A5111527336- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Multiple and Secondary Primary Cancers
- Tryptophan and brain disorders
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- COVID-19 and healthcare impacts
- Sinusitis and nasal conditions
- Urologic and reproductive health conditions
- Homicide, Infanticide, and Child Abuse
- MRI in cancer diagnosis
- S100 Proteins and Annexins
- Cancer, Stress, Anesthesia, and Immune Response
- Esophageal Cancer Research and Treatment
- Cancer and Skin Lesions
- Advanced MRI Techniques and Applications
- Head and Neck Anomalies
- COVID-19 and Mental Health
- Lung Cancer Treatments and Mutations
- Mindfulness and Compassion Interventions
- Cardiovascular Effects of Exercise
- Fibroblast Growth Factor Research
- Digital Mental Health Interventions
Cleveland Clinic
2022-2025
Prince Charles Hospital
2023
University of Minnesota Medical Center
2016-2020
Command Hospital
2020
West Bengal University of Health Sciences
2020
B.J. Medical College
2016
University of Minnesota
2015
Hindu Rao Hospital
2010-2015
Moffitt Cancer Center
2014
Bronx-Lebanon Hospital Center
2005
439 Background: Cisplatin-based neoadjuvant chemotherapy (NAC) in MIBC improves survival which correlates with pathologic response (PaR) at radical cystectomy (RC). The combination of immunotherapy and NAC may improve PaR outcomes MIBC. We tested the efficacy safety nivolumab (N) gemcitabine-cisplatin (GC) as therapy for our phase II trial (NCT03294304). Methods: Eligible pts (cT2-T4a, N≤1, M0) who were candidates RC enrolled. Pts received C (70mg/m2) IV on D1, G (1000mg/m2) D1,D8 N (360 mg)...
The behavior of intra-abdominal desmoids in familial adenomatous polyposis is incompletely understood. Findings range from typical mass lesions to flat sheets, termed the desmoid reaction or precursor lesion. latter often are incidental findings uncertain significance. study was designed describe natural history tumors with particular reference reaction.Patients who underwent laparotomy for at Cleveland Clinic Foundation were identified. incidence determined by review operative records....
845 Background: CAUBC (metastatic and surgically incurable advanced UBC) is a challenging with significant need for improvement in systemic therapies. We aimed to explore HRD sig status related biomarkers, including other GA, generate hypothesis inform clinical trial designs these patients. Methods: 8825 cases of underwent comprehensive genomic profiling (CGP) examine all classes alterations (GA). MSI high status, tumor mutation burden (TMB) levels, ancestry trinucleotide mutational...
824 Background: CAPSCC is a challenging disease with significant need for improvements in effective systemic therapies patients surgically incurable disease. Methods: 373 cases of underwent comprehensive genomic profiling to examine all classes alterations (GA). MSI high status, tumor mutation burden (TMB) levels, ancestry and trinucleotide mutational signatures were determined from the sequencing data. HRDsig status was calculated using broad set genome-wide copy number features (PMID...
TPS893 Background: It is hypothesized that V940 (mRNA-4157), an individualized neoantigen therapy consisting of mRNA encoding up to 34 tumor neoantigens, will work in synergy with immune checkpoint inhibitors by generating de novo tumor-specific T-cell activity. In a phase 2 trial patients high-risk melanoma, adjuvant + pembrolizumab had manageable safety profile and improved recurrence-free distant metastasis–free survival versus monotherapy. The 1/2 INTerpath-005 study (NCT06305767) has...
195 Background: Mechanisms of resistance to agents targeting the androgen receptor (AR) axis in prostate cancer (PC) include AR amplification (AMP), ligand-binding domain mutations (MUT), and splice variants (AR-Vs), such as AR-V7, which has been associated with signaling inhibitors (ARSi) abiraterone enzalutamide castration resistant PC (CRPC). Clinically employed AR-V7 assays involve detection circulating tumor cells (CTCs) based on either nuclear protein immunofluorescent staining or RNA...
