David D. Chism
A5079604596- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- COVID-19 and healthcare impacts
- Economic and Financial Impacts of Cancer
- Advanced Breast Cancer Therapies
- COVID-19 Clinical Research Studies
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Healthcare cost, quality, practices
- Melanoma and MAPK Pathways
- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Global Cancer Incidence and Screening
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
Thompson Cancer Survival Center
2021-2025
Vanderbilt University Medical Center
2016-2019
Breast Cancer Research Foundation
2019
Vanderbilt-Ingram Cancer Center
2019
Vanderbilt University
2017-2018
Karyopharm Therapeutics (United States)
2017
Exelixis (United States)
2017
UNC Lineberger Comprehensive Cancer Center
2013-2015
University of North Carolina at Chapel Hill
2014-2015
St. Jude Children's Research Hospital
2006
Significance The identification of molecular subtype heterogeneity in breast cancer has allowed a deeper understanding biology. We present evidence that there are two intrinsic subtypes high-grade bladder cancer, basal-like and luminal, which reflect the hallmarks Moreover, we have developed an accurate gene set predictor subtype, BASE47, should allow incorporation stratification into clinical trials. Further clinical, etiologic, therapeutic response associations will be interest future...
Testicular cancer is relatively uncommon and accounts for <1% of all male tumors. However, it the most common solid tumor in men between ages 20 34 years, global incidence has been steadily rising over past several decades. Several risk factors testicular have identified, including personal or family history cryptorchidism. germ cell tumors (GCTs) comprise 95% malignant arising testes are categorized into 2 main histologic subtypes: seminoma nonseminoma. Although nonseminoma more clinically...
Patients with cancer may be at high risk of adverse outcomes from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We analyzed a cohort patients and 2019 (COVID-19) reported to the COVID-19 Cancer Consortium (CCC19) identify prognostic clinical factors, including laboratory measurements anticancer therapies. active or historical laboratory-confirmed SARS-CoV-2 diagnosis recorded between 17 March 18 November 2020 were included. The primary outcome was severity measured...
Data supporting neoadjuvant chemotherapy of high grade upper tract urothelial carcinoma are scant. In this multi-institution, prospective, phase II trial we investigated pathological complete responses after carcinoma.Patients with in whom nephroureterectomy was planned were assigned to 4 cycles accelerated methotrexate, vinblastine, doxorubicin and cisplatin those baseline creatinine clearance greater than 50 ml per minute or gemcitabine carboplatin 30 less. The study primary end point a...
<h3>Importance</h3> Non-Hispanic Black individuals experience a higher burden of COVID-19 than the general population; hence, there is an urgent need to characterize unique clinical course and outcomes in patients with cancer. <h3>Objective</h3> To investigate racial disparities severity presentation, complications, between non-Hispanic White cancer COVID-19. <h3>Design, Setting, Participants</h3> This retrospective cohort study used data from Cancer Consortium registry March 17, 2020,...
Human airway smooth muscle (HASM) cells express interleukin (IL)-13 and IL-4 receptors respond to these cytokines with signal transducer activator of transcription-6 extracellular signal-regulated kinase (ERK) activation. The purpose this study was determine whether IL-13 and/or influence eotaxin release in HASM the ERK mitogen-activated protein (MAP) pathway is involved events. Eotaxin into cell supernatants assayed by ELISA, mRNA expression determined Northern blot analysis. Pretreatment...
Abstract The peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear family that forms heterodimers with retinoid X receptor. These bind to DNA and activate transcription target genes. Here, we report PPARγ protein expressed in primary myeloid lymphoid leukemias lymphoma myeloma cell lines. In this study, compared activity several ligands including BRL49653 (rosiglitazone), 15-deoxy-Δ12,14-prostaglandin J2, novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic...
4504 Background: Combining an immune checkpoint inhibitor with a targeted antiangiogenic agent may leverage complementary mechanisms of action for treatment aRCC. Avelumab is fully human anti–PD-L1 IgG1 antibody clinical activity in various tumor types; axitinib, VEGF receptor inhibitor, approved second-line JAVELIN Renal 100 (NCT02493751) phase Ib study evaluating safety and avelumab + axitinib treatment-naïve pts aRCC; updated results are reported here. Methods: Eligible had confirmed...
