A5073690914- Veterinary Orthopedics and Neurology
- Spinal Cord Injury Research
- Hereditary Neurological Disorders
- Nerve injury and regeneration
- Neurological diseases and metabolism
- Spinal Dysraphism and Malformations
- Urinary Bladder and Prostate Research
- Veterinary Oncology Research
- Neurogenetic and Muscular Disorders Research
- Tissue Engineering and Regenerative Medicine
- Nerve Injury and Rehabilitation
- Mesenchymal stem cell research
- Cardiovascular Conditions and Treatments
- Veterinary Medicine and Surgery
- Human-Animal Interaction Studies
- Peripheral Neuropathies and Disorders
- Virus-based gene therapy research
- Peripheral Nerve Disorders
- Muscle Physiology and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neural Engineering
- Spine and Intervertebral Disc Pathology
- Veterinary Equine Medical Research
- Herpesvirus Infections and Treatments
- Bacterial Infections and Vaccines
University of Bristol
2013-2024
Royal Veterinary College
2017-2024
University of London
2018-2024
At Bristol
2009-2024
Universidad de Londres
2018-2021
University of Cambridge
2006-2018
Iowa State University
2016
Stem Cell Institute
2015
Laboratoire de Génétique & Evolution des Populations Végétales
2012
Queen's Hospital
2009-2011
This study was designed to determine whether an intervention proven effective in the laboratory ameliorate effects of experimental spinal cord injury could provide sufficient benefit be value clinical cases. Intraspinal olfactory ensheathing cell transplantation improves locomotor outcome after 'proof principle' experiments rodents, suggesting possibility efficacy human patients. However, animal cannot accurately model inherent heterogeneity patient cohorts, nor are all aspects their...
Abstract OBJECTIVE To investigate associations between recovery of locomotion and putative prognostic factors in dogs with loss deep pain perception the pelvic limbs caused by intervertebral disk herniation (IVDH). DESIGN Prospective cohort study. ANIMALS 78 client-owned evaluated for IVDH that underwent spinal decompression surgery. PROCEDURES Dogs complete tail routine examinations, advanced imaging, surgery accordance standards practice owner consent. For each dog, information was...
This study has tested the feasibility of using physical delivery methods, employing static and oscillating field “magnetofection” techniques, to enhance magnetic nanoparticle-mediated gene transfer rat oligodendrocyte precursor cells derived for transplantation therapies. These are a major transplant population mediate repair damage as occurs in spinal cord injury neurological diseases such multiple sclerosis. We show first time that nanoparticles effective reporter therapeutic genes...
See Moon and Bradbury (doi:10.1093/brain/awy067) for a scientific commentary on this article. Many hundreds of thousands people around the world are living with long-term consequences spinal cord injury they need effective new therapies. Laboratory research in experimental animals has identified large number potentially translatable interventions but transition to clinic is not straightforward. Further evidence efficacy more clinically-relevant lesions required gain sufficient confidence...
Three dogs were referred to The Queen's Veterinary School Hospital at University of Cambridge for chronic behavioural or locomotor disorders associated with pain. All three had been unsuccessfully treated conventional analgesics, including non-steroidal anti-inflammatory drugs, glucocorticoids and opiate agonists, prior referral, minimal no response. They investigated by neurological examination plus ancillary diagnostic tests therapeutic drug trials. Ruling out other causes pain applying...
Safe hydrogel delivery requires stiffness-matching with host tissues to avoid iatrogenic damage and reduce inflammatory reactions. Hydrogel-encapsulated cell is a promising combinatorial approach spinal cord injury therapy, but lack of in vivo clinical stiffness measurements barrier their use clinics. We demonstrate that ultrasound elastography - non-invasive, clinically established tool can be used measure intraoperatively canines spontaneous injury. In line recent experimental reports, our...
Abstract Background Traditionally, 6‐month courses of prednisolone are used to treat steroid‐responsive meningitis‐arteritis (SRMA), but this medication is associated with adverse effects that can lead poor quality life. Hypothesis/Objectives Resolution clinical signs and rate relapse SRMA would not be significantly different between a protocol 6‐week protocol. Animals Forty‐four hospital cases from multiple referral centers in the United Kingdom (2015‐2019). Twenty 44 were treated 24/44...
The optimal treatment for meningoencephalomyelitis of unknown etiology (MUE) remains unknown, despite the widespread use a variety immunosuppressive drugs.To compare efficacy prednisolone combined with either vincristine and cyclophosphamide (COP group; n= 10) or cytosine arabinoside (AraC 9).Nineteen dogs neurological deficits, neuroimaging, cerebrospinal fluid abnormalities consistent diagnosis MUE.Prospective, blinded, randomized clinical trial. Dogs fulfilling inclusion criteria were...
To report recovery of ambulation dogs treated with extended thoracolumbar durotomy for severe spinal cord injury caused by intervertebral disc herniation.Descriptive cohort.Twenty-six consecutive paraplegic presented loss deep pain sensation after acute herniation.Each dog underwent routine diagnostic assessment and surgery removal extradural herniated disc, followed a four-vertebral body length centered on the disc. Each was up until it able to walk 10 steps without assistance or 6 months...
Although many interventions for acute spinal cord injury (SCI) appear promising in experimental models, translation directly from animals to human patients is a large step that can be problematic. Acute SCI occurs frequently companion dogs and may provide model ease translation. Recently, incision of the dura has been highlighted both research as means reducing intraspinal pressure, with view improving perfusion injured tissue enhancing functional recovery. Observational clinical data humans...
Spinal epidural empyema (SEE) represents a severe pyogenic infection of the space. Clinical signs disease are non-specific – increased body temperature, intense neck pain, neurological transverse myelopathy and can lead to permanent deficits. This report describes diagnosis successful surgical treatment cervical SEE secondary grass awn migration in cat. Although it is uncommon, this should be suspected cats with progressive myelopathy. Early emergency surgery combined antibiotic therapy...
Diagnosis of feline hypertrophic cardiomyopathy currently is based on the presence myocardial hypertrophy detected using conventional echocardiography. The accuracy tissue Doppler imaging (TDI) for earlier detection disease has never been described. objective this sudy was to quantify left ventricular free wall (LVFW) velocities in cats with muscular dystrophy (HFMD) during preclinical TDI. study animals included 22 healthy controls and 7 belonging a family HFMD (2 affected adult males, 2...