A5103212581- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Prostate Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- bioluminescence and chemiluminescence research
- Prostate Cancer Treatment and Research
- Marine Bivalve and Aquaculture Studies
- S100 Proteins and Annexins
- Alzheimer's disease research and treatments
- Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Algal biology and biofuel production
- Amyotrophic Lateral Sclerosis Research
- Advanced X-ray and CT Imaging
- Physiological and biochemical adaptations
- Cardiomyopathy and Myosin Studies
- Renin-Angiotensin System Studies
- Urologic and reproductive health conditions
- Autophagy in Disease and Therapy
- RNA regulation and disease
- MRI in cancer diagnosis
- Environmental Toxicology and Ecotoxicology
- Marine Biology and Environmental Chemistry
Hainan University
2023-2025
Guangdong Medical College
2019-2023
Xi'an University of Science and Technology
2022
NYU Langone Health
2013-2014
Capital Medical University
1996
Circular RNAs (circRNAs) are a recently discovered noncoding RNA isoform capable of regulating neurological disease incidence. The present study was designed to characterize the circRNA expression profiles in large-artery atherosclerosis (LAA)-type acute ischemic stroke patients and detect biomarkers suitable for LAA-stroke detection. Using RNA-seq-based approach, we characterized five four controls. We confirmed differential target circRNAs through quantitative real-time polymerase chain...
Abstract Previous studies have suggested that microRNA‐186 (miR‐186) can be induced under hypoxic conditions, and is associated with apoptosis. This study was undertaken to explore the exact role of this microRNA (miRNA) in apoptotic death neurons during cerebral ischemic/reperfusion (I/R) injury. To model ischemia/reperfusion injuries, we utilized a transient middle artery occlusion approach rats, as well oxygen‐glucose deprivation/reoxygenation (OGD/R) Neuro2a cells. We found both vitro...
The S100/calgranulin gene appears to modulate neuroinflammation following cerebral ischemia and could be a valuable biomarker for stroke prognosis, according growing research. This study aimed at evaluating the correlation between calgranulin variants susceptibility ischemic (IS) in Southern Chinese population. Using an enhanced multi-temperature ligase detection reaction genotyping, 310 IS patients 324 age-matched healthy controls were genotyped identify five variants. According obtained...
The miRNA-181 (miR-181) family regulates neuronal persistence during cerebral ischemia/reperfusion injury (CI/RI). Since the effect of miR-181d on CI/RI has never been studied, current work sought to determine involvement in apoptosis after brain I/R injury. To replicate vivo and vitro CI/RI, a transient middle artery occlusion (tMCAO) model rats an oxygen-glucose deficiency/reoxygenation (OGD/R) neuro 2A cells were developed. In both stroke models, expression was considerably higher....
There is increasing evidence suggesting that dysregulation of miR-155 and its target angiotensin receptor type 1 (AT1R) are linked to the incidence ischemic stroke (IS), but underlying mechanisms remain be clarified. In this study, we therefore sought investigate how AT1R polymorphisms affect IS risk. We included 579 patients 509 age-matched controls in present analysis, genotyping individuals for rs767649 polymorphism miR-155, as well rs1492099 rs275653 via iMLDR-TM technology. The allele...
Emerging evidence suggests that the long noncoding RNA (lncRNA) growth arrest special 5 (GAS5) plays crucial roles in pathogenesis of ischemic stroke (IS). The current research is aimed at assessing correlation between two functional GAS5 variants (rs145204276 and rs55829688) susceptibility to IS a Han Chinese population. This study genotyped 1086 patients as well 1045 age-matched healthy controls by using an improved multitemperature ligase detection reaction (iMLDR-TM) genotyping...
Large-scale genome-wide association analyses show an between ADAMTS7 variations and coronary risk.However, the link variability ischaemic stroke (IS) has yet to be determined.This study evaluated variants with respect risk of IS.Genetic were performed in two independent case-control cohorts 1279 patients IS 1268 age-matched healthy controls.Four variant genotypes gene identified using Multiplex SNaPshot assay.The rs3825807, rs11634042, rs7173743 related lower both initial replication...