A5026946585- Glioma Diagnosis and Treatment
- Virus-based gene therapy research
- Veterinary Oncology Research
- Medical Imaging and Pathology Studies
- Veterinary Orthopedics and Neurology
- Cancer Research and Treatments
- Hedgehog Signaling Pathway Studies
- Meningioma and schwannoma management
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Brain Metastases and Treatment
- Connective tissue disorders research
- Cancer, Hypoxia, and Metabolism
- Education Systems and Policy
- Infectious Encephalopathies and Encephalitis
- Cerebrospinal fluid and hydrocephalus
- Fibroblast Growth Factor Research
- Neurological diseases and metabolism
- RNA Interference and Gene Delivery
- Bone Tumor Diagnosis and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- RNA Research and Splicing
- Metabolism and Genetic Disorders
- Immunotherapy and Immune Responses
- Head and Neck Surgical Oncology
University of California, Davis
2015-2024
UC Davis Comprehensive Cancer Center
2023
University of Warwick
2019-2021
Liverpool John Moores University
2020
Institute for Employment Studies
2019
Virginia–Maryland College of Veterinary Medicine
2016
Auburn University
2016
National Cancer Institute
2016
Center for Cancer Research
2016
Cornell University
2016
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTubulin-nucleotide interactions during the polymerization and depolymerization of microtubulesRichard C. Weisenberg, William J. Deery, Peter DickinsonCite this: Biochemistry 1976, 15, 19, 4248–4254Publication Date (Print):September 21, 1976Publication History Published online1 May 2002Published inissue 21 September 1976https://doi.org/10.1021/bi00664a018RIGHTS & PERMISSIONSArticle Views600Altmetric-Citations217LEARN ABOUT THESE METRICSArticle Views...
Background: Intracranial meningiomas are the most common primary brain tumors in dogs. Classification of by tumor grade and subtype has not been reported, value magnetic resonance imaging (MRI) characteristics for predicting investigated. Hypothesis: Canine intracranial a heterogenous group with differing histological subtypes grades. Prediction histopathological classification is possible based on MRI characteristics. Animals: One hundred twelve dogs diagnosis meningioma. Methods:...
Significance Chondrodystrophy, characterized by short limbs and intervertebral disc disease (IVDD), is a common phenotype in many of the most popular dog breeds, including dachshund, beagle, French bulldog. Here, we report identification FGF4 retrogene insertion on chromosome 12, second reported dog, as responsible for chondrodystrophy IVDD. Identification causative mutation IVDD will impact an incredibly large proportion population provides model humans, FGF-associated mutations are stature...
Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared molecular profiles of canine with those human pediatric adult to characterize evolutionarily conserved mammalian mutational processes gliomagenesis. Employing whole-genome, exome, transcriptome, methylation sequencing 83 gliomas, we found alterations shared such as receptor tyrosine kinases, TP53 cell-cycle pathways, IDH1 R132. Canine showed high similarity...
Feline infectious peritonitis (FIP) is caused by a mutant biotype of the feline enteric coronavirus. The resulting FIP virus (FIPV) commonly causes central nervous system (CNS) and ocular pathology in cases noneffusive disease. Over 95% cats with will succumb to disease days months after diagnosis despite variety historically used treatments. Recently developed antiviral drugs have shown promise treatment nonneurological FIP, but data from neurological are limited. Four naturally occurring...
Abstract Meningiomas are the most common primary intracranial tumors. Treatments for patients with meningiomas limited to surgery and radiotherapy, systemic therapies remain ineffective or experimental. Resistance radiotherapy is in high-grade cell types signaling mechanisms that drive meningioma tumorigenesis resistance incompletely understood. Here, we report NOTCH3 drives find perivascular NOTCH3+ stem cells conserved across from humans, dogs, mice. Integrating single-cell transcriptomics...
Although glioblastoma multiforme (GBM), a World Health Organization grade IV astrocytoma, is the most common primary brain tumor in humans, dogs GBM relatively rare, accounting for only about 5% of all astrocytomas. This study presents combined clinical, neuroimaging, and neuropathologic findings five with GBM. The dogs, aged from 5 to 12 years, were presented progressive neurologic deficits that subsequent clinical examination neuroimaging studies by magnetic resonance imaging (MRI),...
