A5067741893- DNA Repair Mechanisms
- Endometriosis Research and Treatment
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Estrogen and related hormone effects
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Pharmacological Effects and Toxicity Studies
- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Drug Transport and Resistance Mechanisms
- Carcinogens and Genotoxicity Assessment
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Uterine Myomas and Treatments
Polish Mother’s Memorial Hospital Research Institute
2016-2025
Medical University of Lodz
2021
Laboratory of Molecular Genetics
2012-2016
Central Office of Measures
2015
University of Computer Sciences and Skills
2013-2014
Memorial Hospital of South Bend
2011-2012
Cancer cells have accelerated metabolism and high glucose requirements. The up-regulation of specific transporters may represent a key mechanism by which malignant achieve increased uptake to support the rate glycolysis. In present study we analyzed mRNA protein expression GLUT1 GLUT3 quantitative real-time polymerase chain reaction (Q-PCR) Western blotting technique in 76 cases endometrial carcinoma 70 breast carcinoma. SLC2A1 SLCA2A3 mRNAs was found, respectively 100% 97.4% samples cancers...
O-GlcNAcylation is an abundant, dynamic, and inducible posttranslational modification in which single β-N-acetylglucosamine residues are attached by O-glycosidic linkage to serine or treonine residues. It suggested that abnormally regulated may contribute the pathology of cancer. Cycling O-GlcNAc on intracellular proteins controlled two enzymes, transferease (OGT), catalyses addition nucleocytoplasmic β-N-acetylglucosaminidase (O-GlcNAcase; encoded MGEA5 gene), enzyme involved removal...
The aim of the study was to evaluate localization and intensity RNA-binding motif single-stranded-interacting protein 3 (RBMS3) expression in clinical material using immunohistochemical (IHC) reactions cases ductal breast cancer (in vivo), determine level RBMS3 at both mRNA levels cell lines vitro). Moreover, data obtained vivo vitro studies were correlated with clinicopathological profiles patients. Material for IHC comprised 490 invasive carcinoma (IDC) 26 mastopathy tissues. Western blot...
Abstract A checkpoint protein called the V-domain Ig suppressor of T cell activation (VISTA) is important for controlling immune responses. Immune cells that interact with VISTA have molecules, or receptors, known as receptors. system activity can be modified by interaction between and its Since targeting receptors may beneficial in certain conditions, has been studied relation to immunotherapy cancer autoimmune illnesses. The purpose this study was examine expression levels interactions...
Breast cancer (BC) is the most common in women, and a higher level of prolactin-induced protein (PIP) associated with better responses to adjuvant chemotherapy. The signal transducer activator transcription 5 (STAT5) potential regulator PIP gene. Prolactin (PRL) its receptor (PRLR) activate JAK2/STAT5 signaling BC, which modulated by inhibitors like suppressors cytokine (SOCS) proteins activated STAT (PIAS). Using real-time PCR immunohistochemistry, we studied relationship between STAT5 BC....
Abstract Endometriosis is a common complex inflammatory condition characterised by the presence of endometrium-like tissue outside uterus, mainly in pelvic area. It associated with chronic pain and infertility, its pathogenesis remains poorly understood. The disease typically classified according to revised American Fertility Society (rAFS) 4-stage surgical assessment system, although stage does not correlate well symptomatology or prognosis. Previously identified genetic variants are III/IV...
Objectives. Endometriosis is supported by hormonal, immunological, and environmental factors. No specific marker for endometriosis has yet been identified. ESR2 CYP19A1 genes play a major role in the hormonal control of women, development which largely depends on steroid hormones. Aim. An analysis allele-specific gene expressions context risk occurrence. Methods. The study material included paraffin-embedded tissue specimens, collected from patients ( <a:math...
Irisin is a myokine formed from fibronectin type III domain-containing protein 5 (FNDC5), which can be found in various cancer tissues. FNDC5 and irisin levels have been poorly studied the tumor tissues of breast (BC). The aim this study was to determine expression BC compare them clinicopathological factors Ki-67 PGC-1α levels. Tissue microarrays (TMAs) with 541 61 samples non-malignant disease (NMBD; control) were used perform immunohistochemical reactions. gene measured 40 tissue samples,...
XRCC2 and XRCC3 genes involved in homologous recombination repair (HRR) of DNA the maintenance genome integrity play a crucial role protecting against mutations that lead to cancer. The aim present work was evaluate associations between risk triple-negative breast cancer (TNBC) polymorphisms genes, encoding for two key proteins HRR: Arg188His (c. 563 G>A; rs3218536, Genbank Accession Number NT 007914) Thr241Met 722 C>T; rs861539, 026437). were investigated by PCR-RFLP 70 patients with TNBC...
Triple-negative breast cancer (TNBC) refers to about 15-20% of all cases. It is characterized by worse clinical outcome, poor prognosis, and absence prognostic indicators. Several polymorphisms in the nucleotide excision repair (NER) base (BER) gene have been extensively studied association with various human cancers. The aim this study was evaluate role hOGG1-Ser326Cys (rs13181), XRCC1-Arg194Trp (rs1799782), ERCC2-Lys751Gln (rs13181) parameters risk for development triple-negative cancer....
Epilepsy is a disease of neurological character. Approximately one third epileptic patients demonstrate drug-resistant phenotype, which associated with the development epilepsy. The multidrug resistance protein 1 and glycoprotein P, encoded by MDR1, play significant role in transmembrane transport anti-epileptic agents. Single nucleotide polymorphism C3435T (rs1045642) within MDR1 gene may be an increased expression P-gp affects levels antiepileptic drugs plasma. presented studies analysed...
The aim of the study was to determine relationship between single nucleotide polymorphisms (SNPs) DNA repair genes and modulation risk breast cancer. following SNPs were analysed: XRCC1-Arg399Gln (rs25487), hMSH2-Gly322Asp (rs4987188), XRCC2-Arg188His (rs3218536), XPD- Lys751Gln (rs13181), RAD51--4719A/T (rs2619679) RAD51--4601A/G (rs5030789).The included n = 600 patients: 300 with cancer healthy controls. HRM (High-Resolution Melter) technique applied for polymorphism analysis. Odds ratios...