A5100757944- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Circular RNAs in diseases
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
- Gene expression and cancer classification
- Cell Image Analysis Techniques
- Computational Drug Discovery Methods
- AI in cancer detection
- Neuropeptides and Animal Physiology
- Pharmacological Effects of Natural Compounds
- Advanced Biosensing Techniques and Applications
- Advanced Breast Cancer Therapies
- Histone Deacetylase Inhibitors Research
- Organ Transplantation Techniques and Outcomes
- Cervical Cancer and HPV Research
- T-cell and B-cell Immunology
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Burn Injury Management and Outcomes
- Pain Mechanisms and Treatments
- HER2/EGFR in Cancer Research
First Affiliated Hospital of Xinjiang Medical University
2019-2025
Xinjiang Medical University
2019-2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2025
Seoul National University
2025
Changsha Medical University
2021-2024
University of California, Los Angeles
2024
California NanoSystems Institute
2024
ZheJiang Academy of Agricultural Sciences
2024
Zhejiang Wanli University
2024
A simple and rapid method for the analysis of genetic polymorphisms has been developed using allele-specific oligonucleotide arrays bound to glass supports. Allele-speciflc ollgonucleotides are covalently immobilized on slides in 3 mm spots. Genomlc DNA is amplified by PCR one fluorescently tagged primer biotinylated oligonucleotide. The two complementary strands separated, strand Is hybridized support-bound array, hybridization pattern detected fluorescence scanning. Multiple present...
Journal Article Differential display using one-base anchored oligo-dT primers Get access Peng Liang, Liang * 1Division of Cell Growth and Regulation, Dana-Farber Cancer InstituteBoston, MA 021152GenHunter CorporationBrookline, 02146, USA *To whom correspondence should be addressed at: Division Institute, Boston, 02115, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar Weimin Zhu, Zhu 02115 Xiaoying Zhang, Zhang 2GenHunter Zhen Guo, Guo Robert P.O....
How bipotential hepatoblasts differentiate into hepatocytes and cholangiocytes remains unclear. Here, using single-cell transcriptomic analysis of hepatoblasts, hepatocytes, sorted from embryonic day 10.5 (E10.5) to E17.5 mouse embryos, we found that hepatoblast-to-hepatocyte differentiation occurred gradually followed a linear default pathway. As more cells became fully differentiated the number proliferating decreased. Surprisingly, quiescent exhibited homogeneous states at given...
Cancer stem cells (CSCs) play a vital role in tumor initiation, progression, metastasis, chemoresistance, and recurrence. The mechanisms that maintain the stemness of these remain largely unknown. Our previous study indicated MALAT-1 may serve as an oncogenic long noncoding RNA pancreatic cancer by promoting epithelial-mesenchymal transition (EMT) regulating CSCs markers expression. More significantly, there is emerging evidence EMT process give rise to CSCs, or at least with cell-like...
Current criteria for the selection of unrelated donors hematopoietic cell transplantation (HCT) include matching alleles each human leukocyte antigen (HLA) locus within major histocompatibility complex (MHC). Graft-versus-host disease (GVHD), however, remains a significant and potentially life-threatening complication even after HLA-identical HCT. The MHC harbors more than 400 genes, but total number antigens is unknown. Genes that influence outcome could be identified by using linkage...
Abstract Radioresistance is the main obstacle in clinical management of nasopharyngeal carcinoma (NPC). linc00312 deregulated a number human cancers, including NPC. However, detailed functions and underlying mechanisms regulating radiosensitivity NPC remains unknown. In this study, cox regression analysis was used to assess association between patients’ survival after radiotherapy. Our results reveal that significantly down-regulated tissues patients with higher expression are associated...
