A5045516749- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Parathyroid Disorders and Treatments
- Thyroid Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Diversity and Career in Medicine
- Pituitary Gland Disorders and Treatments
- Medical Education and Admissions
- Genetic Syndromes and Imprinting
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Innovations in Medical Education
- Intestinal Malrotation and Obstruction Disorders
- Histone Deacetylase Inhibitors Research
- Intestinal and Peritoneal Adhesions
- Cancer, Stress, Anesthesia, and Immune Response
- Hernia repair and management
- Radiation Dose and Imaging
- Immunotherapy and Immune Responses
- Medical Imaging and Pathology Studies
- Head and Neck Anomalies
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Hormonal Regulation and Hypertension
- Radiomics and Machine Learning in Medical Imaging
Johns Hopkins Medicine
2021-2025
Johns Hopkins University
2021-2025
University of Baltimore
2022
Johns Hopkins Hospital
2022
Cedars-Sinai Medical Center
2000-2021
University of Arizona
2019-2021
Mayo Clinic in Arizona
2020
The University of Texas Rio Grande Valley
2020
University of Cape Town
2020
The University of Texas MD Anderson Cancer Center
2011-2016
Age is a critical factor in outcome for patients with well-differentiated thyroid cancer. Currently, age 45 years used as cutoff staging, although there increasing evidence to suggest this may be too low. The aim of study was assess the potential changing cut point American Joint Committee on Cancer/Union International Cancer Control (AJCC/UICC) staging system from 55 based combined international patient cohort supplied by individual institutions.
Adrenalectomy is the definitive treatment for multiple adrenal abnormalities. Advances in technology and genomics an improved understanding of pathophysiology have altered operative techniques indications.To develop evidence-based recommendations to enhance appropriate, safe, effective approaches adrenalectomy.A multidisciplinary panel identified investigated 7 categories relevant clinical concern practicing surgeons. Questions were structured framework Population, Intervention/Exposure,...
Tumors grow in the presence of antigen-specific T cells, suggesting existence intrinsic cancer cell escape mechanisms. We hypothesized that a histone deacetylase (HDAC) inhibitor could sensitize tumor cells to immunotherapy because this class agents has been reported increase antigen expression and shift gene proapoptotic milieu cells. To test question, we treated B16 murine melanoma with combination HDAC LAQ824 adoptive transfer gp100 pmel-1 The combined therapy significantly improved...
Abstract Purpose: CTL-associated antigen 4 (CTLA4)-blocking monoclonal antibodies induce long-term regression of metastatic melanoma in some patients, but the exact mechanism is unknown. In this study, biopsies selected accessible tumor lesions from patients treated with tremelimumab were examined to further elucidate its antitumor activity. Experimental Design: Fifteen 7 who had been (CP-675,206) collected. Samples analyzed for markers, immune cell subset presence T regulatory-specific...
Minimally invasive parathyroidectomy (MIP) is the preferred approach to primary hyperparathyroidism (PHPT) when a single adenoma can be localized preoperatively. The added value of intraoperative parathyroid hormone (IOPTH) monitoring remains debated because its ability prevent failed due unrecognized multiple gland disease (MGD) must balanced against assay-related costs. We used decision tree and cost analysis model examine IOPTH in PHPT. Literature review identified 17 studies involving...
Importance Intraoperative nerve monitoring (IONM) is not considered standard of care during thyroidectomy, and guidelines are vague about its use in the absence strong evidence superiority over visualization recurrent laryngeal (RLN) alone. Objective To characterize patterns IONM thyroidectomy US evaluate association with postoperative outcomes. Design, Setting, Participants This cohort study used National Surgical Quality Improvement Program (NSQIP) data from January 1, 2016, to December...
Thyroid stunning has been reported as the temporary impairment of thyroid tissue after a 111-MBq or greater diagnostic 131I dose that decreases final absorbed in ablative therapy. Concerns regarding reality have arisen part due to flawed study design prior reports. To assess whether effect any impact on therapeutic outcomes, we compared initial treatment ablation rates patients who received 111- 185-MBq scans (n = 37) before doses 3700–7400 MBq with did not receive 63). Ablation were 64.9%...
Prior analyses of the impact stringent, preablative low-iodine diets (LIDs) on ablation in patients with differentiated thyroid cancer postthyroidectomy are dated. We retrospectively reviewed first-time, short-term rates for 44 LID and 50 following a regular diet (RD) who were verbally instructed to avoid salt, seafood, multivitamins containing iodine. Patients had undergone given between 100 200 mCi 131I, depending presence metastases. found 68.2% rate patients, compared 62.0% RD...
Abstract Background Limited data exists suggesting that cumulative exposure to air pollution in the form of fine particulate matter (aerodynamic diameter ≤ 2.5 μm [PM ]) may be associated with papillary thyroid carcinoma (PTC), although this relationship has not been widely established. This study aims evaluate association between PM and PTC determine subgroups patients who are at highest risk diagnosis. Methods Under IRB approval, we conducted a case-control adult (age ≥ 18) newly diagnosed...
Abstract Introduction. The prevalence of primary hyperparathyroidism (PHPT) is expected to increase in developed nations as the aged population grows. This review discusses issues related PHPT elderly with a focus on differences disease presentation, medical and surgical management, outcomes. Methods. Literature English-language studies or parathyroidectomy (PTx) was performed. Surgical literature reviewed included original clinical published after 1990. Priority given >30 patients...
Tumor antigen-reactive T cells must enter into an immunosuppressive tumor microenvironment, continue to produce cytokine and deliver apoptotic death signals affect regression. Many tumors transforming growth factor beta (TGFβ), which inhibits cell activation, proliferation cytotoxicity. In a murine model of adoptive therapy, we demonstrate that transgenic Pmel-1 CD8 cells, rendered insensitive TGFβ by transduction with dominant negative receptor II (DN), were more effective in mediating...