A5084635352- Veterinary Orthopedics and Neurology
- Spinal Cord Injury Research
- Glioma Diagnosis and Treatment
- Veterinary Oncology Research
- Cancer Research and Treatments
- interferon and immune responses
- Virus-based gene therapy research
- Visual perception and processing mechanisms
- Spinal Fractures and Fixation Techniques
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Heterotopic Ossification and Related Conditions
- MRI in cancer diagnosis
- Pancreatic and Hepatic Oncology Research
- Spine and Intervertebral Disc Pathology
- Mechanical Circulatory Support Devices
- Head and Neck Anomalies
- Cervical and Thoracic Myelopathy
- Cardiovascular Conditions and Treatments
- Genetic and Kidney Cyst Diseases
- Chemokine receptors and signaling
- Neural and Behavioral Psychology Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Hedgehog Signaling Pathway Studies
Texas A&M University
2015-2024
Texas College
2017-2023
John Wiley & Sons (United States)
2023
Virginia–Maryland College of Veterinary Medicine
2016
Auburn University
2016
National Cancer Institute
2016
Center for Cancer Research
2016
Cornell University
2016
University of Waterloo
2006-2008
Baylor College of Medicine
2006
The updated VCOG-CTCAE v2 guidelines contain several important updates and additions since the last update (v1.1) was released in 2011 published within Veterinary Comparative Oncology 2016. As Cooperative Group (VCOG) is no longer an active entity, original authors contributors to v1.0 v1.1 were consulted for input, additional co-authors sought expansion refinement of adverse event (AE) categories. includes expanded neurology, cardiac immunologic AE sections, addition procedural-specific...
Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared molecular profiles of canine with those human pediatric adult to characterize evolutionarily conserved mammalian mutational processes gliomagenesis. Employing whole-genome, exome, transcriptome, methylation sequencing 83 gliomas, we found alterations shared such as receptor tyrosine kinases, TP53 cell-cycle pathways, IDH1 R132. Canine showed high similarity...
Neurons in primary visual cortex exhibit several nonlinearities their responses to stimuli, including response decrements repeated contrast-dependent phase advance, contrast saturation, and cross-orientation suppression. Thalamocortical synaptic depression has been implicated these phenomena but not examined directly vivo . We assessed of thalamocortical synapses using 20-100 Hz trains electrical stimuli delivered the LGN. Cortical cells receiving direct input from LGN, identified by short...
Spatial attention improves performance at attended locations and correspondingly modulates firing rates of cortical neurons. The size these behavioral neuronal effects depends on the difficulty task performed location. Psychological theorists have attributed this to a tighter focus fixed amount processing resource location, but distribution across visual field not been fully explored. We trained rhesus monkeys do detection in which spatial were manipulated independently. Probe stimuli used...
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To report recovery of ambulation dogs treated with extended thoracolumbar durotomy for severe spinal cord injury caused by intervertebral disc herniation.Descriptive cohort.Twenty-six consecutive paraplegic presented loss deep pain sensation after acute herniation.Each dog underwent routine diagnostic assessment and surgery removal extradural herniated disc, followed a four-vertebral body length centered on the disc. Each was up until it able to walk 10 steps without assistance or 6 months...
In this study, we determined the expression of key signalling pathway proteins TP53, MDM2, P21, AKT, PTEN, RB1, P16, MTOR and MAPK in canine gliomas using western blotting. Protein was defined three astrocytic glioma cell lines treated with CCNU, temozolamide or CPT-11 further evaluated 22 spontaneous including high low grade astrocytomas, oligodendrogliomas mixed oligoastrocytomas. Response to chemotherapeutic agents survival were similar that reported human lines. Alterations gliomagenesis...
The "claw sign" is a radiographic sign studied in human imaging to determine if mass arises from solid structure or organ versus close adjacent location, resulting distortion of the outline an organ. We investigated its utility characterizing MRI axial localization peripherally located intracranial glioma meningioma, due their overlap appearance. This retrospective, secondary analysis, cross-sectional study aimed report sensitivity, specificity, and inter- intraobserver variabilities using...
Abstract OBJECTIVE To estimate reliability of interpretation neurologic examination findings for localization vestibular dysfunction in dogs. DESIGN Cross-sectional study. ANIMALS 496 dogs that underwent MRI the head diagnosis a problem between September 2011 and 2015. PROCEDURES Medical records were reviewed data collected regarding signalment examination, MRI, CSF findings. Independent observers interpreted findings, agreement was assessed subset Distributions variables compared with...
