A5002196476- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- 3D Printing in Biomedical Research
- Medical Imaging Techniques and Applications
- Airway Management and Intubation Techniques
- ATP Synthase and ATPases Research
- Colorectal Cancer Surgical Treatments
- Anesthesia and Sedative Agents
- Minimally Invasive Surgical Techniques
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neural Engineering
- Nanoplatforms for cancer theranostics
- Respiratory Support and Mechanisms
- Anesthesia and Pain Management
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Diverticular Disease and Complications
- Management of metastatic bone disease
- Cardiac Arrest and Resuscitation
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Brain Metastases and Treatment
- MRI in cancer diagnosis
- Tracheal and airway disorders
The University of Texas MD Anderson Cancer Center
2022-2025
The University of Texas Health Science Center at Houston
2008-2025
Loyola University Medical Center
2016-2025
Sankalchand Patel University
2024
University Health Network
2009-2023
Stanford University
2016-2023
Stanford Medicine
2022
Health Sciences Centre
2017-2022
Sunnybrook Health Science Centre
2017-2022
University College London Hospitals NHS Foundation Trust
2021-2022
Robotic-assisted laparoscopic surgery (RALS) is evolving as an important surgical approach in the field of colorectal surgery. We aimed to evaluate learning curve for RALS procedures involving resections rectum and rectosigmoid.A series 50 consecutive were performed between August 2008 September 2009. Data entered into a retrospective database later abstracted analysis. The included abdominoperineal resection (APR), anterior rectosigmoidectomy (AR), low (LAR), rectopexy (RP). Demographic...
<h2>Summary</h2><h3>Background</h3> High blood pressure is common in acute stroke and a predictor of poor outcome; however, large trials lowering have given variable results, the management high ultra-acute remains unclear. We investigated whether transdermal glyceryl trinitrate (GTN; also known as nitroglycerin), nitric oxide donor, might improve outcome when administered very early after onset. <h3>Methods</h3> did multicentre, paramedic-delivered, ambulance-based, prospective, randomised,...
Magnetic resonance imaging (MRI) with targeted biopsy is an appealing alternative to systematic 12-core transrectal ultrasonography (TRUS) for prostate cancer diagnosis, but has yet be widely adopted.To determine whether MRI only was noninferior TRUS biopsies in the detection of International Society Urological Pathology grade group (GG) 2 or greater cancer.This multicenter, prospective randomized clinical trial conducted 5 Canadian academic health sciences centers between January 2017 and...
Abstract Glioblastoma is the most common yet lethal of primary brain cancers with a one-year post-diagnosis survival rate 65% and five-year barely 5%. Recently U.S. Food Drug Administration approved novel fourth approach (in addition to surgery, radiation therapy, chemotherapy) treating glioblastoma; namely, tumor fields (TTFields). TTFields involves delivery alternating electric but its mechanisms action are not fully understood. Current theories involve disrupting mitosis due interference...
Summary Clinical observations suggest that compared with standard apnoeic oxygenation, transnasal humidified rapid‐insufflation ventilatory exchange using high‐flow nasal oxygenation reduces the rate of carbon dioxide accumulation in patients who are anaesthetised and apnoeic. This suggests active gas takes place, but mechanisms by which it may occur have not been described. We used three laboratory airway models to investigate clearance patients. determined flow patterns particle image...
Recent advances in novel immune strategies, particularly chimeric antigen receptor (CAR)-bearing T-cells, have shown limited efficacy against glioblastoma (GBM) clinical trials. We currently an incomplete understanding of how these emerging therapies integrate with the current standard care, specifically radiation therapy (RT). Additionally, there is insufficient number preclinical studies monitoring high spatiotemporal resolution. To address limitations, we report first longitudinal...
Nanoparticles' enhanced permeation and retention (EPR) variations due to tumor heterogeneity in naturally occurring brain tumors are commonly neglected preclinical nanomedicine studies. Recent pathological studies have shown striking similarities between humans dogs, indicating that canine may be a valuable model evaluate nanoparticles' EPR this context. We recruited clinical cases with spontaneous investigate different pathologies using surface-enhanced Raman spectroscopy (SERS). used gold...