Background: Choroid plexus tumors (CPTs) comprise approximately 10% of all primary brain in dogs. The clinical utility magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, or both the presumptive diagnosis CPTs has not been determined. Objectives: To report MRI and CSF findings dogs with CPT determine if there are distinguishing features that allow discrimination between tumor grades. Animals: Fifty‐six client‐owned naturally occurring CPT. Methods: Retrospective case...
The domestic dog, Canis familiaris, exhibits profound phenotypic diversity and is an ideal model organism for the genetic dissection of simple complex traits. However, some most interesting phenotypes are fixed in particular breeds therefore less tractable to analysis using classical segregation-based mapping approaches. We implemented across breed approach a moderately dense SNP array, low number animals carefully selected interest identify variants responsible breed-defining...
To compare clinical features of cryptococcosis among cats and dogs in California, determine whether the distribution involved tissues differs from reported previously a study southeastern Australia, identify Cryptococcus spp isolated population.Retrospective case series.62 31 with cryptococcosis.Medical records were reviewed. Information collected included geographic location, species, signalment, or organs involved. Cryptococcosis was confirmed via serology, cytology, histology, microbial...
Canine spontaneous intracranial tumors bear striking similarities to their human tumor counterparts and have the potential provide a large animal model system for more realistic validation of novel therapies typically developed in small rodent models. We used spontaneously occurring canine gliomas investigate use convection-enhanced delivery (CED) liposomal nanoparticles, containing topoisomerase inhibitor CPT-11. To facilitate visualization intratumoral infusions by real-time magnetic...
Cryptococcus spp. is a fungal pathogen with predilection for the central nervous system (CNS).To compare clinical, advanced imaging, and neuropathologic findings in dogs cats CNS cryptococcosis, to evaluate outcome of treatment these animals.Twenty-six 21 cryptococcosis.Medical records were reviewed clinical results imaging. Archived cerebrospinal fluid tissue specimens pathology. Findings compared those effects variables on survival determined by curve analysis.When present, pain was...
Domestic dog breeds exhibit remarkable morphological variations that result from centuries of artificial selection and breeding. Identifying the genetic changes contribute to these could provide critical insights into molecular basis tissue organismal morphogenesis. Bulldogs, French Bulldogs Boston Terriers share many disease-predisposition traits, including brachycephalic skull morphology, widely set eyes short stature. Unlike other dogs, also vertebral malformations in a truncated, kinked...
Nanoparticles' enhanced permeation and retention (EPR) variations due to tumor heterogeneity in naturally occurring brain tumors are commonly neglected preclinical nanomedicine studies. Recent pathological studies have shown striking similarities between humans dogs, indicating that canine may be a valuable model evaluate nanoparticles' EPR this context. We recruited clinical cases with spontaneous investigate different pathologies using surface-enhanced Raman spectroscopy (SERS). used gold...
We investigated the association of multiple single nucleotide polymorphisms (SNPs) with athlete status and power/speed performance in elite male youth soccer players (ESP) control participants (CON) at different stages maturity. ESP (n = 535; aged 8-23 years) CON 151; 9-26 were genotyped for 10 SNPs grouped according to years from predicted peak-height-velocity (PHV), i.e. pre- or post-PHV, determine maturity status. Participants performed bilateral vertical countermovement jumps,...
The authors have shown that convection-enhanced delivery (CED) of gadoteridol-loaded liposomes (GDLs) into different regions normal monkey brain results in predictable, widespread distribution this tracking agent as detected by real-time MR imaging. They also found technique allows monitoring the similar nanosized agents such therapeutic and viral vectors. A limitation procedure is unexpected leakage out targeted parenchyma or malignancies sulci ventricles. aim present study was to evaluate...
Brainstem dysfunction resulting from central extension of infection is a life‐threatening complication otitis media/interna (OMI) that has been described infrequently in dogs and cats. We review the clinical signs disease, diagnostic findings, results surgical medical treatments brainstem disease attributable to otogenic intracranial cats dogs. Eleven 4 were examined because acute, subacute, or chronic brain including vestibular signs, altered mentation, abnormal posture/gait, cranial nerve...
Summary Tumour necrosis factor (TNF)‐receptor‐associated periodic syndrome (TRAPS) is a hereditary autoinflammatory disorder involving autosomal‐dominant missense mutations in TNF receptor superfamily 1A ( TNFRSF1A ) ectodomains. To elucidate the molecular effects of TRAPS‐related mutations, we transfected HEK‐293 cells to produce lines stably expressing high levels either wild‐type (WT) or single mutant recombinant forms TNFRSF1A. Mutants with amino acid substitutions first cysteine‐rich...