3066 Background: The indoleamine 2,3-dioxygenase (IDO) pathway is a key counter-regulatory mechanism exploited by tumors in order to prevent and defeat anti-tumor immunity. Sipuleucel-T has overcome this tumor mediated anergy only part its ex-vivo sensitization. Small-molecule inhibitors of the IDO pathway, such as indoximod, are an increasingly validated class potential cancer therapeutics. We tested hypothesis whether targeting indoximod will inhibit Treg abrogate tumor-mediated...
4504 Background: Platinum-based chemotherapy for 1st-line treatment of pts with metastatic urothelial cancer (mUC) is typically administered a fixed duration followed by observation until recurrence. PD-1 blockade pembro improves survival mUC progressing despite platinum-based chemotherapy. We explored the potential benefit earlier use using "switch maintenance" approach. Methods: Pts achieving at least stable disease after up to 8 cycles were enrolled. randomized 1:1 200 mg IV q3 weeks...
LBA110 Background: There are limited data on COVID-19 in patients with cancer. We characterize the outcomes of cancer and identify potential prognostic factors. Methods: The Cancer Consortium (CCC19) cohort study includes active or prior hematologic invasive solid malignancies reported across academic community sites. Results: included 1,018 cases accrued March-April 2020. Median age was 66 years (range, 18-90). Breast (20%) prostate (16%) cancers were most prevalent; 43% anti-cancer...
Abstract Solitary neurofibroma of the scrotum is exceedingly rare and very few cases this unusual occurrance have been reported till date. None previously had a preoperative cytologic diagnosis. A young man presented with an eight‐month history right scrotal swelling. Fine‐needle aspiration cytology showed spindle cell tumor fibrillary matrix wavy slender nuclei. diagnosis benign nerve sheath was rendered. The patient underwent surgical excision mass histopathologic examination confirmed...
We report a case of child with Pott's puffy tumor (PPT) in which ultrasonography contributed to making the diagnosis. The clinical presentation and laboratory investigations were inconclusive, diagnosis PPT was made by subsequently confirms CT scan MRI. © 2005 Wiley Periodicals, Inc. J Clin Ultrasound 33:305–307,
Background: The objective was to assess the efficacy and safety of pretreatment with Mifepristone in induction late intrauterine fetal death combination misoprostol.Methods: A prospective study carried out GMERS Medical College, Sola, Ahmedabad between October 2014 April 2016. Data from 72 women gestational age 24 42 weeks were analyzed. Group received single oral dose 200 mg followed 36 48 hours later Misoprostol (200-50 microgram) every 4 hour a maximum 5 doses. first kept vaginally...
An investigator-initiated, Australia-wide multi-centre retrospective observational study was undertaken to investigate the real-world prevalence of programmed death ligand-1 (PD-L1) expression in non-small cell lung carcinoma (NSCLC). Multiple centres around Australia performing PD-L1 immunohistochemistry (IHC) were invited participate. Histologically confirmed NSCLC any stage with a IHC test performed for persons aged ≥18 years between 1 January 2018 and 2020, eligible review, identified at...
TPS4587 Background: Immuno-oncology (IO) therapies have revolutionized the treatment (tx) of pts with advanced bladder cancer (advBC). For cisplatin-eligible MIBC, recommended tx regimen is cisplatin-based NAC prior to radical cystectomy (RC). However, since only ≈ 30% achieve a pathologic complete response (pCR) translating improved long-term outcomes approved regimens, new are needed. PD-L1 expression associated aggressive BC and has been shown increase in after NAC, suggesting that...
TPS3095 Background: Toll-like receptors (TLRs) are proteins in the innate immune system that, once bound to their ligands, directly activate cells, including myeloid dendritic plasmacytoid monocytes/macrophages, and B cells. This activation may result modulation such as of co-stimulatory molecules, production antitumor antiviral cytokines, stimulation cell-mediated NK T cell responses involved eradicating tumors. MEDI9197 is a small molecule imidazoquinoline agonist for human TLR7 TLR8 that...