A5011067188- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- Genital Health and Disease
- Global Cancer Incidence and Screening
- Urologic and reproductive health conditions
- Prostate Cancer Treatment and Research
- Multiple and Secondary Primary Cancers
- Esophageal Cancer Research and Treatment
- Pelvic floor disorders treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Policy and Management
- Patient-Provider Communication in Healthcare
- Renal and Vascular Pathologies
- Urinary Tract Infections Management
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Infectious Disease Case Reports and Treatments
- Economic and Financial Impacts of Cancer
- Clinical practice guidelines implementation
Brigham and Women's Hospital
2017-2025
Harvard University
2017-2025
Dana-Farber Cancer Institute
2017-2025
Dana-Farber Brigham Cancer Center
2017-2025
Mass General Brigham
2025
University of Washington
2013-2024
Lemuel Shattuck Hospital
2021
Massachusetts General Hospital
2018
Seattle University
2013-2018
Beijing Administration Institute
2018
Personalized cancer vaccines (PCVs) can generate circulating immune responses against predicted neoantigens1–6. However, whether such target driver mutations, lead to recognition of a patient's tumour and result in clinical activity are largely unknown. These questions particular interest for patients who have tumours with low mutational burden. Here we conducted phase I trial (ClinicalTrials.gov identifier NCT02950766) test neoantigen-targeting PCV high-risk, fully resected clear cell renal...
439 Background: Cisplatin-based neoadjuvant chemotherapy (NAC) in MIBC improves survival which correlates with pathologic response (PaR) at radical cystectomy (RC). The combination of immunotherapy and NAC may improve PaR outcomes MIBC. We tested the efficacy safety nivolumab (N) gemcitabine-cisplatin (GC) as therapy for our phase II trial (NCT03294304). Methods: Eligible pts (cT2-T4a, N≤1, M0) who were candidates RC enrolled. Pts received C (70mg/m2) IV on D1, G (1000mg/m2) D1,D8 N (360 mg)...
Abstract Background Measurement of the parathyroid hormone (PTH) level following total thyroidectomy (TTx) may allow prediction postoperative hypocalcemia. We present an algorithmic method managing hypocalcemia pre‐emptively, based on PTH 1 h after operation. Materials and methods examined 423 consecutive patients undergoing TTx at a single institution. A subset were managed using algorithm involving routine oral calcium administration early addition calcitriol in with low 1‐h level....
Background The use of adjuvant chemotherapy (AC) in pure urothelial carcinoma the bladder is established. Regarding variant histology, there a gap knowledge concerning optimal treatment after radical cystectomy (RC). objective this study was to assess effect AC on overall survival (OS) patients who had carcinoma, with concomitant or another histology. Methods Within National Cancer Data Base, 15,397 underwent RC for nonmetastatic, localized and positive lymph nodes (T2N+) locally advanced...
Although perioperative antibiotic prophylaxis prevents postoperative infectious complications, national guidelines recommend cessation of antibiotics within 24 hours after the procedure. Extended beyond may contribute to hospital acquired infections such as Clostridium difficile colitis. We evaluated practice patterns in genitourinary cancer surgery and assessed impact on C. infections.We identified 59,184 patients treated with radical prostatectomy, 27,921 who underwent partial or...
We investigated the association between race and FT among previous patients with cancer. Studies show that cancer experience financial toxicity (FT) because of their treatment.Data on individuals a history were collected in this cross-sectional study during 2012, 2014, 2017, from US Health Information National Trends Survey. This survey is conducted by mail monetary compensation as an incentive. specifically assessed responses to two questions: Has hurt you financially? Have been denied...
Younger patients with bladder cancer typically have fewer environmental exposures or risk factors, suggesting molecular pathways implicated in early-onset disease differ from older patients. Dissecting the genomic profile of tumors may define targeted treatments for these young We compared frequency somatic mutations cancer, defined as diagnosis before age 55 years old which encompasses about 1 10 diagnoses, two cohorts: Mass General Brigham Young Cystectomy Cohort (MGB-YCC, n=134 patients)...
806 Background: Approximately 75% of patients with non-muscle invasive bladder cancer (NMIBC) treated transurethral resection (TUR) followed by intravesical Bacillus Calmette-Guérin (BCG) experience recurrence. When BCG-unresponsive, most continue to have recurrences even newly approved therapies and nearly 30% progress stages. We developed a first-in-class cancer-specific nanotherapeutic, PPM, which is administered intravesically. Our preclinical data has demonstrated PPM can selectively...
We examined index urological surgeries to assess utilization patterns of antimicrobial prophylaxis in a large, community based population.From the Premier Perspectives Database we identified patients who underwent inpatient that are considered procedures by ABU (American Board Urology), including radical prostatectomy, partial or nephrectomy, cystectomy, ureteroscopy, shock wave lithotripsy, transurethral resection prostate, percutaneous nephrostolithotomy, transvaginal surgery, inflatable...
Infectious, wound and soft tissue events contribute to the morbidity of radical cystectomy but association between these antibiotic prophylaxis is not clear. We sought describe contemporary use in adherence published guidelines, identify regimens with lowest rates infectious events.We identified intraoperative regimen a population based, retrospective cohort study patients who underwent across United States 2003 2013. Multivariable regression was done evaluate 90-day length stay.In weighted...
Background Certain patients with intermediate‐risk prostate cancer (PCa) may be appropriate candidates for active surveillance (AS). In the current study, authors sought to characterize AS use and early mortality outcomes PCa in United States. Methods The novel Surveillance, Epidemiology, End Results Active Surveillance/Watchful Waiting database identified 52,940 men diagnosed National Comprehensive Cancer Network (cT2b‐c, Gleason score of 7, or a prostate‐specific antigen level 10‐20 ng/mL)...
Patients have unprecedented access to their medical records. However, many documents, such as pathology reports, may be beyond the health literacy of most patients. We compared effectiveness bladder biopsy patient centered reports with standard reports.Local cancer experts reached consensus on important elements a report inform prognosis and counseling. Patient focus groups identified formats language convey these constructed pilot report. A total 40 patients undergoing were block randomized...
To quantify the financial impact of complications after radical cystectomy (RC) and their associations with respective 90-day costs, as RC is a morbid surgery plagued by expenditure attributed to specific not well characterised.We used Premier Hospital Database (Premier Inc., Charlotte, NC, USA) identify 9 137 patients (weighted population 57 553) from 360 hospitals between 2003 2013. Complications were categorised according Agency for Healthcare Research Quality Clinical Classifications....