A5100359459- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Reproductive biology and impacts on aquatic species
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Aquaculture Nutrition and Growth
- Genetic diversity and population structure
- Chromosomal and Genetic Variations
- Animal Genetics and Reproduction
- Congenital heart defects research
- Cardiomyopathy and Myosin Studies
- Autophagy in Disease and Therapy
- Plant and Fungal Species Descriptions
- Studies on Chitinases and Chitosanases
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomic variations and chromosomal abnormalities
- Sesquiterpenes and Asteraceae Studies
- Renin-Angiotensin System Studies
- Biological Control of Invasive Species
- COVID-19 Clinical Research Studies
- Acute Ischemic Stroke Management
- Marine Sponges and Natural Products
- Amyotrophic Lateral Sclerosis Research
- Zebrafish Biomedical Research Applications
Jilin Academy of Agricultural Sciences
2025
Ministry of Agriculture and Rural Affairs
2025
Jilin Province Science and Technology Department
2025
Hunan Normal University
2018-2025
Guangdong Medical College
2017-2023
Affiliated Hospital of Guangdong Medical College Hospital
2021-2023
Heilongjiang University
2023
Southern Medical University
2016-2022
Liaoning University of Traditional Chinese Medicine
2021
Jinan University
2020
// Zhi-Yan Hu 1, 2, 3, * , Xiao-Yan Wang Wen-bin Guo 4, 5, 6, Lin-Ying Xie 3 Yu-qi Huang 4 Yan-Ping Liu Li-Wei Xiao Sheng-Nan Li Hui-Fang Zhu Zu-Guo Heping Kan 1 Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China 2 School Basic Sciences, Guangdong Provincial Key Laboratory Molecular Tumour Hepatobiliary Surgery, 5 Urology, Sun Yat-sen Memorial 6 The Third Affiliated Hospital These authors contributed equally to this work Correspondence to: Kan, e-mail:...
Distant hybridization in fish typically involves the combination of genetic material from two distantly related species, creating new hybrids with substantial alterations both phenotypic traits and molecular genetics. In this study, we successfully produced a hybrid (BG) through intergeneric between blunt snout bream (Megalobrama amblycephala, BSB, 2n=48, ♀) green tip culter (Culter dabryi, GTC, ♂). We analyzed DNA content, chromosomal numbers, karyotypes, morphological traits, fertility, 5S...
Copy number variations (CNV) are important genetic variations. The endogenous factors cobalamin receptor (CUBN) and MIA SH3 domain ER-derived factor 3 (MIA3) associated with bone/muscle development intramuscular fat deposition. There have been no reports on the effects of CUBN MIA3 CNVs growth traits Chinese cattle. This study aimed to determine correlation between in qRT-PCR was used detect distribution CNV expression levels their mRNA, analysis conducted traits. differentially expressed...
Autism spectrum disorder (ASD) and dyslexia are both neurodevelopmental disorders with high prevalence in children. Both have strong genetic basis, share similar social communication deficits co-occurring impairments of reading or language. However, whether these two common risks remain elusive. DOCK4 (dedicator for cytokinesis 4), a guanine nucleotide exchange factor (GEF) the small GTPase Rac1, is one few genes that associated ASD dyslexia. Dock4 important neuronal development behaviors....
Circular RNAs (circRNAs) are a recently discovered noncoding RNA isoform capable of regulating neurological disease incidence. The present study was designed to characterize the circRNA expression profiles in large-artery atherosclerosis (LAA)-type acute ischemic stroke patients and detect biomarkers suitable for LAA-stroke detection. Using RNA-seq-based approach, we characterized five four controls. We confirmed differential target circRNAs through quantitative real-time polymerase chain...
The knowledge of understanding the molecular traits sterile triploid fish is sparse. Herein, we analyzed microRNA (miRNA) alternations in testes produced by crossing tetraploid with diploid fish, compared those tetraploids and diploids used as controls. A total 136, 134, 142 conserved miRNAs 105, 112, 119 novel were identified diploid, triploid, respectively. genes targeted differentially expressed enriched GO term cell surface receptor signaling pathway, cellular process, G-protein coupled...
Abstract Background Sperm abnormalities are one of the primary factors leading to male sterility, but their pathogenesis is still unclear. Although miRNAs suggested exert important roles in regulation spermatogenesis at both transcriptional and posttranscriptional levels, little currently known regarding sperm flagella assembly by microRNAs (miRNAs). The role development sterile triploid fish has not been studied. Results In this study, we found that miR-199-5p was widely expressed all...
