A5019249919- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Physiological and biochemical adaptations
- Neurological Disease Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Photoreceptor and optogenetics research
- Ocular Surface and Contact Lens
- Healthcare and Venom Research
- interferon and immune responses
- Corneal Surgery and Treatments
- Barrier Structure and Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Ocular Infections and Treatments
- Retinal Development and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- CRISPR and Genetic Engineering
- Prostate Cancer Treatment and Research
- Plant responses to water stress
- Cellular transport and secretion
- Wound Healing and Treatments
- Bioactive Compounds and Antitumor Agents
- Chemokine receptors and signaling
- Ginger and Zingiberaceae research
Foundation Medicine (United States)
2021-2025
Huzhou Central Hospital
2024
Zhejiang Chinese Medical University
2024
Huzhou University
2024
Chengdu University of Traditional Chinese Medicine
2024
Stanford University
2018-2022
Nanjing University of Chinese Medicine
2022
Dalian Medical University
2020
First Affiliated Hospital of Dalian Medical University
2020
Institute of Behavioral Sciences
2018
Homeostatic synaptic plasticity is a mechanism through which the nervous system adjusts excitation and inhibition to maintain network stability. Retinoic acid (RA) its receptor RARα have been established as critical mediators of homeostatic plasticity. In vitro studies reveal that RA signaling enhances excitatory strength decreases inhibitory strength. However, it unclear whether RA-mediated occurs in vivo , if so, operates at specific types synapses. Here, we examine impact RA/RARα...
195 Background: Mechanisms of resistance to agents targeting the androgen receptor (AR) axis in prostate cancer (PC) include AR amplification (AMP), ligand-binding domain mutations (MUT), and splice variants (AR-Vs), such as AR-V7, which has been associated with signaling inhibitors (ARSi) abiraterone enzalutamide castration resistant PC (CRPC). Clinically employed AR-V7 assays involve detection circulating tumor cells (CTCs) based on either nuclear protein immunofluorescent staining or RNA...
Crocin, the main effective component of saffron, exerts protective effects against ischemia/reperfusion injury during strokes. However, crocin in myocardial injury, and mechanisms involved, remain unknown. Pretreated with for 7 days, C57BL/6N mice were subjected to 30 min ischemia followed by 12[Formula: see text]h reperfusion (for cardiac function infarct size, cell apoptosis necrosis). Neonatal mouse cardiomyocytes 2 h hypoxia 4 reoxygenation. NMCM’s survival was assessed reoxygenation...
Traditional Chinese herbal (TCH) medicines have emerged as a prospective and affordable method to treat various diseases with broad range of biological activity; however, traditional preparations, like decoctions, are often associated low bioavailability, thus resulting in limited efficacy against cancer. The drawbacks active TCH components, including instability, poor permeability, high hydrophilicity or hydrophobicity, undesirable pharmacokinetic profiles, off-target toxicity, also exist....
Abstract Nitric oxide (NO) has been shown to regulate neuronal excitability in the nervous system, but little is known as whether NO, which synthesized certain neurons, also serves functional roles within NO‐producing neurons themselves. We investigated this possibility by using a nitric synthase (NOS)‐expressing neuron, and studied role of intrinsic NO production on firing properties single‐cell culture. B5 pond snail Helisoma trivolvis fire spontaneous action potentials (APs), once...
Reducing long length of stay (LLOS, or inpatient stays lasting over 30 days) is an important way for hospitals to improve cost efficiency, bed availability and health outcomes. Discharge delays can hundreds thousands dollars per patient, LLOS represents a burden on other potential patients. However, most research studies investigating discharge barriers are not LLOS-specific. Of those that do, nearly all limited by further patient subpopulation focus small sample size. To our knowledge,...
Nitric oxide (NO) is an unconventional membrane-permeable messenger molecule that has been shown to play various roles in the nervous system. How NO modulates ion channels affect neuronal functions not well understood. In gastropods, implicated regulating feeding motor program. The buccal motoneuron, B19, of freshwater pond snail Helisoma trivolvis active during hyper-retraction phase program and located vicinity NO-producing neurons ganglion. Here, we asked whether B19 might serve as direct...
