A5045765012- Multiple Sclerosis Research Studies
- T-cell and B-cell Immunology
- Peripheral Neuropathies and Disorders
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Hereditary Neurological Disorders
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Nerve injury and regeneration
- Circadian rhythm and melatonin
- Parkinson's Disease Mechanisms and Treatments
- Autoimmune and Inflammatory Disorders Research
- Mesenchymal stem cell research
- Mycobacterium research and diagnosis
- Polyomavirus and related diseases
- CNS Lymphoma Diagnosis and Treatment
- Inflammatory Bowel Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Autoimmune Neurological Disorders and Treatments
- Anesthesia and Sedative Agents
- Biochemical effects in animals
First Hospital of Jilin University
2016-2025
Jilin University
2016-2025
First Affiliated Hospital of Zhengzhou University
2024
Jiangsu University
2024
China Agricultural University
2024
Yixing People's Hospital
2024
Karolinska Institutet
2006-2020
82th Hospital of Pla
2020
Second Xiangya Hospital of Central South University
2020
Central South University
2020
Background This study was aimed to examine circadian variations of hepatic antioxidant components, including the Nrf2- pathway, glutathione (GSH) system, enzymes and metallothionein in mouse liver. Methods Results Adult mice were housed light- temperature-controlled facilities for 2 weeks, livers collected every 4 h during 24 period. Total RNA isolated, purified, subjected real-time RT-PCR analysis. Hepatic mRNA levels Nrf2, Keap1, Nqo1 Gclc higher light-phase than dark-phase,...
Multiple sclerosis (MS) is a neuro-autoimmune and neurodegenerative disorder leading to chronic inflammation, demyelination, axonal, neuronal loss in the central nervous system (CNS). Despite intense research efforts, pathogenesis of MS still remains unclear. Toll-like receptors (TLRs) are family type I transmembrane that play crucial role innate immune response. Myeloid differentiation factor 88 (MyD88) adaptor major TLRs. It has been widely considered TLR-MyD88 signaling pathway plays an...
Sex differences and circadian variation are two major factors that affect the expression of drug-processing genes. This study aimed to examine sex in hepatic cytochrome P450 (Cyp) genes corresponding nuclear receptors. Adult mice were acclimated environmentally controlled facilities for 2 wks, livers collected every 4 h during a 24-h period. Total RNA protein isolated subjected real-time reverse transcriptase–polymerase chain reaction (RT-PCR) Western blot analysis. The mRNA aryl hydrocarbon...
Summary Dendritic cells ( DC s), a bridge for innate and adaptive immune responses, play key role in the development of multiple sclerosis MS ) experimental autoimmune encephalomyelitis EAE ), an animal model . Administration tolerogenic s has been used as immunotherapy diseases. Deficiency vitamin D is environmental risk factor In this study, we induced by 1,25‐dihydroxyvitamin 3 transferred VD ‐ s) into mice adoptive transfer. We found that inhibited infiltrations T helper type 1 (Th1)...
The Guillain-Barré syndrome (GBS) is considered a T helper 1 (Th1) cells-mediated acute inflammatory peripheral neuropathy. However, some changes in GBS could not be explained completely by Th1 cells pathogenic role. Recently, Th17 have been identified and can mediate tissue inflammation autoimmune response. Therefore, study on the role of Th22 their cytokines necessary for exploring pathogenesis GBS. Here, we detected frequency Th1, Th17, using 4-color flow cytometry plasma levels IL-17...
Objective This study is aimed at examining the potential roles of circulating memory T follicular helper (Tfh) cells in patients with multiple sclerosis (MS). Methods The numbers different subsets Tfh 25 relapsed MS before and after treatment as well 14 healthy controls (HC) were examined by flow cytometry. levels plasma IL-21 all cerebrospinal fluid (CSF) some non-inflammatory neuronal diseases (NND) measured ELISA. Results In comparison that HC, CD3+CD4+CXCR5+CD45RA-, ICOS+, CCR7+...
Background: It has been reported that dexmedetomidine (DEX) can be used for conscious sedation in awake craniotomy, but few data exist to compare DEX versus propofol (PRO). Objective: To the efficacy and safety of PRO craniotomy. Methods: Thirty patients American Society Anesthesiologists grade I-II scheduled were randomized into 2 groups each containing 15 subjects. Group D received group P PRO. Two minutes after tracheal intubation (T1), (target plasma concentration) was titrated down 1 4...
Abstract Circulating memory T follicular helper subsets, Tfh2 and Tfh17 are found to be aberrantly regulated in many autoimmune diseases. However, their roles the pathogenesis of GBS still unclear. This study examined phenotype, distribution, clinical relevance potential function 36 patients (including 24 AMAN 12 AIDP patients). We that absolute counts total Tfh cells were significantly increased AMAN, while no significant difference compared with HC. Furthermore, levels three subsets cells,...
Increased protein level in the cerebrospinal fluid (CSF) is a characteristic of patients with Guillain–Barré syndrome (GBS), an acute inflammatory autoimmune disorder peripheral nervous system (PNS). However, molecular mechanisms underlying disease remain poorly understood and so far no reliable disease‐related markers are available. By comparing CSF proteome GBS control subjects suffering from other neurological disorders, it may be possible to identify proteins that involve process thus...
Objective . This study aimed to examine the potential role of memory T follicular helper (Tfh) cells in patients with neuromyelitis optica/neuromyelitis optica spectrum disorders (NMO/NMOSD). Methods The percentages different subsets circulating Tfh 25 NMO/NMOSD before and after treatment as well 17 healthy controls were examined by flow cytometry. levels IL-21 AQP4 Ab plasma CSF measured ELISA. Results numbers cells, ICOS + , CCR7 − significantly increased patients. positively correlated...