Abstract Previous studies have suggested that microRNA‐186 (miR‐186) can be induced under hypoxic conditions, and is associated with apoptosis. This study was undertaken to explore the exact role of this microRNA (miRNA) in apoptotic death neurons during cerebral ischemic/reperfusion (I/R) injury. To model ischemia/reperfusion injuries, we utilized a transient middle artery occlusion approach rats, as well oxygen‐glucose deprivation/reoxygenation (OGD/R) Neuro2a cells. We found both vitro...
α-Glucan affects fungal cell-cell interactions and is important for the virulence of pathogenic fungi. Interfering with production α-glucan could help to prevent infection. In our previous study, we reported that an amylase-like protein, AmyD, repress accumulation in Aspergillus nidulans. However, underlying molecular mechanism was not clear. Here, examined localization AmyD found it a membrane-associated protein. We studied function degradation, as well other predicted proteins three...
Abstract Background Bleeker’s yellow tail ( Xenocypris davidi Bleeker, YT) and topmouth culter Culter alburnus Basilewsky, TC) are both famous important economic freshwater fish in China. YT, a kind of omnivorous fish, has strong resistance. TC, carnivorous high-quality meat but poor Distant hybridization can integrate the advantages parents. There been no previous report regarding hybrid derived from female YT × male TC. It is expected that these two kinds will result F 1 hybrids with...
Background. Age-related macular degeneration (AMD) is the leading cause of serious vision loss in elderly. Regulating microRNA (miRNA) gene expression offers exciting new avenues for treating AMD. This study aimed to investigate whether miRNAs and their target genes play an antiapoptotic role during oxidative stress-induced apoptosis retinal pigment epithelial (RPE) cells via mini-αA. Methods. ARPE-19 were treated with 3.5 mM NaIO3 48 h establish a model. Cells mini-αA (10, 15, 20 μM) 4 h....
The S100/calgranulin gene appears to modulate neuroinflammation following cerebral ischemia and could be a valuable biomarker for stroke prognosis, according growing research. This study aimed at evaluating the correlation between calgranulin variants susceptibility ischemic (IS) in Southern Chinese population. Using an enhanced multi-temperature ligase detection reaction genotyping, 310 IS patients 324 age-matched healthy controls were genotyped identify five variants. According obtained...
The miRNA-181 (miR-181) family regulates neuronal persistence during cerebral ischemia/reperfusion injury (CI/RI). Since the effect of miR-181d on CI/RI has never been studied, current work sought to determine involvement in apoptosis after brain I/R injury. To replicate vivo and vitro CI/RI, a transient middle artery occlusion (tMCAO) model rats an oxygen-glucose deficiency/reoxygenation (OGD/R) neuro 2A cells were developed. In both stroke models, expression was considerably higher....
The sterile triploid crucian carp (TC) has growth superiority which is generated from crossing between diploid red (Carassius carassius var. ♀) (RC) and tetraploid hybrid linage [derived RC (♀) × common (Cyprinus carpio, ♂) (CC)]. Hypothalamus an important control center for hormone releasing participating in gonadal development. In the present study, microRNA (miRNA) alternations hypothalamus RC, CC TC were analyzed. A total of 143 known miRNAs 519 novel identified hypothalamus. Thereinto,...
// You Li 1, 3, * , Jing Zhu 2, Linfa Chen 2 Weidong Hu Mengxu Wang Shengnan 1 Xuefeng Gu Hua Tao Bin Zhao Guoda Ma and Keshen 3 Guangdong Key Laboratory of Age-Related Cardiac Cerebral Diseases, Affiliated Hospital Medical University, Zhanjiang 524001, China Department Neurology, Institute Zhanjiang, These authors have contributed equally to this work Correspondence to: Ma, email: sihan1107@126.com Li, keshenli1971@163.com Keywords: RAGE ; HMGB1 ischaemic stroke; gene variants; case-control...
There is increasing evidence suggesting that dysregulation of miR-155 and its target angiotensin receptor type 1 (AT1R) are linked to the incidence ischemic stroke (IS), but underlying mechanisms remain be clarified. In this study, we therefore sought investigate how AT1R polymorphisms affect IS risk. We included 579 patients 509 age-matched controls in present analysis, genotyping individuals for rs767649 polymorphism miR-155, as well rs1492099 rs275653 via iMLDR-TM technology. The allele...
Emerging evidence suggests that the long noncoding RNA (lncRNA) growth arrest special 5 (GAS5) plays crucial roles in pathogenesis of ischemic stroke (IS). The current research is aimed at assessing correlation between two functional GAS5 variants (rs145204276 and rs55829688) susceptibility to IS a Han Chinese population. This study genotyped 1086 patients as well 1045 age-matched healthy controls by using an improved multitemperature ligase detection reaction (iMLDR-TM) genotyping...