The majority of urothelial cancers (UC) harbor alterations in retinoblastoma (Rb) pathway genes that can lead to loss Rb tumour suppressor function. Palbociclib is an oral, selective inhibitor CDK 4/6 restores function and promotes cell cycle arrest. In this phase II trial, patients with metastatic platinum-refractory UC molecularly selected for p16 intact by immunohistochemistry received palbociclib 125 mg p.o. daily 21 days a 28-day cycle. Primary endpoint was progression-free survival at...
<title>Abstract</title> Colorectal cancer (CRC) is the 2nd leading cause of death in United States (US). Rural Appalachia suffers highest CRC incidence and mortality rates. There are several non-clinical health-related social determinant factors (SDOH) associated with mortality. This study describes novel predictive modeling that uses demographic, clinical, SDOH features from health records data Appalachian community centers to predict 5-year survival. We trained, validated, tested four...
Survivin, a member of inhibitor apoptosis family proteins, plays important roles in both cell proliferation and death. We previously observed that Survivin is overexpressed leukemic lines blasts from patients with acute myelogenous leukemia (AML). To understand the AML search for new approaches to treatment AML, we inhibited expression HL-60 cells anti-sense oligonucleotide (sur-AS-ODN) (ISIS 23722). This blocked significant numbers G2/M phase, halted at 24 hrs progressing over time. There...
Abstract Background Pazopanib is an oral tyrosine-kinase inhibitor that approved by the U.S. Food and Drug Administration for treatment of metastatic renal cell carcinoma (mRCC). Pharmacokinetic data have shown concomitant administration pazopanib esomeprazole, a proton pump (PPI), leads to decreased area under curve thus exposure 40%. Despite pharmacokinetic published date, clinical significance impact on patient outcomes resulting from remains unknown. Materials Methods In this...
Abstract Background: Patients (pts) with non-small-cell lung cancer (NSCLC) who do not achieve pathologic complete response (pCR) after neoadjuvant chemoimmunotherapy and surgery have a worse prognosis than those pCR, escalation of therapy for improved outcomes may be warranted. Pembrolizumab (pembro) is approved in several countries as monotherapy the adjuvant treatment pts NSCLC following pembro plus platinum-based chemotherapy (chemo) resection. V940 (mRNA-4157) novel, mRNA-based,...
Data on COVID-19 outcomes in Asian Americans and Pacific Islanders (AAPI) are lacking. We analyzed data from 6,244 patients the Cancer Consortium, including 6.0% AAPI patients, to examine disparities following acute COVID-19. Despite having lower median BMI than non-Hispanic White (NHW) higher diabetes rates, both groups showed similar 30-day mortality outcomes. In multivariable analyses, morbid obesity (BMI >35 kg/m 2 ) was associated with significantly (OR 4.96; 95% CI 1.78 – 13.88)...
4504 Background: Platinum-based chemotherapy for 1st-line treatment of pts with metastatic urothelial cancer (mUC) is typically administered a fixed duration followed by observation until recurrence. PD-1 blockade pembro improves survival mUC progressing despite platinum-based chemotherapy. We explored the potential benefit earlier use using "switch maintenance" approach. Methods: Pts achieving at least stable disease after up to 8 cycles were enrolled. randomized 1:1 200 mg IV q3 weeks...
During ozone (O 3 ) exposure, adult mice decrease their minute ventilation (V˙e). To determine whether there are age-related differences in the ventilatory response to O , A/J mice, aged 2, 4, 8, or 12 wk, were exposed (0.3–3.0 parts/million for h) nose-only exposure plethysmographs. Baseline V˙e normalized body weight (V˙e/g) decreased with increasing age, consistent higher metabolic rates of younger animals. caused a concentration-related inV˙e all ages, but was significantly less 2-wk-old...