BACKGROUND The clinical courses of patients with medullary thyroid carcinoma (MTC) vary, and a number prognostic factors have been studied, but the significance some these remains controversial. METHODS study group consisted 104 MTC or C-cell hyperplasia managed at hospitals University California, San Francisco, between January 1960 December 1998. Patients were classified as having sporadic MTC, familial non-multiple endocrine neoplasia (MEN) MEN 2A, 2B. TNM, European Organization for...

The epidemiology of primary hyperparathyroidism (PHPT) has generally been studied in Caucasian populations. aim was to examine the incidence and prevalence PHPT within a racially mixed population. A descriptive epidemiologic study performed. population included 3.5 million enrollees Kaiser Permanente Southern California. All patients with at least one elevated serum calcium level (>10.5 mg/dL, 2.6 mmol/L) between 1995 2010 were included. Cases identified by electronic query laboratory values...

Abstract BACKGROUND The prognosis of anaplastic thyroid carcinoma (ATC) has been dismal. objective this study was to identify prognostic factors in patients who had prolonged survival. METHODS Patients with ATC were identified from a computer database at tertiary referral center. Univariate and multivariate analyses for survival differences performed using the Kaplan–Meier log-rank statistic Cox proportional hazards model, respectively. RESULTS Of 33 evaluable patients, median 3.8 months....

Abstract BACKGROUND Follicular thyroid carcinoma (FTC) is the second most common malignancy after papillary carcinoma. The authors studied clinical course of 132 patients with FTC to determine whether there was a direct relation between histologic degree invasion, tumor recurrence, and patient survival. METHODS in study population underwent 182 carcinoma–related operations, their mean follow‐up 7.5 years (median:,6 years; range, 0–39 years). following criteria were used define malignant...

Clinicians have become reliant on fine-needle aspiration (FNA) cytology in the diagnosis of thyroid nodules. We encountered several patients who had cancer at operation despite having FNAs that never showed malignant or suspicious cells. Hence, we retrospectively studied 100 consecutive with histologically proven undergone preoperative FNA. Fourteen these cancers were not detected by FNA, three whom developed widespread disease. The sensitivity FNA was 79%, false-negative rate 21%, and...

To determine whether preoperative and postoperative symptoms outcome differ in patients who meet or fail to the NIH criteria for parathyroidectomy.The Consensus Conference on primary hyperparathyroidism 1990 defined surgical intervention suggesting that some can be safely managed without surgery.Over a 3-year period, 202 consecutive undergoing parathyroidectomy at tertiary referral center were prospectively given questionnaire regarding their associated conditions during initial follow-up...

The comparative effectiveness of surgical and medical treatments on fracture risk in primary hyperparathyroidism (PHPT) is unknown.To measure the relationship parathyroidectomy bisphosphonates with skeletal outcomes patients PHPT.Retrospective cohort study.An integrated health care delivery system.All enrollees biochemically confirmed PHPT from 1995 to 2010.Bone mineral density (BMD) changes rate.In 2013 serial bone examinations, total hip BMD increased transiently women (4.2% at <2 years)...

This study aims to evaluate our institution's experience with thyroidectomy for Graves' disease, an emphasis on indications and long-term outcomes. The cohort consisted of 103 patients (mean age 34.3 [±13.9] years), who underwent disease between 1991 2002. Clinical follow-up data were obtained by retrospective review medical records contacting treating physicians or patients. most common surgical patient preference (26%), cold nodule (24%), eye symptoms (20%), large goiter size (18%),...

Abstract Background Measurement of the parathyroid hormone (PTH) level following total thyroidectomy (TTx) may allow prediction postoperative hypocalcemia. We present an algorithmic method managing hypocalcemia pre‐emptively, based on PTH 1 h after operation. Materials and methods examined 423 consecutive patients undergoing TTx at a single institution. A subset were managed using algorithm involving routine oral calcium administration early addition calcitriol in with low 1‐h level....

Minimally invasive parathyroidectomy (MIP) is the preferred approach to primary hyperparathyroidism (PHPT) when a single adenoma can be localized preoperatively. The added value of intraoperative parathyroid hormone (IOPTH) monitoring remains debated because its ability prevent failed due unrecognized multiple gland disease (MGD) must balanced against assay-related costs. We used decision tree and cost analysis model examine IOPTH in PHPT. Literature review identified 17 studies involving...

In Brief Objective: To examine trends in the frequency and quality of surgery for primary hyperparathyroidism (PHPT) California during period 1999 to 2008. Background: The PHPT can be measured by complication rate success surgery. A fraction patients with failed initial undergo reoperation. Methods: Data on undergoing parathyroidectomy (PTx) were obtained from Office Statewide Health Planning Development. Renal transplant recipients dialysis excluded. Hospitals categorized case volume: Very...

The aim of this study was to determine outcomes primary tumor resection in metastatic neuroendocrine tumors across all sites.Primary (PTR) may offer a survival benefit gastrointestinal (GI-NETs); however, few studies have examined the effect site and grade on survival.This is retrospective patients with GI-NETs at presentation between 2005 2011 using California Cancer Registry (CCR) dataset merged Office Statewide Health Planning Development (OSHPD) inpatient longitudinal database. Primary...

In patients with intrahepatic cholangiocarcinoma (ICC), the oncologic benefit of surgery and perioperative outcomes for large multifocal tumors or contiguous organ involvement remain to be defined.To develop externally validate a simplified prognostic score ICC determine ICCs involvement.This study contemporary cohort merged data from California Cancer Registry (January 1, 2004, through December 31, 2011) Office Statewide Health Planning Development inpatient database. Clinicopathologic...

Abstract Background Selected studies have reported improved outcomes in laparoscopic compared with open distal pancreatic resection. Concerns regarding failure to achieve proper oncological resection and compromised long-term remain. This study investigated whether postoperative survival after pancreatectomy are comparable those an procedure. Methods retrospective case–control included patients who underwent for resectable adenocarcinoma between 2010 2013, identified from the National Cancer...

Abstract Social control, social support, and companionship represent basic elements of many close relationships, yet we know relatively little about how these distinctive separately jointly influence relationship quality. Control support may have incompatible effects, with efforts by a family member or friend to focal person's behavior undermining the sense in relationship. We examined implications for perceived quality older adults’family relationships friendships sample 180 adults....