A5037410853- Multiple Sclerosis Research Studies
- Anesthesia and Neurotoxicity Research
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Ischemia and Reperfusion
- Cancer, Hypoxia, and Metabolism
- S100 Proteins and Annexins
- Peripheral Neuropathies and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Migraine and Headache Studies
- Renal and related cancers
- Prion Diseases and Protein Misfolding
- Hereditary Neurological Disorders
- Sleep and Wakefulness Research
- Boron Compounds in Chemistry
- Cardiac Fibrosis and Remodeling
- Growth Hormone and Insulin-like Growth Factors
- Genetic Neurodegenerative Diseases
- Sphingolipid Metabolism and Signaling
- Myasthenia Gravis and Thymoma
- CNS Lymphoma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Polyomavirus and related diseases
- CRISPR and Genetic Engineering
Soochow University
2012-2024
First Affiliated Hospital of Soochow University
2013-2024
Nantong University
2024
Affiliated Hospital of Nantong University
2024
Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of cell procedures is an important task professional associations devoted therapy. The Chinese Branch the International Association Neurorestoratology (IANR) completed first set guidelines governing application neurorestoration in 2011. IANR and (CANR) collaborated propose current version "Clinical Therapy Guidelines Neurorestoration (IANR/CANR 2017)". council...
Local inflammatory microenvironment in the early stage of myocardial infarction (MI) severely impaired cardiac recovery post-MI. Macrophages play a pivotal role this process. A classical glycolytic inhibitor, 2-Deoxy-Glucose (2-DG), has been found to regulate excessive pro-inflammatory macrophage polarization infarcted myocardium. This study investigated effect 2-DG-loaded chitosan/gelatin composite patch on infarct post-MI and its impact repair. The results showed that 2-DG significantly...
Synaptotagmin III (Syt3) is a Ca2+-dependent membrane-traffic protein that highly concentrated in synaptic plasma membranes and affects plasticity by regulating post-synaptic receptor endocytosis. Here, we show Syt3 upregulated the penumbra after ischemia/reperfusion (I/R) injury. Knockdown of protects against I/R injury, promotes recovery motor function, inhibits cognitive decline. Overexpression exerts opposite effects. Mechanistically, injury augments Syt3-GluA2 interactions, decreases...
Observational studies have reported a link between particulate matter 2.5 (PM2.5) and the risk of mental disorders; however, causality is unclear. Using publicly available genome-wide association studies, we conducted two-sample Mendelian randomization (MR) study to assess causal relationship PM2.5 six disorders: attention deficit hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), schizophrenia (SCZ), anxiety (ANX). The inverse-variance weighting...
Amniotic fluid stem cells (AFSCs) are a type of fetal cell whose stemness encompasses both embryonic and adult cells, suggesting that they may be easily efficiently reprogrammed into induced pluripotent (iPSCs).To further simplify the reprogramming process, creation AFSC-derived iPSCs using single factor is desirable.Here we report generation one-factor human AFSC-iPSCs (AiPSCs) from AFSCs by ectopic expression transcription OCT4. Just like AiPSCs exhibited similar epigenetic status, global...
Cerebrospinal fluid oligoclonal band (CSF-OCB) is an established biomarker in diagnosing multiple sclerosis (MS), however, there are no nationwide data on CSF-OCB prevalence and its diagnostic performance Chinese MS patients, especially the virtue of common standard operation procedure (SOP). With a consensus SOP same isoelectric focusing system, we conducted multi-center study OCB status consecutively, recruited 483 patients 880 non-MS including neuro-inflammatory diseases (NID, n = 595)...
Background Primary cardiac tumors are uncommon, with the majority being benign myxomas. Cystic myxoma, a particularly rare type of tumor, demands cautious differential diagnosis from other tumors. Case summary A 43-year-old male patient presenting intermittent dyspnea was referred to our department for surgical evaluation. Transthoracic echocardiography (TTE) and transesophageal (TEE) unveiled an intra-left atrial cyst, which subsequently found be blood-filled during video-assisted...
Rationale: Neuronal intranuclear inclusion disease (NIID) is a slowly progressing neurodegenerative with various manifestations and high heterogeneity. Clinical characteristics, imaging, skin biopsy, genetic testing are necessary for its diagnosis. Electromyography may also be useful tool diagnosing NIID. In this study, we report patient motor sensory nerve demyelination changes accompanied by axonal damage. Patient concerns: A 64-year-old woman was admitted to our department gradually...
Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Th1 cells play an important role in the pathogenesis experimental encephalomyelitis. This study determined potential effect programmed cell death 1 ligand induced by injecting myelin oligodendrocyte glycoprotein, complete Freund's adjuvant Bordetella pertussis toxin into C57BL/6J mice. mice developed disease showed inflammatory changes central nervous system...
Objective To discuss the clinical significance of programmed cell death-1 (PD-1) in neuromyelitis optica spectrum disorder (NMOSD) patients by analyzing PD-1 and death 1-ligand (PD-L1) expressions. Methods Sixteen with NMOSD, 16 longitudinally extensive transverse myelitis (LETM), 13 opticneuritis (ON), 20 other diseases central nervous system (OTH) health controls (CONs) were chosen our hospital from April 2015 to July 2016; their peripheral blood was separately collected. The...