Abstract Cerebrospinal fluid (CSF) analysis is underutilized in patients with glioblastoma (GBM), partly due to a lack of studies demonstrating the clinical utility CSF biomarkers. While some show cell-free DNA analysis, analyzing metabolites are limited. Diffuse gliomas have altered cellular metabolism. For example, mutations isocitrate dehydrogenase enzymes (e.g., IDH1 and IDH2 ) common diffuse lead increased levels D-2-hydroxyglutarate CSF. However, there poor understanding changes GBM...
Abstract After a primary traumatic injury, spinal cord tissue undergoes series of pathobiological changes, including compromised blood–spinal barrier (BSCB) integrity. These vascular changes occur over both time and space. In an experimental model injury (SCI), longitudinal dynamic contrast‐enhanced MRI (DCE‐MRI) studies were performed up to 56 days after SCI quantify spatial temporal in the BSCB permeability that did not show any visible enhancement on post‐contrast (non‐enhancing tissue)....
PURPOSE: Robotic-assisted laparoscopic surgery is an emerging modality in the field of minimally invasive colorectal surgery. However, there a dearth data comparing outcomes with other techniques. We present 3-arm (conventional, hand-assisted, and robotic) matched-case analysis intraoperative short-term patients undergoing procedures. METHODS: Between August 2008 October 2009, 70 robotic cases rectum rectosigmoid were performed. Thirty these organized into triplets conventional hand-assisted...
Physician-scientists, with in-depth training in both medicine and research, are uniquely poised to address pressing challenges at the forefront of biomedicine. In recent years, a number organizations have outlined obstacles maintaining pipeline physician-scientists, classifying them as an endangered species. As in-training early-career physician-scientists across spectrum pipeline, we share here our perspective on current available opportunities that might aid generation becoming independent...
The process of documentation in electronic health records (EHRs) is known to be time consuming, inefficient, and cumbersome. use dictation coupled with manual transcription has become an increasingly common practice. In recent years, natural language processing (NLP)-enabled data capture a viable alternative for entry. It enables the clinician maintain control potentially reduce burden. question remains how this NLP-enabled workflow will impact EHR usability whether it can meet structured...
Abstract The immune checkpoint programmed death 1 receptor (PD-1) expressed on some tumor-infiltrating lymphocytes, and its ligand (PD-L1) tumor cells, enable cancers to evade the system. Blocking PD-1 with monoclonal antibody pembrolizumab is a promising immunotherapy strategy. Thus, noninvasively quantifying presence of expression in microenvironment prior initiation blockade may identify patients likely respond therapy. We have developed 64 Cu-pembrolizumab radiotracer evaluated human...
: First-line therapy for high-grade gliomas (HGGs) includes maximal safe surgical resection. The extent of resection predicts overall survival, but current neuroimaging approaches lack tumor specificity. epidermal growth factor receptor (EGFR) is a highly expressed HGG biomarker. We evaluated the safety and feasibility an anti-EGFR antibody, panitumuab-IRDye800, at subtherapeutic doses as imaging agent HGG.
Objectives Our objective was to compare prostate cancer detection rates between patients undergoing serum prostate-specific antigen (PSA) vs magnetic resonance imaging (MRI) for screening. Design Phase III open-label randomised controlled trial. Setting Single tertiary centre in Toronto, Canada. Participants Men 50 years of age and older with no history PSA screening ≥3 years, a negative digital rectal exam prior biopsy. Interventions Patients were recommended undergo biopsy if their ≥2.6...
Numerous studies have associated high concentrations of lipoprotein(a) [Lp(a)] with atherosclerosis. We developed a rapid, one-step competitive immunochromatographic assay to measure Lp(a) in plasma. The is performed on nitrocellulose membrane strip and the result determined by visual readout rust-colored colloidal selenium. based principle that sample will compete Lp(a)-coated selenium for binding anti-Lp(a) monoclonal antibody immobilized format four ladder bars. number capture bars appear...
Restorative proctocolectomy (RP) with ileal pouch-anal anastomosis (IPAA) is the surgical procedure of choice for chronic ulcerative colitis (CUC). Robotic-assisted laparoscopic surgery (RALS) has been shown to have its greatest merits in colorectal procedures involving pelvis. The aim this study was evaluate safety and feasibility RP IPAA using an innovative robotic technique. A total five consecutive patients underwent RALS between August 2008 February 2010. Patient demographics,...