A5035515415- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Angiogenesis and VEGF in Cancer
- Adipose Tissue and Metabolism
- Ovarian function and disorders
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Sperm and Testicular Function
- Regulation of Appetite and Obesity
- Neonatal and Maternal Infections
- Atrial Fibrillation Management and Outcomes
- Reproductive Biology and Fertility
- Arsenic contamination and mitigation
- Obstructive Sleep Apnea Research
- Advanced Glycation End Products research
- Cardiovascular and Diving-Related Complications
- Sarcoma Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Pleural and Pulmonary Diseases
- Gastrointestinal motility and disorders
- Infant Health and Development
- Mast cells and histamine
- Lipid metabolism and disorders
- Gastrointestinal Tumor Research and Treatment
- Ectopic Pregnancy Diagnosis and Management
University of Shanghai for Science and Technology
2024
Hangzhou Medical College
2018-2023
Zhejiang Provincial People's Hospital
2013-2023
Anhui Medical University
2022-2023
First Affiliated Hospital of Anhui Medical University
2022-2023
Sichuan University
2015-2022
West China Hospital of Sichuan University
2015-2022
First Affiliated Hospital of Zhengzhou University
2022
The First People’s Hospital of Lianyungang
2020
Weatherford College
2020
The factors underlying the survival and maintenance of interstitial cells Cajal (ICC) are not well understood. Loss ICC is often associated with loss neuronal nitric oxide synthase (nNOS) in humans, suggesting a possible link. aim this study was to determine effect NO on mouse gastric body. volumes were determined nNOS(-/-) control mice body organotypic cultures using immunohistochemistry, laser scanning confocal microscopy three-dimensional reconstruction. numbers primary cell after...
Background: It has been reported that dexmedetomidine (DEX) can be used for conscious sedation in awake craniotomy, but few data exist to compare DEX versus propofol (PRO). Objective: To the efficacy and safety of PRO craniotomy. Methods: Thirty patients American Society Anesthesiologists grade I-II scheduled were randomized into 2 groups each containing 15 subjects. Group D received group P PRO. Two minutes after tracheal intubation (T1), (target plasma concentration) was titrated down 1 4...
This study was conducted to investigate the relationship between sperm DNA fragmentation index (DFI) and outcomes of in-vitro fertilisation-embryo transfer (IVF-ET) intracytoplasmic injection (ICSI). Sperm DFI in 116 patients for IVF 63 ICSI were detected with acridine orange test (AOT), all cases divided into ≤ 30% group > according value; then, IVF/ICSI analysed. Both cycles, good embryo rate spontaneous abortion significantly different from that group, meanwhile, fertilisation cleavage...
Hepatic steatosis is one of the most important features pathogenesis for non-alcoholic fatty liver disease. Fat deposition in cells can influence hepatic lipogenesis along with other metabolic pathways and further lead to irreversible cirrhosis injury. However, underlying mechanism remains largely unexplored. Our previous study revealed that AQP7 played an role steatosis. In this study, we determined transcriptional level was up-regulated by estrogen receptor alpha (ERα) upon 17β-estradiol...
Neuropeptide-FF (FLFQPQRF-NH2), originally isolated from bovine brain, is an FMRF-NH2-like peptide with morphine-modulating activity. (NPFF) unevenly distributed in the central nervous system, highest concentrations posterior pituitary and spinal cord. In rat pituitary, NPFF found exclusively neural lobe, where it localized nerve terminals fibers, indicating hypothalamus as a possible source of lobe NPFF. this study origin neurohypophyseal was investigated using various hypothalamic lesions...
Elevated fat mass and redistribution of body are commonly observed in postmenopausal women. Aquaporin 7 (AQP7), a unique glycerol permeable integral membrane protein, has been associated with the onset obesity. We hypothesized that estrogen supplementation could counteract this accumulation through tissue-specific modulation AQP7.We measured depot weight, adipocyte size, expression AQP7 kinase (GK) visceral subcutaneous tissues ovariectomized mice supplemented or without...
Objective: We previously reported that tissue-specific effects of estrogen on Aquaporin-7 (AQP7) expression are associated with the development menopausal obesity. The current study was designed to identify response elements (EREs) in promoter Aqp7 and investigate role AQP7 regulation estrogen-induced anti-adipogenesis. Methods: measured intracellular fat accumulation 3T3-L1 adipocytes either silenced shRNA or treated receptor (ER)-specific antagonists agonists before exposure estrogen. EREs...
// You Li 1, 3, * , Jing Zhu 2, Linfa Chen 2 Weidong Hu Mengxu Wang Shengnan 1 Xuefeng Gu Hua Tao Bin Zhao Guoda Ma and Keshen 3 Guangdong Key Laboratory of Age-Related Cardiac Cerebral Diseases, Affiliated Hospital Medical University, Zhanjiang 524001, China Department Neurology, Institute Zhanjiang, These authors have contributed equally to this work Correspondence to: Ma, email: sihan1107@126.com Li, keshenli1971@163.com Keywords: RAGE ; HMGB1 ischaemic stroke; gene variants; case-control...
Redistribution of adipose tissue in the abdomen during menopausal transition is attributable mostly to estrogen drop with aging. Adipose differentiation-related protein (ADRP), a major component lipid droplets, closely related onset accumulation. We hypothesized that exerted its tissue-specific effect reducing abdominal fat accumulation by regulation ADRP.Twenty-four female C57/BL6 mice aged 8 weeks were randomly divided into 3 groups: sham operation (Sham), bilateral ovariectomy (OVX), and...
We demonstrate that SCF-KIT signaling induces synthesis and secretion of endothelin-3 (ET3) in human umbilical vein endothelial cells melanoma vitro, gastrointestinal stromal tumors, sun-exposed skin, myenteric plexus colon post-fasting vivo. This is the first report a physiological mechanism ET3 induction. Integrating our finding with supporting data from literature leads us to discover previously unreported pathway nitric oxide (NO) generation derived NO synthase (eNOS) or neuronal NOS...
Eighty healthy male Wistar rats, aged 5 weeks, weighing 100-120 g, were utilized for establishing tumour-bearing models by immediate Walker-256 cancerous ascites injection and randomly divided to four groups (n=20) treated with 0.2 ml solution containing saline, (32)P-colloid (0.3 mCi), endostatin gene (20 μg), combined colloid (32)P. The effect of a small dose (32)P-colloidal on tumour growth in vivo was evaluated the potential mechanism underlying therapy explored. We found that exhibited...
Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disease in reproductive women associated with poor pregnancy outcomes. In modern society, people pay more attention to the female factor, but it uncertain whether sperm quality another factor affecting outcomes of patients PCOS. Method The effect DNA fragmentation (SDF) on oocyte fertilization, embryonic development, and for PCOS who underwent vitro fertilization (IVF) treatment was studied. A total 141 332 control...
Our aim was to study the efficacy and safety of tissue factor pathway inhibitor (TFPI)-coated stents in inhibiting restenosis a rabbit carotid artery model.Subculture conducted aorta smooth muscle cell, which taken from male Wistar rat, 3-5-generation cells were for plasmid transfection cytotoxicity experiment. TFPI microspheres made enwrapped by poly-l-glutamic acid (PLGA). TFPI-coated (n = 7) bare metal 6) implanted into prepared stenosis model New Zealand white rabbits. The efficiency...