A5046689971- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Valve Diseases and Treatments
- Advanced Radiotherapy Techniques
- Head and Neck Surgical Oncology
- Sarcoma Diagnosis and Treatment
- Soft Robotics and Applications
- Cancer-related molecular mechanisms research
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Advanced X-ray and CT Imaging
- Oral health in cancer treatment
- Infective Endocarditis Diagnosis and Management
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Colorectal and Anal Carcinomas
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Management of metastatic bone disease
- Aortic aneurysm repair treatments
- Cardiac tumors and thrombi
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Salivary Gland Tumors Diagnosis and Treatment
Western University
2010-2025
London Health Sciences Centre
2010-2025
Edinburgh Royal Infirmary
2023
Cancer Care Ontario
2021-2022
Western University of Health Sciences
2020
Sunnybrook Health Science Centre
2017-2019
Health Sciences Centre
2017-2019
University of Toronto
2016
Robarts Clinical Trials
2010-2012
DKFZ-ZMBH Alliance
2008
IntroductionThe use of stereotactic body radiotherapy (SBRT) for tumors in close proximity to the central mediastinal structures has been associated with a high risk toxicity. This study (BLINDED FOR REVIEW) aimed determine maximally tolerated dose (MTD) SBRT ultra-central (UC) non-small cell lung carcinoma (NSCLC), using time-to-event continual reassessment methodology (TITE-CRM).MethodsPatients T1-3N0M0 (≤ 6 cm) NSCLC were eligible. The MTD was defined as ≤ 30% rate grade (G) 3-5...
Abstract Background Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) than patients HPV-negative disease. Treatment options for HPV+ OPC can involve either a primary radiotherapy (RT) approach (± concomitant chemotherapy) or surgical adjuvant radiation) transoral surgery (TOS). These two paradigms different spectrums of toxicity. The goals this study are to assess the OS...
BackgroundThere is significant interest in treatment de-escalation for human papillomavirus-associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients given the generally favourable prognosis. However, 15–30% of recur after primary treatment, reflecting a need improved risk-stratification tools. We sought to develop molecular test risk stratify HPV+ OPSCC patients.MethodsWe created an immune score (UWO3) associated with survival outcomes six independent cohorts comprising 906...
The treatment of patients with HPV-associated oropharyngeal cancer (HPV-OPC) is rapidly evolving and challenging the standard care definitive radiotherapy concurrent cisplatin. There are numerous promising de-escalation strategies under investigation, including deintensified chemoradiotherapy, transoral surgery followed by de-escalated adjuvant therapy, induction chemotherapy locoregional therapy. Definitive alone or cetuximab not recommended for curative-intent locally advanced HPV-OPC....
Transcatheter aortic valve implantation is a minimally invasive alternative to open-heart surgery for stenosis in which stent-based bioprosthetic delivered into the heart on catheter. Limited visualization during this procedure can lead severe complications. Improved be provided by live registration of transesophageal echo (TEE) and fluoroscopy images intraoperatively. Since TEE probe always visible image, it possible track using fiducial-based single-perspective pose estimation. In study,...
Objective Emerging off-pump beating heart valve repair techniques offer patients less invasive alternatives for mitral (MV) repair. However, most of these rely on the limited spatial and temporal resolution transesophageal echocardiography (TEE) alone, which can make tool visualization guidance challenging. Methods Using a magnetic tracking system integrated sensors, we created an augmented reality (AR) environment displaying virtual representations important intracardiac landmarks...
Laryngeal squamous cell carcinoma (LSCC) from different subsites have distinct presentations and prognosis. In this study, we carried out a multiomic comparison of LSCC subsites. The Cancer Genome Atlas (TCGA) cohort was analyzed in the R statistical environment for differences between supraglottic glottic cancers single nucleotide variations (SNVs), copy number alterations (CNAs), mRNA abundance, protein pathway overrepresentation, tumor microenvironment (TME), hypoxia status, patient...
Transcatheter aortic valve implantation (TAVI) is a minimally invasive alternative to conventional replacement for severe stenosis in high-risk patients which stent-based bioprosthetic delivered into the heart via catheter. TAVI relies largely on single-plane fluoroscopy intraoperative navigation and guidance, provides only gross imaging of anatomical structures. Inadequate leading suboptimal positioning contributes many early complications experienced by patients, including embolism,...
Abstract Background Transoral surgery (TOS), particularly transoral robotic (TORS) has become the preferred modality in United States for treatment of early stage oropharyngeal cancer, largely due to assumptions fewer toxicities and improved quality life compared primary radiotherapy (RT). However, these are based on retrospective analysis, a subset which utilize RT groups not limited T1-2 tumors is FDA approved. Thus, there potential underestimating survival overestimating toxicity,...
Abstract Background Numerous studies of head and neck squamous cell carcinoma (HNSCC) have demonstrated disparate outcomes by race ethnicity. Beyond known associations with socioeconomic variables, whether these are also associated differences in tumor molecular composition has thus far been poorly explored. Methods We downloaded clinical multiplatform data from The Cancer Genome Atlas other published studies. These were compared between non‐Hispanic Black ( n = 43) White 354) patients...
6006 Background: NRG-HN002 was a phase II trial that randomized patients with p16-positive oropharynx cancer to 60 Gy IMRT concurrent cisplatin (IMRT-C) or accelerated IMRT. The protocol specified plasma collection at pretreatment (t0), intratreatment (20-28 Gy, t1), and 2 weeks 1 month posttreatment (t2); these timepoints, TTMV assayed. A prespecified analysis evaluated: association of t0 gross tumor volume (GTV) primary lymph nodes; t0-t1 decrease in TTMV; t2 treatment outcome. Methods:...
Stability of a cemented implant, once the stem-cement interface has debonded, is reliant upon stem geometry and surface finish. There are relatively few studies addressing effect cross-sectional shape on implant fixation. The purpose this investigation was to compare torsional stability five different shapes—circular, oval, triangular, rectangular with rounded edges, sharp edges—under monotonically increasing cyclic loading conditions. Seven samples each were tested. Stems potted in bone...