You Li

ORCID: 0000-0003-1102-6268
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About
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Research Areas
  • Pharmacological Effects of Natural Compounds
  • Stroke Rehabilitation and Recovery
  • Pediatric Hepatobiliary Diseases and Treatments
  • Metabolomics and Mass Spectrometry Studies
  • Renin-Angiotensin System Studies
  • Cancer-related molecular mechanisms research
  • Liver Disease Diagnosis and Treatment
  • Catalytic Processes in Materials Science
  • Nanoporous metals and alloys
  • Medicinal Plants and Bioactive Compounds
  • Antibiotic Resistance in Bacteria
  • Antibiotics Pharmacokinetics and Efficacy
  • Inflammatory Bowel Disease
  • Acute Kidney Injury Research
  • Hemoglobin structure and function
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Telomeres, Telomerase, and Senescence
  • Immune cells in cancer
  • Galectins and Cancer Biology
  • Botulinum Toxin and Related Neurological Disorders
  • Magnesium Alloys: Properties and Applications
  • Brucella: diagnosis, epidemiology, treatment
  • Liver Diseases and Immunity
  • Digital Imaging in Medicine
  • Phytoestrogen effects and research

Yangtze University
2025

Sun Yat-sen University
2025

Third Hospital of Changsha
2022-2024

State Key Laboratory of Oncogene and Related Genes
2024

Renji Hospital
2019-2024

Shanghai Jiao Tong University
2019-2024

Chongqing Technology and Business University
2024

Guangdong Medical College
2021-2024

Yanbian University
2023

Dalian University
2021-2023

Circular RNAs (circRNAs) are a recently discovered noncoding RNA isoform capable of regulating neurological disease incidence. The present study was designed to characterize the circRNA expression profiles in large-artery atherosclerosis (LAA)-type acute ischemic stroke patients and detect biomarkers suitable for LAA-stroke detection. Using RNA-seq-based approach, we characterized five four controls. We confirmed differential target circRNAs through quantitative real-time polymerase chain...

10.1089/dna.2020.5662 article EN DNA and Cell Biology 2021-01-25

In recent years, functional electrical stimulation (FES) has become a common intervention for stroke survivors to correct foot drop and improve gait biomechanics. While the orthotic effects of adaptive FES systems were well-documented, center pressure (COP) symmetry been largely neglected. Furthermore, long-term therapeutic on biomechanics have received less attention. This study applied timing- intensity-adaptive system evaluation training tests address these limitations. test, eight...

10.1186/s12984-025-01577-0 article EN cc-by-nc-nd Journal of NeuroEngineering and Rehabilitation 2025-03-18

Ciliopathies such as cranioectodermal dysplasia, Sensenbrenner syndrome, short‐rib polydactyly, and Jeune syndrome are associated with respiratory complications arising from rib cage dysplasia. While ciliopathies have been demonstrated to involve primary cilia defects, we show motile dysfunction in the airway of a patient diagnosed this had mild thoracic dystrophy not requiring surgical treatment, there was nevertheless newborn distress, restrictive disease possible obstructive involvement,...

10.1002/ajmg.a.37133 article EN American Journal of Medical Genetics Part A 2015-04-25

A 64-year-old woman was admitted to the hospital for sudden weakness in one of her left limbs. The patient diagnosed with acute ischemic stroke (IS) undetermined cause and received intravenous thrombolysis. Following thrombolysis, patient’s limb improved, but she subsequently developed recurrent high fever delirium. Further diagnostic tests revealed that had been infected Brucella melitensis . showed significant improvement during anti-infection treatment Brucellosis secondary prevention IS....

10.3389/fimmu.2024.1347216 article EN cc-by Frontiers in Immunology 2024-03-12

Tumor necrosis factor superfamily protein 14 (TNFSF14) was recently identified as a risk in some fibrosis diseases. However, the role of TNFSF14 renal pathogenesis remains unknown.It found that levels were significantly increased both UUO-induced fibrotic mice and patients with nephropathy, compared those controls. Accordingly, Tnfsf14 deficiency led to marked reduction lesions inflammatory cytokines expression UUO mice. Furthermore, Sphk1, critical molecule causes remarkably reduced KO...

10.18632/aging.104151 article EN cc-by Aging 2020-11-21

A simple, sensitive and low-cost method using CE coupled with glucose-β-CD interaction assisted ACN stacking technique has been developed for quantification of trace amlodipine in dog plasma. The plasma samples were extracted methyl tert-butyl ether. separation was performed at 25°C a 31.2 cm × 75 μm fused-silica capillary an applied voltage 15 kV. BGE composed 6.25 mM borate/25 phosphate (pH 2.5) 5 mg/mL glucose-β-CD. detection wavelength 200 nm. Because CD could diminish the between drugs...

10.1002/jssc.201201044 article EN Journal of Separation Science 2013-03-14

Bacterial biofilms, often forming on medical devices, can lead to treatment failure due their increased antimicrobial resistance. Cefepime-avibactam (CFP-AVI) exhibits potent activities against Pseudomonas aeruginosa (P. aeruginosa) and Klebsiella pneumoniae (K. pneumoniae) when used with polymyxin B (PMB). However, its efficacy in biofilm-related infections is unknown. The present study aimed evaluate the activity of PMB combined CFP-AVI biofilms PMB-resistant Gram-negative bacteria. Five...

10.1186/s12866-024-03571-3 article EN cc-by-nc-nd BMC Microbiology 2024-10-16

Abnormal Savda Munziq (ASMq) is a traditional Uyghur herbal preparation used as therapy for abnormal Savda-related diseases. In this study, we investigate ASMq's dynamic effects on rat models under different disease conditions.Abnormal with hepatocellular carcinoma (HCC), type 2 diabetes mellitus (T2DM), and asthma dosed of ASMq. Serum samples each animal tested by nuclear magnetic resonance spectroscopy analyzed orthogonal projection to latent structure discriminant analysis.Compared...

10.4103/0973-1296.165551 article EN Pharmacognosy Magazine 2015-01-01

To investigate the expression of neuroglobin (Ngb) in retina rats with ocular hypertension induced acute retinal hypoxic-ischemic injury.Seventy Wistar were divided into 7 groups randomly. The experimental model was by elevation intraocular pressure via anterior chamber canula insertion left eyes and fellow preserved as normal controls. tissues taken at 1, 5, 10, 15, 20, 30 60 minutes after hypoxic-ischemia injury. Protein extracted, then analyzed Western-blot method. SPSS used for...

10.3980/j.issn.2222-3959.2011.04.14 article EN PubMed 2011-01-01

The aim of this study was to determine the metabolic biomarkers for abnormal Savda syndrome in patients with chronic obstructive pulmonary disease (COPD). Based on Traditional Uyghur Medicine (TUM) theory, a total 103 COPD were classified into and non-abnormal groups 52 healthy volunteers acted as control group. Blood samples from three analyzed using nuclear magnetic resonance (NMR) spectroscopy combined orthogonal projection latent structure-discriminant analysis. NMR tests showed that...

10.3892/etm.2014.2085 article EN Experimental and Therapeutic Medicine 2014-11-24

Cardioembolic stroke, characterized by severe illness, poor prognosis, and high recurrence rate, is one of the important causes ischemic stroke. In field genetic research, numerous genes associated with cardioembolic stroke have been identified, their potential in predicting disease risk evaluating factors has progressively explored. Here, we provide an overview latest advancements genetics for including genome-wide association studies, copy number variation whole-genome sequencing studies....

10.16288/j.yczz.23-282 article EN PubMed 2024-05-20
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