Abstract Nasopharyngeal carcinoma (NPC) is a common head and neck malignant with high incidence in Southern China. Genetic aberrations play vital role the pathogenesis, progression prognosis of NPC. In present study, we elucidated underlying mechanism FAS-AS1 its genetic variation rs6586163 We demonstrated that variant genotype carriers were associated lower risk NPC (CC vs. AA, OR = 0.645, P 0.006) better overall survival (AC + CC HR 0.667, 0.030). Mechanically, increased transcriptional...
Nasopharyngeal carcinoma (NPC) is a cancer with high metastatic rate and poor prognosis. Growing studies suggest that ferroptosis take part in the development of tumours. At same time, connection between ferroptosis-related genes (FRGs) prognosis NPC remains unclear. In this study, we explored dysregulated FRGs normal control tumour samples NPC. Firstly, 14 36 differentially expressed were identified tissues compared to tissues, among which ABCC1, GLS2, CS HMGCR associated for patients. The...
The olfactory epithelium maintains stem and progenitor cells that support the neuroepithelium's life-long capacity to reconstitute after injury. However, identity of cells--and their regulation--remain poorly defined. transcription factors Pax6 Sox2 are characteristic in many tissues, including brain. Therefore, we assessed expression normal during epithelial regeneration methyl bromide lesion or bulbectomy. is found multiple kinds epithelium, sustentacular cells, horizontal basal some...
Allicin (AL) is one of garlic-derived organosulfides and has a variety pharmacological effects. Studies have reported that AL notable inhibitory effects on liver cancer, gastric breast other cancers. However, there are no relevant reports about its role in human nasopharyngeal carcinoma. Ferroptosis an iron-dependent form non-apoptotic regulated cell death. Increasing evidence indicates induction ferroptosis can inhibit the proliferation, migration, invasion, survival various cancer cells,...
Human epidermal growth factor receptor 2 (HER2) is a critical protein in cancer cell that signifies the aggressiveness of breast (BC) and helps predict its prognosis. Accurate assessment immunohistochemically (IHC) stained tissue slides for HER2 expression levels essential both treatment guidance understanding mechanisms. Nevertheless, traditional workflow manual examination by board-certified pathologists encounters challenges, including inter- intra-observer inconsistency extended...
Despite great progress, the current cancer treatments often have obvious toxicity and side effects. a poor prognosis (some patients). One of reasons for is that certain enzymes prevent anticancer drugs from killing tumor cells. AKT1 involved in regulating PI3K/AKT/mTOR, tumor-generating pathway. Ipatasertib, highly selective inhibitor AKT1, widely used treatment tumors. In this study, many structural biochemical methodswere to find better AKT1(Threonine Kinase 1) inhibitors, which laid...
Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide. However, present studies of its multiple gene interaction and cellular pathways still could not explain initiation development HCC perfectly. To find key genes miRNAs as well their potential molecular mechanisms in HCC, microarray data GSE22058, GSE25097, GSE57958 were analyzed.The datasets GSE57958, including mRNA miRNA profiles, downloaded from GEO database analyzed using GEO2R. Functional pathway enrichment...
Cisplatin (CDDP) nephrotoxicity is one of the most common side effects in cancer treatment, causing disruption chemotherapy. In this study, we analyzed influence nongenetic factors on CDDP-induced nephrotoxiciy using data from 182 CDDP-treated and 52 carboplatin (CBP)-treated patients. The mean change eGFR (100% to baseline) patients was -9.2%, which significantly lower than that population with CBP therapy. By chi-squared test multivariate logistic regression analysis, age (≥50 years) found...
Crocin, the main effective component of saffron, exerts protective effects against ischemia/reperfusion injury during strokes. However, crocin in myocardial injury, and mechanisms involved, remain unknown. Pretreated with for 7 days, C57BL/6N mice were subjected to 30 min ischemia followed by 12[Formula: see text]h reperfusion (for cardiac function infarct size, cell apoptosis necrosis). Neonatal mouse cardiomyocytes 2 h hypoxia 4 reoxygenation. NMCM’s survival was assessed reoxygenation...