Nitric oxide (NO) is a radical and gas, properties that allow NO to diffuse through membranes potentially enable it function as “volume messenger.” This study had two goals: first, investigate the mechanisms by which functions modulator of neuronal excitability, second, compare effects produced release from chemical donors with those elicited physiological single neurons. We demonstrate depolarizes membrane potential B5 neurons mollusk Helisoma trivolvis , initially increasing their firing...
In addition to acting as a classical neurotransmitter in synaptic transmission, acetylcholine (ACh) has been shown play role axonal growth and cone guidance. What is not well understood how ACh acts on cones affect filopodia, structures known be important for neuronal pathfinding. We addressed this question using an identified neuron (B5) from the buccal ganglion of pond snail Helisoma trivolvis cell culture. treatment caused pronounced filopodial elongation within minutes, effect that...
Contact lens safety is an important topic in clinical studies. Corneal infections usually occur because of the use bacteria-carrying contact lenses. The current study investigated impact plasma surface modification on bacterial adherence to rigid lenses made fluorosilicone acrylate materials.Boston XO and XO2 were modified using technology (XO-P XO2-P groups). Untreated used as controls. Plasma-treated control incubated solutions containing Staphylococcus aureus or Pseudomonas aeruginosa....
Auditory evoked potential (AEP) is an effective index for the effects of general anesthetics. However, it's unknown if AEP can differentiate anesthetics on nerve fibers and synapses. Presently, we investigated latency amplitude changes to different acoustic intensities during pentobarbital anesthesia. Latency more regularly changed than monotonically decreased with intensity increase (i.e., latency-intensity curve) could be fitted exponential decay equation, which showed two components,...
Abstract Nitric oxide ( NO ) is a key regulator of neuronal excitability in the nervous system. While most studies have investigated its role as an intercellular messenger/modulator, less known about potential physiological roles played by within ‐producing neurons. We showed previously that intrinsic production B5 neurons pond snail Helisoma trivolvis increased acting on three ionic conductances. Here we demonstrate intrinsically produced affected two same conductances another buccal...
ABSTRACT The electrical activity in developing and mature neurons determines the intracellular calcium concentration ([Ca 2+ ] i ), which turn is translated into biochemical activities through various signaling cascades. Electrical under control of neuromodulators, can alter neuronal responses to incoming signals increase fidelity communication. Conversely, effects neuromodulators depend on ongoing within target neurons; however, these activity‐dependent are less well understood. Here, we...
Adeno-associated viruses (AAVs) targeting specific cell types are powerful tools for studying distinct in the central nervous system (CNS). Cis-regulatory modules (CRMs), e.g., enhancers, highly cell-type-specific and can be integrated into AAVs to render type specificity. Chromatin accessibility has been commonly used nominate CRMs, which have then incorporated tested specificity CNS. However, chromatin data alone cannot accurately annotate active as many chromatin-accessible CRMs not fail...
Background Wearing contaclenincreasethe risk of infection the cornea.Some studieshowed gas-permeability materialused foconstructing corneal contaclenione contributing factorrelated to health.Objective Thistudy wato observe in vitro adherence ability differenbacterito rigid gas-permeable contaclense(RGP-CL) made with varioumaterials.MethodContaclensemade hexafocon,enflufocon opolymethyl methacrylate (PMMA) were placed into...
Studies have found that a large number of inflammatory cells, P-selectin, and mature dendritic cells (DCs) are expressed in the damaged shoulder parts atherosclerotic plaque, which demonstrates P-selectin DCs participate immune response leading to development atherosclerosis. However, it is unclear how above factors interact this setting. In study, we investigated role its receptor, glycoprotein ligand (PSGL)-1 atherosclerosis, with finding DC surface marker expression was consistently high...
Many actions of acetylcholine (ACh) are mediated by cation‐selective nicotinic ACh receptors (nAChRs). Our lab found that activates nAChRs to elongate growth cone filopodia on B5 neurons from the pond snail Helisoma trivolvis in vitro . Interestingly, pharmacological evidence revealed existence anion‐selective B19 neurons, mediating inhibitory cholinergic responses. Unfortunately, little is known about molecular nature these two distinct Using a transcriptome database, we putative nAChR...