistically, ablation leads to ER stress, which signals via...
The cellular basis of age-related tissue deterioration remains largely obscure.The ability to activate compensatory mechanisms in response environmental stress is an important factor for survival and maintenance functions.Autophagy activated both under short prolonged required clear the cell dysfunctional organelles altered proteins.We report that specific autophagy inhibition muscle has a major impact on neuromuscular synaptic function and, consequently, strength, ultimately affecting...
Aging is usually accompanied by a significant reduction in muscle mass and force. To determine the relative contribution of inactivity aging per se to this decay, we compared function structure (a) male participants belonging group well-trained seniors (average 70 years) who exercised regularly their previous 30 years (b) age-matched healthy sedentary with (c) active young men 27 years). The results collected show that cohorts, from senior sportsmen have: greater maximal isometric force...
Abstract Recent studies have correlated physical activity with a better prognosis in cachectic patients, although the underlying mechanisms are not yet understood. In order to identify pathways involved activity-mediated rescue of skeletal muscle mass and function, we investigated effects voluntary exercise on cachexia colon carcinoma (C26)-bearing mice. Voluntary prevented loss ultimately increasing survival C26-bearing We found that autophagic flux is overloaded both murine models but...
Continuous epidural stimulation of lumbar posterior root afferents can modify the activity cord networks and motoneurons, resulting in suppression spasticity or elicitation locomotor-like movements spinal cord-injured people. The aim present study was to demonstrate that also be depolarized by transcutaneous with moderate stimulus intensities. In healthy subjects, single stimuli applied through surface electrodes placed over T11-T12 vertebrae a mean intensity 28.6 V elicited simultaneous,...
Over the last 30 years there has been considerable interest in use of functional electrical stimulation (FES) to restore movement limbs paralyzed patients. Spinal cord injury causes a rapid loss both muscle mass and contractile force. The atrophy is especially severe when involves lower motoneurons because many months after spinal injury, complicated by fibrosis fat substitution. In this study we describe effects long-term motoneuron denervation human present structural results trained using...
Background. Spinal cord injury causes muscle wasting and loss of function, which are especially severe after complete permanent damage to lower motor neurons. In a previous cross-sectional study, long-standing denervated muscles were rescued by home-based functional electrical stimulation (h-bFES) training. Objective. To confirm results 2-year longitudinal prospective study 25 patients with conus/cauda equina lesions. Methods. Denervated leg stimulated h-bFES using custom-designed stimulator...
The relative importance of muscle activity versus neurotrophic factors in the maintenance differentiation has been greatly debated. Muscle biopsies from spinal cord injury patients, who were trained with an innovative protocol functional electrical stimulation (FES) for prolonged periods (2.4-9.3 years), offered unique opportunity studying structural recovery denervated fibers severe atrophy under sole influence activity. FES induced surprising structure, mass, and force even patients whose...
We investigated the restorative potential of intensive electrical stimulation in a patient with long-standing quadriceps denervation. Stimulation started 18 months after injury. After 26 months, thighs were visibly less wasted. Muscle cross-sectional areas, measured by computerized tomography, increased from 36.0 cm2 to 57.9 (right) and 36.1 52.4 (left). Knee torque had become sufficient maintain standing without upper extremity support. Biopsies revealed evidence both growth regeneration...
The histologic features of aging muscle suggest that denervation contributes to atrophy, immobility accelerates the process, and routine exercise may protect against loss motor units tissue. Here, we compared biopsies from sedentary physically active seniors found with a long history high-level recreational activity up time biopsy had 1) lower strength versus young men (32% in vs 51% seniors); 2) fewer small angulated (denervated) myofibers; 3) higher percentage fiber-type groups...
Context/objective: To examine the effects of transcutaneous spinal cord stimulation (tSCS) on lower-limb spasticity.Design: Interventional pilot study to produce preliminary data.
The loss in muscle mass coupled with a decrease specific force and shift fiber composition are all marks of aging. Training regular exercise attenuate the signs sarcopenia. However, pathologic conditions limit ability to perform physical exercise. We addressed whether electrical stimulation (ES) is an alternative intervention improve recovery defined molecular mechanism associated improvement structure function. analyzed, at functional, structural, level, effects ES training on healthy...
Abstract The level of sustainable excitability within lumbar spinal cord circuitries is one the factors determining functional outcome locomotor therapy after motor‐incomplete injury. Here, we present initial data using noninvasive transcutaneous stimulation (t SCS ) to modulate this central state during voluntary treadmill stepping in three cord‐injured individuals. Stimulation was applied at 30 Hz with an intensity that generated tingling sensations lower limb dermatomes, yet without...
Spinal cord injury (SCI) causes muscle atrophy, which is particularly severe, due to inability perform tetanic contractions, when lower motor neurons (LMN) are involved. We performed a longitudinal study in 25 Europeans suffering from complete conus cauda syndrome 0.7 8.7 years comparing functional and structural thigh properties before after 2 of home-based daily training by electrical stimulation (FES). The mid-term results 1 year preliminary biopsy observations at project end-point subset...
// Laura Pietrangelo 1,* , Alessandra D'Incecco Alina Ainbinder 2 Antonio Michelucci 1 Helmut Kern 3 Robert T. Dirksen Simona Boncompagni and Feliciano Protasi CeSI - Center for Research on Aging & DNICS, Department of Neuroscience, Imaging Clinical Sciences, University G. d'Annunzio, Chieti, Italy Pharmacology Physiology, Rochester School Medicine Dentistry, Rochester, NY, USA Ludwig Boltzmann Institute Electrical Stimulation Physical Rehabilitation Rehabilitation, Wilhelminenspital,...
This paper describes a novel approach to determine structural changes in bone, muscle, and tendons using medical imaging, finite element models, processing techniques evaluate quantify: (1) progression of atrophy permanently lower motor neuron (LMN) denervated human muscles, tendons; (2) their recovery as induced by functional electrical stimulation (FES); (3) bone mineral density strength effect FES treatment.Briefly, we used three-dimensional reconstruction muscle belly, tendons, images...
Abstract Age‐related sarcopenia is characterized by a progressive loss of muscle mass with decline in specific force, having dramatic consequences on mobility and quality life seniors. The etiology multifactorial underlying mechanisms are currently not fully elucidated. Physical exercise known to have beneficial effects trophism force production. Alterations mitochondrial Ca 2+ homeostasis regulated calcium uniporter ( MCU ) been recently shown affect vivo mice. To understand the relevance...
Background/Study Context: The capacity to perform everyday tasks is directly related the muscular power body can develop (see Appendix). age-related loss of a fact, but characterization or rate muscle remains an open issue. Data useful study decline skeletal muscles are largely available from sources other than medical tests, e.g., track and field competitions Masters athletes. aim our identify trend developed by athletes in carrying out events.Methods: Absolute male world records 16 events...