Cerebral microbleeds (CMBs) are focal intraparenchymal signal voids on gradient-echo magnetic resonance imaging (MRI), corresponding to regions of chronic hemorrhage. In humans, they associated with systemic disease and shorter survival times. Although similar findings have been identified in dogs, their epidemiology clinical correlations not investigated.To determine epidemiological features, associations, associations outcome for putative CMB-like foci (putative [pMBs]) by T2*-weighted MRI...
Opioids are widely used for perioperative pain control in dogs undergoing spinal surgery, but alternatives may be required because data suggest that opioids exacerbate inflammation the injured cord and veterinary access to become more restricted future.To compare recovery of ambulation other functions between cord-injured receiving peri-operative fentanyl those a ketamine-dexmedetomidine combination.A total 102 client-owned decompressive surgery thoracolumbar intervertebral disc...
Spinal cord injury (SCI) is often accompanied by reduced bladder compliance, which contributes to adverse conditions including urinary tract infections and vesicoureteral reflux. Reduced compliance is, in part, attributed extensive remodeling of the wall, extracellular matrix (ECM). Here, we tested hypothesis that blockade metalloproteinases (MMPs), known for their ability remodel ECM, improves dogs with SCI. We first evaluated naturally occurring SCIs resulting from intervertebral disc...
Spinal cord injury (SCI) affects thousands of people each year and there are no treatments that dramatically improve clinical outcome. Canine intervertebral disc herniation is a naturally-occurring SCI has similarities to human can be used as translational model for evaluating therapeutic interventions. Here, we characterized cerebrospinal fluid (CSF) acute phase proteins (APPs) have altered expression across spectrum neurological disorders, using this canine system. The concentrations...
Early prognostic information in cases of severe spinal cord injury can aid treatment planning and stratification for clinical trials. Analysis intraparenchymal signal change on magnetic resonance imaging has been suggested to inform outcome prediction traumatic injury. We hypothesized that T2-weighted hypointensity would be associated with a lower potential functional recovery higher risk progressive neurological deterioration dogs acute, severe, naturally occurring Our objectives were to:...
Objective To evaluate outcome and adverse events following ventral stabilization of the atlantoaxial (AA) joint in dogs with clinical AA subluxation using screw/polymethymethacrylate (PMMA) constructs a retrospective, multi‐center cohort study. Study Design Historical Animals 35 client‐owned dogs. Methods Medical records from 3 institutions were reviewed to identify treated screw PMMA constructs. Data on signalment, pre‐ postoperative neurologic status, imaging performed, retrieved....
Canine intervertebral disc πherniation causes a naturally-occurring spinal cord injury (SCI) that bears critical similarities to human SCI with respect both pathomechanisms and treatment. As such, it has tremendous potential enhance our understanding of biology the preclinical evaluation novel therapies. Currently, there is limited role arachidonic acid metabolites in canine SCI. The CSF concentrations PLA2 PGE2 were higher dogs compared control (p = 0.0370 0.0273, respectively), but LCT4...
Background Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury rodents so has promise a therapy humans. There are many important differences between animals human clinical cases, making it difficult to introduce new therapies into practice. Spinal also common pet dogs requires therapies, meaning that they can act translational model for condition while deriving direct...
Abstract Background Fibrocartilaginous embolic myelopathy (FCE) is a well‐documented condition in dogs although rarely reported chondrodystrophic breeds. Genetic associations have not been defined. Objectives Define the association of chondrodystrophy‐associated FGF4L2 retrogene with histopathologically confirmed cases FCE. Animals Ninety‐eight histopathologic diagnosis Methods Retrospective multicenter study. Dogs were genotyped for and FGF4L1 retrogenes using DNA extracted from...
The objective of this prospective cohort study was to document the occurrence post-operative hypoventilation in dogs undergoing decompressive ventral slot or hemilaminectomy for treatment intervertebral disc herniation (IVDH). Twenty surgery and 20 IVDH that presented XX between 2017 2020 were enrolled. Dogs anesthetized using a standard protocol. Blood gas samples taken at up 11 time points beginning during anesthetic recovery continuing maximum 72 h post-operatively. with cervical lesions...