A5006935659- Muscle Physiology and Disorders
- Autophagy in Disease and Therapy
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Nutrition and Health in Aging
- Exercise and Physiological Responses
- Histone Deacetylase Inhibitors Research
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Diversity and Impact of Dance
- Intracerebral and Subarachnoid Hemorrhage Research
- Adipose Tissue and Metabolism
- biodegradable polymer synthesis and properties
- Musculoskeletal Disorders and Rehabilitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Musicians’ Health and Performance
- Inflammatory Myopathies and Dermatomyositis
Sapienza University of Rome
2015-2022
Institut de Myologie
2015-2017
Abstract Recent studies have correlated physical activity with a better prognosis in cachectic patients, although the underlying mechanisms are not yet understood. In order to identify pathways involved activity-mediated rescue of skeletal muscle mass and function, we investigated effects voluntary exercise on cachexia colon carcinoma (C26)-bearing mice. Voluntary prevented loss ultimately increasing survival C26-bearing We found that autophagic flux is overloaded both murine models but...
Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed NF‐kB‐induced Pax7 overexpression impairs myogenic potential of precursors cachectic mice, suggesting lowering expression may be beneficial evaluated regenerative after acute injury C26 colon carcinoma tumor‐bearing mice and healthy controls. Our analyses confirmed delayed regeneration observed muscles form was associated with persistent local inflammation overexpression....
Histone deacetylase 4 (HDAC4) has been proposed as a target for Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction and since its expression in skeletal correlates with the severity of disease. However, our recent studies on response upon long-term denervation highlighted importance HDAC4 maintaining integrity.To fully identify yet uncharacterized functions ALS, we genetically deleted muscles mouse model ALS. Body weight, muscle, innervation spinal cord...
Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy. Histone deacetylase 4 (HDAC4) mediates response denervation, suggesting use HDAC inhibitors as a therapeutic approach neurogenic However, effects HDAC4 inhibition long-term denervation have not been described yet. To further study functions we analyzed mutant mice which is specifically deleted muscle. After an...
Denervation leads to the activation of catabolic pathways, such as ubiquitin-proteasome and autophagy, resulting in skeletal muscle atrophy weakness. Furthermore, denervation induces oxidative stress muscle, which is thought contribute induction atrophy. Several diseases are characterized by denervation, but molecular pathways contributing have been only partially described. Our study delineates kinetics response following denervation. Despite denervation-dependent treatments with...
Physiological autophagy plays a crucial role in the regulation of muscle mass and metabolism, while excessive induction or inhibition autophagic flux contributes to progression several diseases. Autophagy can be activated by different stimuli, including cancer, exercise, caloric restriction denervation. The latter leads atrophy through activation catabolic pathways, i.e. ubiquitin-proteasome system autophagy. However, kinetics upstream molecular pathways denervated skeletal have not been...
OPINION article Front. Physiol., 08 January 2019Sec. Striated Muscle Physiology Volume 9 - 2018 | https://doi.org/10.3389/fphys.2018.01885
Amyotrophic Lateral Sclerosis (ALS) is a devastating adult-onset neurodegenerative disease, with ineffective therapeutic options. ALS incidence and prevalence depend on the sex of patient. Histone deacetylase 4 (HDAC4) expression in skeletal muscle directly correlates progression ALS, pointing to use HDAC4 inhibitors for its treatment. Contrarily, we have found that deletion worsened pathological features accelerating exacerbating loss negatively affecting innervations male SOD1-G93A (SOD1)...
Epigenetics plays a pivotal role in modulating gene response to physiological or pathological stimuli. Histone Deacetylase inhibitors (HDACi) have been used the treatment of various cancers1, are effective several animal models neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and currently clinical trial promote muscle repair muscular dystrophies2. However, long-term use pan-HDAC is not tolerated3. The assignment distinct biological functions individual HDACs...