A5055888408- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- COVID-19 and healthcare impacts
- Tracheal and airway disorders
- Thyroid Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer survivorship and care
- Salivary Gland Tumors Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Global Cancer Incidence and Screening
- Thyroid and Parathyroid Surgery
- Ear and Head Tumors
- Lung Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Palliative Care and End-of-Life Issues
- Oral health in cancer treatment
- Brain Metastases and Treatment
- Head and Neck Anomalies
- Hearing Loss and Rehabilitation
- Patient-Provider Communication in Healthcare
- Airway Management and Intubation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diversity and Career in Medicine
University of Toronto
2016-2025
Sunnybrook Health Science Centre
2017-2025
Health Sciences Centre
2017-2025
Sunnybrook Hospital
2023-2025
Institute for Clinical Evaluative Sciences
2018-2025
Sunnybrook Research Institute
2019-2025
Public Health Ontario
2020-2024
Toronto East General Hospital
2018-2024
University of Cagliari
2023
St. Louis County Missouri
2022-2023
Age is a critical factor in outcome for patients with well-differentiated thyroid cancer. Currently, age 45 years used as cutoff staging, although there increasing evidence to suggest this may be too low. The aim of study was assess the potential changing cut point American Joint Committee on Cancer/Union International Cancer Control (AJCC/UICC) staging system from 55 based combined international patient cohort supplied by individual institutions.
The optimal approach for treatment deescalation in human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCCs) is unknown.To assess a primary radiotherapy (RT) vs transoral surgical (TOS) HPV-related OPSCC.This international, multicenter, open-label parallel-group phase 2 randomized clinical trial was conducted at 9 tertiary academic cancer centers Canada and Australia enrolled patients with T1-T2N0-2 p16-positive OPSCC between February 13, 2018, November 17, 2020....
Background: In most staging systems, 45 years of age is used to differentiate low risk thyroid cancer from high cancer. However, recent studies have questioned both the precise year point and concept using a binary cut off as accurate predictors disease specific mortality. Methods: A cohort 3664 patients that received surgery adjuvant treatment at Memorial Sloan Kettering Cancer Center (MSKCC) 1985 2010 were analyzed determine significance diagnosis categorical variable variety cutoffs (5...
Objective To (1) determine the overall complication rate, wound healing, and infection complications (2) identify preoperative, intraoperative, postoperative predictors of these complications. Study Design Case series with chart review. Setting Tertiary academic cancer hospital. Subjects Methods All head neck free flap patients at The Ohio State University (2006-2012) were assessed. Multivariable logistic regression assessed impact patient factors, intraoperative factors on aforementioned...
Intraoperative anesthesiology care is crucial to high-quality surgical care. The clinical expertise and experience of anesthesiologists may decrease the risk adverse outcomes.To examine association between anesthesiologist volume short-term postoperative outcomes for complex gastrointestinal (GI) cancer surgery.This population-based cohort study used administrative health data sets from various sources in Ontario, Canada. Adult patients who underwent esophagectomy, pancreatectomy, or...
Resource restrictions were established in many jurisdictions to maintain health system capacity during the COVID-19 pandemic. Disrupted healthcare access likely impacted early cancer detection. The objective of this study was assess impact pandemic on weekly reported incidence.This a population-based involving individuals diagnosed with from September 25, 2016, 26, 2020, Ontario, Canada. Weekly incidence counts examined using segmented negative binomial regression models. estimated backlog...
The surgeon-anesthesiologist teamwork and relationship is crucial to good patient outcomes. Familiarity among work team members associated with enhanced success in multiple fields but rarely studied the operating room.
Abstract Background Team diversity is recognized not only as an equity issue but also a catalyst for improved performance through in knowledge and practices. However, team data healthcare are limited it known whether may affect outcomes surgery. This study examined the association between anaesthesia–surgery sex postoperative outcomes. Methods was population-based retrospective cohort of adults undergoing major inpatient procedures 2009 2019. The exposure hospital percentage female...
The importance of reporting and grading surgical complications is central to quality improvement in head neck surgery. purpose this study assess the interobserver reliability, content validity, construct validity Clavien-Dindo classification system for use related surgery.1 2.Hypothetical cases common complications, along with a brief questionnaire, were responded by 81 residents, fellows, surgeons reliability system. Construct was assessed priori hypothesis that increasing complication...
We aimed to assess whether surgeon and/or institution resection volume predicts long-term overall survival in head and neck cancer a publicly funded healthcare system.Population-based retrospective cohort study.Head patients Ontario, Canada, who underwent confirmed by both hospital-level physician-level administrative data between 1993 2010, comprised our (N = 5,720). Physician hospital volumes were calculated based on number of cases performed the year prior physician at an performing each...
Abstract Background Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) than patients HPV-negative disease. Treatment options for HPV+ OPC can involve either a primary radiotherapy (RT) approach (± concomitant chemotherapy) or surgical adjuvant radiation) transoral surgery (TOS). These two paradigms different spectrums of toxicity. The goals this study are to assess the OS...
Background: Active surveillance (AS) of small, low-risk papillary thyroid cancers (PTCs) is increasingly being considered. There limited understanding why individuals with PTC may choose AS over traditional surgical management. Methods: We present a mixed-methods analysis prospective observational real-life decision-making study regarding the choice thyroidectomy or for management localized, PTCs <2 cm in maximum diameter (NCT03271892). Patients were provided standardized medical information...
Background: It is important to understand patient preferences on managing low-risk papillary thyroid cancer (PTC). Methods: We prospectively followed patients with PTC <2 cm in maximal diameter, who were offered the choice of thyroidectomy or active surveillance (AS) at University Health Network (UHN), Toronto, Canada. The primary outcome was frequency AS (percentage confidence interval [CI]). Univariate and multivariable analyses performed identify predictors AS. Results: enrolled 200...
There is epidemiologic evidence that the increasing incidence of thyroid cancer associated with subclinical disease detection. Evidence for a true increase in has also been identified. However, would likely be heralded by an increased thyroid-referable symptoms patients presenting disease.To evaluate whether modes detection (MODs) used to identify nodules surgical removal have changed compared historic data and determine if MODs vary geographic location.This was retrospective analysis...
Oral cavity cancer often requires multidisciplinary management, subjecting patients to complex therapeutic trajectories. Prolonged treatment intervals in oral have been associated with poor oncological outcomes, but there has yet be a study investigating times Canada.
Melanoma treatment has evolved during the past decade with adoption of adjuvant and palliative immunotherapy targeted therapies, an unclear impact on health care costs outcomes in routine practice.