A5063880794- Trace Elements in Health
- RNA modifications and cancer
- Iron Metabolism and Disorders
- Circadian rhythm and melatonin
- Lymphatic System and Diseases
- Adipose Tissue and Metabolism
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Heavy Metal Exposure and Toxicity
- Exercise and Physiological Responses
- Cancer-related gene regulation
- Estrogen and related hormone effects
- Cell Adhesion Molecules Research
- Cardiac Fibrosis and Remodeling
- Angiogenesis and VEGF in Cancer
- Thyroid Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- Protease and Inhibitor Mechanisms
- Muscle Physiology and Disorders
- Breast Cancer Treatment Studies
- Tendon Structure and Treatment
Wroclaw Medical University
2016-2025
Wroclaw University of Health and Sport Sciences
2006-2023
University of Wrocław
2004-2020
Wroclaw Research Centre EIT+ (Poland)
2014-2020
Łukasiewicz Research Network – PORT Polish Center for Technology Development
2014
General Department of Preventive Medicine
2013
University of Padua
1997-2004
The latest immunotherapy, used in the treatment of non-small cell lung cancer (NSCLC), uses monoclonal antibodies directed against programmed death ligand 1 (PD-L1) to inhibit its interaction with PD-1 receptor. Elevated levels PD-L1 expression were observed on NSCLC cells. association between and clinicopathological features is still unclear. Therefore, we examined this relationship also compare Ki-67, p63 TTF-1.866 samples NSCLCs prepare tissue microarrays (TMAs) which immunohistochemical...
Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic adds complexity to traditional cell cultivation methods. most commonly used technique involves cultivating cells on flat surface in two-dimensional format due its simplicity. A three-dimensional (3D) provide microenvironment for surrounding cells. There two main techniques obtaining 3D...
Over the last 30 years there has been considerable interest in use of functional electrical stimulation (FES) to restore movement limbs paralyzed patients. Spinal cord injury causes a rapid loss both muscle mass and contractile force. The atrophy is especially severe when involves lower motoneurons because many months after spinal injury, complicated by fibrosis fat substitution. In this study we describe effects long-term motoneuron denervation human present structural results trained using...
Apoptosis plays a major role in several diseases, including viral infections, autoimmune cancer, cardiac infarct, and neurological disorders. To investigate the of apoptosis muscular dystrophy, dystrophin-deficient (mdx) mice were subjected to spontaneous exercise skeletal muscles analyzed for ubiquitin. The increase apoptotic myonuclei after was detected by TUNEL, electron microscopy, DNA analyses high molecular weight ladder fragments. Expression ubiquitin correlated with positive...
Pula B, Jethon A, Piotrowska Gomulkiewicz Owczarek T, Calik J, Wojnar Witkiewicz W, Rys Ugorski M, Dziegiel P & Podhorska-Okolow M (2011) Histopathology 59, 1249–1260 Podoplanin expression by cancer-associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma Aims: It has recently been shown that podoplanin, a mucin-type glycoprotein, is expressed cancer cells and (CAFs), promotes cell migration invasiveness. The biological role of podoplanin tumour stroma the (IDC) not...
In humans, two main types of membrane melatonin receptors have been identified, MT1 and MT2. Expression in neoplastic cells seems to increase the efficacy melatonin's oncostatic activity. The purpose this study was determine distribution intensity expression breast cancer correlate it with clinicopathological factors. Immunohistochemical studies (IHC) were conducted on 190 cases invasive ductal carcinomas (IDC) molecular performed 29 frozen tumor fragments selected cell lines. Most studied...
The aim of the study was to evaluate localization and intensity RNA-binding motif single-stranded-interacting protein 3 (RBMS3) expression in clinical material using immunohistochemical (IHC) reactions cases ductal breast cancer (in vivo), determine level RBMS3 at both mRNA levels cell lines vitro). Moreover, data obtained vivo vitro studies were correlated with clinicopathological profiles patients. Material for IHC comprised 490 invasive carcinoma (IDC) 26 mastopathy tissues. Western blot...
It was shown recently on the level of gene expression that UGT8, coding UDP-galactose:ceramide galactosyltransferase, is one six genes whose elevated correlated with a significantly increased risk lung metastases in breast cancer patients. In this study primary tumours and their as well cell lines were analysed for UGT8 at protein level.Expression tissue specimens using IHC, real-time PCR Western blotting.Comparison average values reaction intensities (IRS scale) showed significant...
Background: The microenvironment of solid tumours is significant in cancer development and progression. aim this study was to determine periostin (POSTN) expression by cancer-associated fibroblasts (CAFs) non-small-cell lung (NSCLC), as well assess associations with clinicopathological factors prognosis. Materials Methods: Immunohistochemical analysis POSTN performed on NSCLC (N = 700) non-malignant tissue (NMLT) 110) using microarrays. Laser capture microdissection (LCM) for isolation...
With their ability to cross the blood-brain barrier, transport and regulate release of various signaling molecules, extracellular vesicles (EVs) constitute a novel avenue study intercellular communication in pathologies, including psychiatric disorders. We studied 34 major depressive disorder (MDD) patients 57 healthy controls characterized EVs isolated from plasma using digital holographic tomography (DHT) nanoparticle tracking analysis (NTA). detected DHT were markedly smaller less...
Abstract Background Extracellular vesicles (EVs) play a crucial role in facilitating intercellular communication. Their capacity to traverse the blood-brain barrier, transport, and control release of diverse neurotransmitters underscores their potential involvement pathophysiology psychiatric disorders (1). The small size biogenesis EVs complicates detection investigation (2). However, exosomal markers, including CD63 CD9, may provide convenient method for major depressive disorder (MDD)....